Inflammation
Intestinal Dysbiosis Increases the Incidence of Malignant Melanoma in Mice Model
Authors: Xiaomeng Ren, Xin Zhang, Yanyan Zhu, Yaser Gamallat, Abdo Meyiah, Shenhao Ma, Yi Xin
Antibiotic-induced disruption of the intestinal microbiota has serious consequences for human physiology. We conducted a microbial dysbiosis animal model to study and directly provide evidence for microbial dysbiosis contribution to malignant melanoma animal model. Females C57BL/6 wild-type (WT) mice injected with a limiting t.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039840
- DOI:
- 10.4238/gmr16039840
Genetic polymorphisms of paraoxonase1 192 and glutathione peroxidase1 197 enzymes in familial Mediterranean fever
Authors: F. ��ktem, H. An�±l, R. S�¼tc�¼ and A.E. Kuybulu
Familial Mediterranean fever (FMF) is an autosomal recessive disorder and is the most frequent of the periodic febrile inflammatory syndromes. The pathogenesis of the disease is not completely understood, even though the FMF gene has been identified. Oxidative stress and inflammation may play a role in the pathogenesis of FMF... Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.29.7
- DOI:
- 10.4238/2014.April.29.7
Transient increase in IL-1�², IL-6 and TNF-�± gene expression in rat liver exposed to gold nanoparticles
Authors: H.A. Khan, M.A.K. Abdelhalim, A.S. Alhomida, M.S. Al Ayed
Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.12
- DOI:
- 10.4238/2013.November.22.12
Effects of genetic variants of CCR5 chemokine receptors on oral squamous cell carcinoma
Authors: C.R. Tanyel1, Z.B. Cincin2, B. Gokcen-Rohlig1, K. Bektas-Kayhan3, M. Unur3 and B. Cakmakoglu2
We aimed to evaluate the effect of genetic variants of the chemokine C-C motif receptor (CCR5) in the pathogenesis of oral squamous cell carcinoma (OSCC). A total of 127 patients diagnosed with OSCC and 104 healthy individuals were included in the study. The polymorphisms CCR5 59029 and CCR5-delta32 were assessed with the polymerase chain reaction-restric.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.20
- DOI:
- 10.4238/2013.November.18.20
RXR agonists inhibit high glucose-induced upregulation of inflammation by suppressing activation of the NADPH oxidase-nuclear factor-�ºB pathway in human endothelial cells
Authors: R.B. Ning, J. Zhu, D.J. Chai, C.S. Xu, H. Xie, X.Y. Lin, J.Z. Zeng and J.X. Lin
An inflammatory response induced by high glucose is a cause of endothelial dysfunction in diabetes and is an important contributing link to atherosclerosis. Diabetes is an independent risk factor of atherosclerosis and activation of retinoid X receptor (RXR) has been shown to exert anti-atherogenic effects. In the present study, we examined the effects of.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.13.3
- DOI:
- 10.4238/2013.December.13.3
Acanthopanax senticosus attenuates inflammation in lipopolysaccharide-induced acute lung injury by inhibiting the NF-�ºB pathway
Authors: X.J. Fei, L.L. Zhu, L.M. Xia, W.B. Peng and Q. Wang
The dried roots of the plant Acanthopanax senticosus (AS) are used in traditional Oriental medicine and reportedly possess anti-inflammatory properties in vitro. However, whether AS has the same anti-inflammatory effect in vivo and the underlying mechanisms of this action remain unknown. In this study, we pretreated a mouse model of lipopolysaccharide-ind.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.16
- DOI:
- 10.4238/2014.December.12.16
Protective effect of lyophilized recombinant human brain natriuretic peptide on renal ischemia/reperfusion injury in mice
Authors: X. Cao, H.Y. Xia, T. Zhang, L.C. Qi, B.Y. Zhang, R. Cui, X. Chen, Y.R. Zhao and X.Q. Li
Brain natriuretic peptide (BNP) has a protective effect on acute injury of the heart, brain, and lung. However, its role in acute kidney injury (AKI) remains unclear. The aim of this study was to investigate the effect of lyophilized recombinant human BNP (lrh-BNP) on AKI and the underlying molecular mechanisms. An experimental model for AKI was establish.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.26
- DOI:
- 10.4238/2015.October.26.26
MicroRNA-139 modulates Alzheimer�s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2
Authors: Y. Tang, J.S. Bao, J.H. Su and W. Huang
Alzheimer’s disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as we.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019166
- DOI:
- 10.4238/gmr16019166
Immunomodulatory and neuroprotective effect of cryopreserved allogeneic mesenchymal stem cells on spinal cord injury in rats
Authors: I.R. Rosado, P.H. Carvalho, E.G.L. Alves, T.M. Tagushi, J.L. Carvalho, J.F. Silva, M.S.L. Lavor, K.M. Oliveira, R. Serakides, A.M. Goes, E.G. Melo
This study aimed to evaluate the immunomodulatory and neuroprotective effects of allogeneic and cryopreserved mesenchymal stem cells (MSCs) on spinal cord injury. A total of 120 rats were distributed into the following groups: negative control (NC) - without injury, positive control (PC) - with injury without treatment, and group treated with MSC (GMSC) - wi.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019555
- DOI:
- 10.4238/gmr16019555
Activation of p38-mitogen-activated protein kinase contributes to ischemia reperfusion in rat brain
Authors: Y.Q. Song, H.L. Zou, Y.J. Zhao, L.Q. Yu, Z.X. Tan and R. Kong
Inflammation plays an important role in cerebral ischemia reperfusion, which can cause severe damage to the brain and may lead to cerebral hemorrhage transformation. p38-mitogen-activated protein kinase (p38mapk) has been implicated in the etiology of a number of diseases because it is a cause of inflammation, but comparatively little research has been ca.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038492
- DOI:
- 10.4238/gmr.15038492