Inflammation
Correlation between adiponectin and hemorrhagic shock in mice
Authors: X. Gong, Y. Liu, S. Yao, J.F. Zheng, F. Wan, X.D. Xiang and X.P. Chai
The aim of this study was to explore the relationship between adiponectin (ADPN) and hemorrhagic shock (HS) and the recovery after HS. This is significant for further understanding of the pathophysiological processes of HS and the development of better treatments. In total, 72 male C57BL/6 mice were assigned randomly to three groups: control, HS, and reco.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017037
- DOI:
- 10.4238/gmr.15017037
Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts
Authors: P.K. Mishra A. Bhargava G.V. Raghuram S. Gupta S. Tiwari R. Upadhyaya S.K. Jain K.K. Maudar
Lungs comprise the primary organ exposed to environmental toxic chemicals, resulting in diverse respiratory ailments and other disorders, including carcinogenesis. Carcinogenesis is a multi-stage phenomenon, which involves a series of genetic alterations that begin with genomic instability provoked by certain factors such as i.. Read More»
- Genet. Mol. Res. 8(1):
- vol8-1gmr544
- DOI:
- 10.4238/vol8-1gmr544
Evaluation of glutathione peroxidase and superoxide dismutase enzyme polymorphisms in celiac disease patients
Authors: M. Katar, A.F. Ozugurlu, H. Ozyurt and I. Benli
Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present s.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.20.4
- DOI:
- http://dx.doi.org/10.4238/2014.February.20.4
Efficacy of oral administration of lactic acid bacteria isolated from cocoa in a fermented milk preparation: reduction of colitis in an experimental rat model
Authors: T.F. dos Santos, T.A. Melo, D.S. Santos, R.P. Rezende, J.C.T. Dias and C.C. Romano
We investigated the probiotic potential of lactic acid bacteria (LAB) obtained from cocoa fermentation using an experimental rat model of colitis. Cocoa beans were collected from fermentation boxes every 12 h for 5 days to isolate the microorganisms. Strains were isolated by serial dilution and plating on MRS agar. Gram-positive and catalase-negative rods.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038097
- DOI:
- 10.4238/gmr.15038097
Quantitation of glucocorticoid receptor alpha and NF-�ºB pathway mRNA and its correlation with disease activity in rheumatoid arthritis patients
Authors: L.O. Cavalcante, M.R. Melo, V.G. Dinis, R.B. Castro, B.D.B. Souza and C.A. Longui
We measured NF-κB, IKK, c-Fos, and GRα mRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients .. Read More»
- Genet. Mol. Res. 9(4):
- vol9-4gmr970
- DOI:
- 10.4238/vol9-4gmr970
+294T/C polymorphism in the PPAR-�´ gene is associated with risk of coronary artery disease in normolipidemic Tunisians
Authors: I. Jguirim-Souissi, A. Jelassi, Y. Hrira, M. Najah, A. Slimani, F. Addad, M. Hassine, K.B. Hamda, F. Maatouk, M. Rouis and M.N. Slimane
Peroxisome proliferator-activated receptor delta (PPAR-δ) is a transcription factor implicated in metabolism and inflammation. The +294T/C polymorphism in the PPAR-δ gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men. Whether this polymorphism influences.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr831
- DOI:
- 10.4238/vol9-3gmr831
Puerarin prevents inflammation and apoptosis in the neurocytes of a murine Parkinson�s disease model
Authors: M. Jiang, Q. Yun, G. Niu, Y. Gao, F. Shi and S. Yu
The aim of this study was to investigate Parkinson’s disease (PD) using a murine model of PD. Specifically, we aimed to explore the mechanism by which puerarin prevents inflammation and apoptosis in neurocytes. Eighty healthy male C57/BL6 mice were randomly selected and divided into four groups (N = 20 each): control gro.. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15047501
- DOI:
- 10.4238/gmr.15047501
TNFR1 -383 AÃ?Â?C polymorphism and ankylosing spondylitis in a Russian Caucasian population: a preliminary study
Authors: V. Mordovskii, A. Semenchukov, S.Y. Nikulina, A.B. Salmina, A. Chernova, E. Kapustina, A. Kents, A. Ohapkina, E. Moskaleva, P.E. Maltese, P. Convertini, M. Bertelli
The aim of this study was to assess the association between the TNFR1 rs2234649 polymorphism and ankylosing spondylitis susceptibility in a Russian Caucasian population. A total of 41 ankylosing spondylitis patients and 43 healthy controls, matched according to age and sex, were enrolled, and polymerase chain reac.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019581
- DOI:
- 10.4238/gmr16019581
Protective effect and mechanism of probucol in the treatment of spinal cord injury
Authors: W.B. Zhu, Y.H. Wang, G.F. Sun and J.H. Wu
To investigate the effects of probucol on the treatment of spinal cord injury in rat, 80 rats were randomly divided into two groups of 40: a group treated with probucol and a control group. Allen’s method was used to establish a rat model of spinal cord injury. After establishment, probucol (500 mg·kg-1·day-1) was intraperitoneally inj.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.11
- DOI:
- 10.4238/2015.July.17.11
Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases
Authors: Z.-Z. Liang, J. Li, S.-G. Huang
The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019329
- DOI:
- 10.4238/gmr16019329