Kidney Disease
MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection
Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro
Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has man.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039933
- DOI:
- http://dx.doi.org/10.4238/gmr16039933
Pulmonary hypertension in patients with stage 1-3 chronic kidney disease
Authors: Q.M. Yang and X.R. Bao
Pulmonary hypertension (PH) secondary to chronic kidney disease (CKD) is common, but in stages 1-3 CKD patients, it remains unclear. We sought to evaluate the prevalence of PH and elucidate the possible pathogenesis in Chinese patients with early stage kidney disease. Doppler-estimated pulmonary systolic artery pressure (PASP).. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.25
- DOI:
- 10.4238/2014.July.25.25
eNOS gene Glu298Asp and 4b/a polymorphisms are associated with renal function parameters in Mexican patients with Fabry disease
Authors: A. Marin-Medina, A.J.L. Brambila-Tapia, V.J. Picos-C�¡rdenas, M.P. Gallegos-Arreola and L.E. Figuera
Fabry disease (FD) is an inherited X-linked lysosomal disease that causes renal failure in a high percentage of affected individuals. The eNOS gene encodes for endothelial nitric oxide synthase, which plays an important role in glomerular hemodynamics. This gene has two main polymorphisms (Glu298Asp and 4b/a) that have been st.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15047802
- DOI:
- 10.4238/gmr15047802
Proteomic analysis revealed the altered kidney protein profile of a Cyld knockout mouse model
Authors: Y. Zhao, Y. Zhang, H.B. Song, F. Wu, X.L. Wang, S.-C. Sun, T.X. Cui and D.Q. Tang
The aim of this study was to compare the proteomics pattern of the kidneys from Cyld knockout mice with that from normal mouse kidneys and establish a preliminary understanding of the role of Cyld in the kidney. Proteins from the kidneys of knockout Cyld mice and wild-type mice were extracted, isobaric tags for relative and absolute quantitation (iTRAQ) w.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.14
- DOI:
- 10.4238/2015.June.1.14
Whole-exome analysis of a child with polycystic kidney disease and ventriculomegaly
Authors: M.M. Nabhan,H. Abdelaziz,Y. Xu,R. El Sayed,M. Santibanez-Koref,N.A. Soliman and J.A. Sayer
Autosomal recessive polycystic kidney disease (ARPKD) is an inherited ciliopathy leading to progressive kidney and liver disease. Biallelic mutations in the PKHD1 gene underlie this condition. We describe a child with bilaterally enlarged cystic kidneys, portal hypertension, and cerebral ventriculomegaly. Molecular genetic investigations using whole-exome.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.11
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.11