Hemoglobinopathies
Characterization of molecular hemoglobin c and beta thalassemia
Authors: M.H. Lagares, M.S. Rabelo, C.G.B. Dias-penna, R.S. Mascarenhas, K.S.F. Silva and K.K.V.O. Moura
The hemoglobinopathies are a group of hereditary alterations prevalent in many parts of the world, but significantly affect the Brazilian population for its abundant miscegenation. These alterations in structural genes that cause the formation of hemoglobin variants, and/or regulatory genes, causing thalassemias. Currently, th.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039851
- DOI:
- 10.4238/gmr16039851
Three-dimensional visualization of human hemoglobin phenotypes with HPLC
Authors: L.M. Storti-Melo P.H. Mangonaro C.R. Val�?ªncio C. Traina Junior C.R.B. Domingos
Hemoglobinopathies were included in the Brazilian Neonatal Screening Program on June 6, 2001. Automated high-performance liquid chromatography (HPLC) was indicated as one of the diagnostic methods. The amount of information generated by these systems is immense, and the behavior of groups cannot always be observed in individua.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr530
- DOI:
- 10.4238/vol8-1gmr530
Contribution to the study of molecular defects of hemoglobin in the Brazilian population
Authors: Paula Juliana Antoniazzo Zamaro
The hemoglobinopathies belong to a diverse group of inherited disorders characterized by the reduced synthesis of one or more globin chains (thalassemia) or the synthesis of a structurally abnormal hemoglobin (Hb). Approximately 900 different hemoglobin variants characterized by mutations involving alpha, beta, gamma, and delta globin chains have been des.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1ta012
- DOI:
- 10.4238/vol7-1ta012
Abnormal hemoglobin phenotypes in carriers of mild anemia in Latin America
Authors: P.J.A. Zamaro and C.R. Bonini-Domingos
We looked for abnormal hemoglobins in blood samples sent for diagnosis of anemia. Identification of the hemoglobins was made using electrophoretic, chromatographic and molecular procedures. The 2020 blood samples were of patients from various regions of Brazil and from some other Latin American countries. Among the abnormal he.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr721
- DOI:
- 10.4238/vol9-1gmr721