Heart
Association between growth differentiation factor-15 and chronic heart failure in coronary atherosclerosis patients
Authors: Z.D. Zhu and T. Sun
We explored the association between plasma growth differentiation factor 15 (GDF-15) levels and chronic heart failure (CHF) in coronary heart disease patients. We measured plasma GDF-15 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in 269 untreated coronary heart disease patients (98 with CHF, 84 without CHF, and 87 control patients) us.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.8
- DOI:
- 10.4238/2015.March.27.8
Preliminary in vitro analysis of mechanism of cardiac microvascular endothelial barrier function
Authors: W. Dong, G.N. Zhang and S.H. Gao
To preliminarily clarify the mechanism of cardiac microvascular endothelial barrier function leading to heart failure, primary HMVEC-D cells were selected and cultured for amplification. The cells were infected with adenovirus vector containing the ADP-ribosylation factor 6 (Arf6) Q67L gene. Full-length and functional fragment.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048864
- DOI:
- 10.4238/gmr15048864
Association between �²1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis
Authors: S.T. Ma, W. Zhao,B. Liu, R.Y. Jia, C.J. Zhao and L.Q. Cui
Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.9
- DOI:
- 10.4238/2015.June.1.9
Effects of high thoracic epidural anesthesia on ischemic cardiomyopathy cardiac function and autonomic neural function
Authors: X. Wang, G.Y. Chen, S.S. Yang, Y. Tian, T. Ge2, H. Qin, W. Han and H.Y. Chang
We aimed at observing the effects of high thoracic epidural anesthesia (HTEA) on cardiac structure and function, heart rate variability (HRV), and QT interval variation (QTV) in ischemic cardiomyopathy (ICM) patients with chronic heart failure. We divided 30 ICM patients into HTEA (N = 16) and control (N = 14) groups.The contr.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.29.2
- DOI:
- 10.4238/2014.August.29.2
A de novo 2q35-q36.1 deletion incorporating IHH in a Chinese boy (47,XYY) with syndactyly, type III Waardenburg syndrome, and congenital heart disease
Authors: D. Wang, G.F. Ren, H.Z. Zhang, C.Y. Yi and Z.J. Peng
Reports of terminal and interstitial deletions of the long arm of chromosome 2 are rare in the literature. Here, we present a case report concerning a Chinese boy with a 47,XYY karyotype and a de novo deletion comprising approximately 5 Mb between 2q35 and q36.1, along with syndactyly, type III Waardenburg syndrome, and congen.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049060
- DOI:
- 10.4238/gmr15049060
Torasemide reduces dilated cardiomyopathy, complication of arrhythmia, and progression to heart failure
Authors: L.N. Han, S.L. Guo, X.M. Lin, X.M. Shi, C.B. Zang, L.M. Yang and G.L. Ding
The aim of this study was to analyze the incidence and types of arrhythmia and their relationship with the severity and prognosis of chronic heart failure (CHF) in patients with dilated cardiomyopathy (DCM), and to investigate the therapeutic effect of torasemide versus furosemide on CHF and incidence of arrhythmia. DCM patien.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.5.11
- DOI:
- 10.4238/2014.September.5.11
Single-nucleotide polymorphism of the pri-miR-34b/c gene is not associated with susceptibility to congenital heart disease in the Han Chinese population
Authors: Y.-M. Liu, Y. Wang, W. Peng, Z. Wu, X.-H. Wang, M.-L. Wang, W. Wang, J. Sun, Z.-D. Zhang and X.-M. Mo
Recent evidence has shown that the microRNA polymorphism may play an important role in the susceptibility to congenital heart disease (CHD). A potentially functional SNP rs4938723 (T>C) in the promoter region of pri-miR-34b/c might affect transcription factor GATA binding and therefore pri-miR-34b/c expression. We genotyped the pri-miR-34b/c polymorphi.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.August.12.9
- DOI:
- 10.4238/2013.August.12.9
Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy
Authors: X. Li, C.Y. Liu, Y.S. Li, J. Xu, D.G. Li, X.I. Li and D. Han
Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027465
- DOI:
- 10.4238/gmr.15027465
Identification of altered pathways in Down syndrome-associated congenital heart defects using an individualized pathway aberrance score
Authors: Y.Q. Chen, T. Li, W.Y. Guo, F.J. Su and Y.X. Zhang
The aim of this study was to identify disrupted pathways related to Down syndrome (DS), and DS-associated congenital heart defects (DS-CHD). The gene expression profile and pathway data of 10 human DS patients and 5 control samples in E-GEOD-1789 were recruited and analyzed by the individualized pathway aberrance score (iPAS) .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027601
- DOI:
- 10.4238/gmr.15027601
Identification of disturbed pathways in heart failure based on Gibbs sampling and pathway enrichment analysis
Authors: P. Chen, L.H. Guo, Y.K. Guo, Z.J. Qu, Y. Gao and H. Qiu
We identified disturbed pathways in heart failure (HF) based on Gibbs sampling combined with pathway enrichment analysis. A total of 396 Markov chains (MCs) (gene count >5) were obtained. After Gibbs sampling, six differentially expressed molecular functions (DEMFs) (possibility ≥0.8) were obtained. As statistical analys.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027956
- DOI:
- 10.4238/gmr.15027956