Invasion
Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and T.L. Dong
Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.28
- DOI:
- 10.4238/2015.July.3.28
Clinical significance of lymphatic vessel invasion in stage I non-small cell lung cancer patients
Authors: K.F. Ma, X.Y. Chu and Y. Liu
The aim of this retrospective study was to evaluate the prognostic influence of lymphatic vessel invasion (LVI) in stage I non-small cell lung cancer (NSCLC) patients. From January 2004 to December 2007, LVI was detected in 57 patients with T1N0M0 NSCLC; therefore, 114 patients with the same pathology, T stage, and surgery method, but without LVI, were se.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.13.10
- DOI:
- 10.4238/2015.March.13.10
Hypoxia-inducible factor-2�± (HIF-2�±) mediates the effects of hypoxia on the promotion of HeLa cell viability, colony formation, and invasion capacity in vitro
Authors: J. Xiong, F.F. Zhu and M.F. Nie
Hypoxia reduces the oxygen supply to tumor cells and may limit tumor cell growth. However, hypoxia promotes tumor cell metabolic adaptation, apoptosis resistance, angiogenesis, invasion, and metastasis. Hypoxia-inducible factor-2a (HIF-2a) may be responsible for these hypoxia-induced changes. In this study, we investigated the effects of hypoxia and HIF-2.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.7
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.7
Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression
Authors: Z.T. Wang, H.Y. Gong, F. Zheng, D.J. Liu and X.Q. Yue
Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasionwere detected by MTT assay, flow c.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.20
- DOI:
- 10.4238/2015.July.17.20
Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells
Authors: C. Zhao, Z.G. Ma, S.L. Mou, Y.X. Yang, Y.H. Zhang, W.C. Yao
MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019281
- DOI:
- 10.4238/gmr16019281
From unicellularity to multicellularity - molecular speculations about early animal evolution
Authors: H.F. Hoenigsberg, M.H. TÃ?Âjaro and C. Sanabria
A morphological, physiological, developmental, and genetic organization of great complexity ineluctably unfolded from relatively simple phenomena invested with enormous potential. Sometime long ago in the Protererozoic times, parasitic invasions caused lower evolutionary levels to integrate into higher-level selection. Therefore, we have a multi-level sel.. Read More»
- Genet. Mol. Res. 7(1):
- vol7-1gmr375
- DOI:
- 10.4238/vol7-1gmr375
Communal use of integumental wounds in honey bee (Apis mellifera) pupae multiply infested by the ectoparasitic mite Varroa destructor
Authors: Ghazwan Kanbar and Wolf Engels
The ectoparasitic bee mite, Varroa destructor, is highly adapted to its natural and adopted honey bee hosts, Apis cerana and Apis mellifera. Adult females perforate the integument of bee pupae in such a way that they and their progeny can feed. We examined the wounds that founder females made, and usually found one, and rarely.. Read More»
- Genet. Mol. Res. 4(3):
Downregulation of microRNA-630 inhibits cell proliferation and invasion and enhances chemosensitivity in human ovarian carcinoma
Authors: Y.T. Zou, J.Y. Gao, H.L. Wang, Y. Wang, H. Wang and P.L. Li
MicroRNAs (miRNAs) are a family of small non-coding RNAs (approximately 21-23 nt long) that can target genes for either degradation of mRNA or inhibition of translation. miRNAs have not been comprehensively studied in human epithelial ovarian carcinoma (EOC). MicroRNA-630 (miR-630) has been frequently observed to be aberrantly expressed in various types o.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.25
- DOI:
- 10.4238/2015.July.31.25
Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis
Authors: Y.L. Wang, W.G. Gong and Q.L. Yuan
Thyroid cancer is the most common type of endocrine tumor. MicroRNAs (miRNAs) play a critical role in a variety of diseases, especially cancer occurrence and progression. However, the specific mechanism by which miRNAs trigger disease states has not been fully elucidated. This study aims to investigate the role of miR-27a in t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049070
- DOI:
- 10.4238/gmr15049070
Delimiting invasive Myriophyllum aquaticum in Kashmir Himalaya using a molecular phylogenetic approach
Authors: M.A. Shah, M.A. Ali, F.M. Al-Hemaid and Z.A. Reshi
Myriophyllum aquaticum (Vell.) Verdc. (family Haloragaceae) is one of the most invasive and destructive South American aquatic plant species and is present in a wide range of geographic regions, including the Kashmir Himalaya. Confusion regarding the taxonomic delimitation of M. aquaticum in the Himalayan region impedes effective and tar.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.233539
- DOI:
- 10.4238/2014.September.12.233539