Inflammation
Analysis of key genes and pathways involved in acute lung injury in a mouse model
Authors: Q.H. Han, N. Han, Y.Z. Liu, Q.H. Jin, Q.Y. Lu and Z.C. Li
A mouse model of acute lung injury (ALI) was chosen in this study to explore the key genes and pathways involved in the process of ALI with microarray technology. Gene expression microarray data were downloaded from the Gene Expression Omnibus database. Mice from the experimental group were further divided into 6 subgroups, wh.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.18.1
- DOI:
- http://dx.doi.org/10.4238/2014.June.18.1
Single nucleotide polymorphisms in the CXCR1 gene and its association with clinical mastitis incidence in Polish Holstein-Friesian cows
Authors: J. Pokorska, M. Dusza, D. Ku��aj, K. �»ukowski and J. Makulska
The aim of this study was to identify the association between single nucleotide polymorphisms (SNPs) in the bovine chemokine receptor (CXCR1) gene and the resistance or susceptibility of cows to mastitis. The analysis of the CXCR1 polymorphism was carried out using polymerase chain reaction restriction fragment length polymorp.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027247
- DOI:
- 10.4238/gmr.15027247
Serum YKL-40 levels are associated with type 2 diabetes mellitus in patients with obstructive sleep apnea syndrome
Authors: L. Sun, J.Y. Liu and L.R. Li
Patients with obstructive sleep apnea syndrome (OSAS) have an increased risk for type 2 diabetes mellitus (T2DM). It has been recently demonstrated that serum YKL-40 levels, also named as human cartilage glycoprotein 39, are elevated in T2DM patients. The aim of this study was to determine whether serum YKL-40 levels are associated with T2DM in patients w.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.15
- DOI:
- 10.4238/2015.August.3.15
Effects of Danhong injection on hemodynamics and the inflammation-related NF-�ºB signaling pathway in patients with acute cerebral infarction
Authors: Y. Jiang and Y.J. Lian
The objective of the current study was to investigate effects of Danhong injection on hemodynamics, inflammatory cytokines, and the NF-κB pathway in acute cerebral infarction. In total, 246 patients with acute cerebral infarction were divided into control (N = 121) and observation (N = 125) groups based on treatment. The control group underwent conv.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.21
- DOI:
- 10.4238/2015.December.14.21
Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults
Authors: R. Hannum, F.R. Godoy , A.S. da Cruz, T.C. Vieira, L.B. Minasi, D. de M. e Silva, C.C. da Silva and A.D. da Cruz
Because of the complex interaction between periodontal pathogens and the host defense system, periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue damage. Genetic mechanisms may interfere with the gene expression of important inflammation mediators, modulating the immunologic response of an individu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.7
- DOI:
- 10.4238/2015.December.22.7
Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-�ºB pathway
Authors: M. Zhang, J.M. Lin, X.S. Li, J. Li
Quercetin, a dietary flavonoid abundant in fruits, vegetables, and herbs, presents various pharmacological effects. This study aimed to investigate the anti-inflammatory effect and the underlying mechanism of quercetin in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs). Cell viability was m.. Read More»
- Genet. Mol. Res. 15(2):