Invasion
Regulatory role of microRNA184 in osteosarcoma cells
Authors: G.R. Yin1,2, Q. Wang3, X.B. Zhang2 and S.J. Wang1
Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expresse.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.8
- DOI:
- 10.4238/2015.November.13.8
Inhibition of invasion and migration of prostate cancer cells by miRNA-509-5p via targeting MDM2
Authors: X.M. Tian, Y.Z. Luo, P. He, J. Li, Z.W. Ma and Y. An
Prostate cancer is a common malignancy of the male reproductive-urinary system. MDM2 is an oncogene, whose expression can be regulated by microRNA (miRNA). The present study investigated the expression and correlation of miRNA-509-5p and MDM2 to determine the mechanism of their function in invasion and migration of prostate ca.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019195
- DOI:
- 10.4238/gmr16019195
Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells
Authors: L. Zhang, H.E.X.D. Niyazi, H.R. Zhao, X.P. Cao, M.N.S. Abudula, W.J. Ye, S.A. Zhang, R.H.M. Yiming, Y. Zhang, W.P. Su, R. Chen, Y. Ouyang, N. Miao and Y.X. Bao
Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyze.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019269
- DOI:
- 10.4238/gmr16019269
Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target
Authors: H.-B. Zhao, X.-F. Zhang, H.-B. Wang and M.-Z. Zhang
Migration and invasion enhancer 1 (MIEN1) is a membrane-anchored protein that is highly expressed in various types of cancer, and is correlated with the PI3K/AKT pathway. The aim of this study was to investigate the expression of MIEN1 and its clinical pathological significance in breast cancer. We used immunohistochemical sta.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019380
- DOI:
- 10.4238/gmr16019380
Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion
Authors: T.Y. Liu1, H. Zhang2, S.M. Du3, J. Li1 and X.H. Wen1
This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control grou.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017746
- DOI:
- 10.4238/gmr.15017746
Influence of suppression of CapG gene expression by siRNA on the growth and metastasis of human prostate cancer cells
Authors: B.K. Li, K. Guo, C.Y. Li, H.L. Li, P.P. Zhao,K. Chen,C.X. Liu
This study investigated CapG gene expression in prostate cancer cell lines; in addition, we explored the effects of CapG suppression on DU145 cell growth, and the underlying mechanism with which CapG affects DU145 cell growth and invasiveness. The expression of CapG and 18 related genes in DU145 cells was analyzed by flow cyto.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.28
- DOI:
- 10.4238/2015.December.1.28
In vitro inhibition of invasion and metastasis in colon cancer cells by TanIIA
Authors: R.W. Zhang, Z.G. Liu, Y. Xie, L.X. Wang, M.C. Li and X. Sun
The purpose of this study was to investigate the effect of the traditional Chinese medicine TanIIA on the viability, invasion, and metastasis of SW480 cells. SW480 cells were treated with TanIIA for 24 h, and MTT assays were performed to determine the effect of TanIIA on cell viability. Transwell transmembrane experiments were applied to test the effect o.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039008
- DOI:
- 10.4238/gmr.15039008
MicroRNA-215 functions as a tumor suppressor and directly targets ZEB2 in human pancreatic cancer
Authors: Q.W. Li,T. Zhou, F. Wang,M. Jiang, C.B. Liu, K.R. Zhang, Q. Zhou, Z. Tian, K.W. Hu
It has been shown that microRNA-215 (miR-215) is dysregulated in several human malignancies, and this correlates with tumor progression. However, its expression and function in pancreatic cancer is still unclear. The aim of this study was to explore the effects of miR-215 on pancreatic cancer formation and progression. Using q.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.2
- DOI:
- 10.4238/2015.December.8.2
Effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma A375 cells
Authors: Y.P. Zhang, Y.Q. Li, Y.T. Lv and J.M. Wang
Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentratio.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.9
- DOI:
- 10.4238/2015.February.6.9
Expression of PAPPA2 in human fetomaternal interface and involvement in trophoblast invasion and migration
Authors: H.Y. Wang, Z. Zhang and S. Yu
Pregnancy-associated plasma protein-A 2 (PAPPA2) is a placental-enriched gene that is important for normal human placentation and defects in the gene can cause complications in pregnancy. Yet the exact expression pattern and role of PAPPA2 in the human fetomaternal interface are not clear. In this study, in situ hybridization (ISH) and immunohistochemistr.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038075
- DOI:
- 10.4238/gmr.15038075