Invasion
miR-133 inhibits pituitary tumor cell migration and invasion via down-regulating FOXC1 expression
Authors: D.S. Wang, H.Q. Zhang, B. Zhang, Z.B. Yuan, Z.K. Yu, T. Yang, S.Q. Zhang, Y. Liu and X.X. Jia
Many studies have shown that microRNA (miR)-133 functions as a tumor suppressor in a variety of metastatic cancers, including breast cancer, gastric cancer, and liver fibrosis. However, the influence of miR-133 on pituitary tumor malignancy has not yet been reported. The purpose of this study was to explore the role of miR-133.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017453
- DOI:
- 10.4238/gmr.15017453
Increased expression of the lncRNA BANCR and its prognostic significance in human osteosarcoma
Authors: Z.Q. Peng, R.B. Lu, D.M. Xiao and Z.M. Xiao
Long noncoding RNAs (lncRNAs) play important roles in the formation and progression of many types of human malignancies. The aim of our study was to investigate the expression and biological functions of the lncRNA BRAF-activated noncoding RNA (BANCR) in human osteosarcoma. BANCR expression was quantified by real-time PCR in h.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017480
- DOI:
- 10.4238/gmr.15017480
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
Authors: X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017318
- DOI:
- 10.4238/gmr.15017318
MicroRNA-181b expression in prostate cancer tissues and its influence on the biological behavior of the prostate cancer cell line PC-3
Authors: L. He, H. Yao, L.H. Fan, L. Liu, S. Qiu, X. Li, J.P. Gao and C.Q. Hao
We examined microRNA-181b (miRNA) expression in prostate cancer tissues and its effect on the prostate cancer cell line PC-3. Tissues from 27 cases of prostate cancer and 30 samples of normal human prostate were collected by surgical removal. Total miRNA was extracted, and the relative expression of miR-181b was quantified using RT-PCR. miR-181b ASO was t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.17
- DOI:
- 10.4238/2013.April.2.17
MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma
Authors: Y.B. Ma, D.W. Song, R.H. Nie and G.Y. Mu
MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uvea.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027935
- DOI:
- 10.4238/gmr.15027935
Decreased miR-452 expression in human colorectal cancer and its tumor suppressive function
Authors: T. Tang, G.C. Zhang, C.F. Li, Y.F. Liu and W.Y. Wang
-.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027730
- DOI:
- 10.4238/gmr.15027730
Regulating effect of MMP-9 and TIMP-1 in pituitary adenoma invasion
Authors: J.H. Mao, H. Guo, N. Si, L. Qiu, L.F. Guo, Z.S. Sun, Y. Xiang, X.H. Yang, W.G. Zhao and W.C. Zhang
Pituitary adenomas can cause endocrine disorder and organ damage, with some aggressive ones leading to a high postoperative recurrence rate. The occurrence and development of these type of tumors is closely related with matrix metalloproteinases (MMPs) and endogenous specific tissue inhibitor of MMPs (TIMPs). In this study, the relationship between pituit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.9
- DOI:
- 10.4238/2015.December.16.9
Metastasis-associated gene 1 expression in human medulloblastoma and its association with invasion and metastasis in medulloblastoma Daoy cell lines
Authors: Y.S. Chen, S.P. Li, H. Xiao, Z.Y. Xie, M.X. Tan, B. Liu and W.M. Zhang
This study aims to investigate the expression of metastasis-associated gene 1 (MTA1) in human medulloblastoma, and its significance in the invasion and metastasis in a medulloblastoma cell line. Positive expression rate of MTA1 protein in medulloblastoma and adjacent normal tissues collected from 29 medulloblastoma patients was detected by immunohistochem.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027894
- DOI:
- 10.4238/gmr.15027894
Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma
Authors: L.Q. Zhang, S.L. Sun, W.Y. Li , Z. Feng, X.Y. Xu, Q.S. Zhuang and J. Fang
Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.19
- DOI:
- 10.4238/2015.December.23.19