Lung Cancer
XRCC1 rs25487 polymorphism is associated with lung cancer risk in epidemiologically susceptible Chinese people
Authors: X. Wang, K.W. Ma, Y.G. Zhao, G.J. Wang, W. Li
Base excision repair (BER) plays an important role in maintaining genome integrity and anti-cancer drug resistance. Single nucleotide polymorphisms (SNPs) in BER genes were detected in 500 lung cancer patients and 500 cancer-free controls. A logistic regression model was applied to analyze the relationship between lung ca.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.3
- DOI:
- 10.4238/2015.December.1.3
Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis
Authors: Y. Liu, X.L. Song, G.L. Zhang, A.M. Peng, P.F. Fu, P. Li, M. Tan, X. Li, M. Li and C.H. Wang
The objective of the current study was to assess the utility of 64-row helical computed tomography angiography (CTA) in the evaluation of extremity vascular traumas. The extremities from 17 clinical cases of suspected traumatic vascular damage were evaluated using 64-row helical CTA. To evaluate extremity vascular traumas using CTA, volume rendering, mult.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.15.19
- DOI:
- 10.4238/2015.January.15.19
Combined detection of p53, p16, Rb, and EGFR mutations in lung cancer by suspension microarray
Authors: Y. Ye, D. Wang, C. Su, T. Rong and A. Guo
Mutations of some contributing factors (p53, p16, Rb, and EGFR) are believed to affect diagnosis and drug resistance of lung cancer. We evaluated the efficacy of a multimarker panel for molecular diagnosis of lung cancer, using a high-throughput suspension microarray. One hundred and twenty-five lung cancer specimens and 30 tu.. Read More»
- Genet. Mol. Res. 8(4):
- vol8-4gmr627
- DOI:
- 10.4238/vol8-4gmr627
Detecting circulating tumor cells in patients with advanced non-small cell lung cancer
Authors: Y.H. Xu, J. Zhou and X.F. Pan
We explored the expression and clinical significance of circulating tumor cells (CTCs) in patients with advanced non-small cell lung cancer (NSCLC). Sixty-six patients with advanced NSCLC at the Oncology Department of Jinzhou Hospital were selected as an observation group between February and December 2013. Healthy volunteers and 20 benign lung disease pa.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.1.1
- DOI:
- http://dx.doi.org/10.4238/2015.September.1.1
XPG polymorphisms are associated with prognosis of advanced non-small cell lung cancer treated with platinum-based doublet chemotherapy
Authors: H.Z. Zou and Y.Q. Zhao
We conducted a cohort study to investigate whether 3 potential single nucleotide polymorphisms (SNPs) in the xeroderma pigmentosum complementation group G (XPG) gene could predict the survival of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based doublet chemotherapy. We enrolled 262 patients with histologically confirmed NSC.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.3
- DOI:
- 10.4238/2015.January.26.3
Identifying differentially expressed genes and pathways in two types of non-small cell lung cancer: adenocarcinoma and squamous cell carcinoma
Authors: J. Liu, X.Y. Yang and W.J. Shi
Non-small cell lung carcinoma, NSCLC, accounts for 80-85% of lung cancers. NSCLC can be mainly divided into two types: adenocarcinoma (ADC) and squamous cell carcinoma (SCC). The purpose of our study was to identify and differentiate the pathogenesis of ADC and SCC at the molecular level. The gene expression profiles of ADC an.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.8.8
- DOI:
- 10.4238/2014.January.8.8
Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy
Authors: Zhang, W. Ma, Y. Li, J. Wu and G.Y. Shi
Individual differences in chemosensitivity and clinical outcome of non-small-cell lung carcinoma (NSCLC) patients can be influenced by host-inherited factors. We investigated the impact of XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln, XPD Arg156Arg, XPD Asp312Asn, XPD Asp711Asp, and XPD Lys751Gln gene polymorphisms on tre.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.14.2
- DOI:
- 10.4238/2014.January.14.2
Meta-analysis of the relationship between p21 Ser31Arg polymorphism and lung cancer susceptibility
Authors: G. Lin, F. Fang, X.-J. Yu and L. Yu
The cyclin-dependent kinase inhibitor 1A (also known as p21) is thought to be involved in tumor development by mediating cell cycle arrest through the inhibition of cyclin/CDK activity. To explore the relationship of Ser31Arg polymorphism in the p21 gene with the risk of developing lung cancer, we performed an overall and stra.. Read More»
- Genet. Mol. Res. 10(4):
- 2011.October.13.2
- DOI:
- 10.4238/2011.October.13.2
Role of VEGF gene polymorphisms in the clinical outcome of non-small cell lung cancer
Authors: N. Chen, C.N. Ma, M. Zhao, Y.J. Zhang
This report details a study conducted to assess the role of VEGF gene polymorphisms in the prognosis of advanced non-small cell lung carcinoma (NSCLC). Samples obtained from 210 advanced NSCLC patients admitted at the Huaihe Hospital of Henan University between January 2010 and December 2011 were recruited for this study. The .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.13
- DOI:
- 10.4238/2015.December.7.13
Genetic variations in the IGF-IGFR-IGFBP axis confer susceptibility to lung and esophageal cancer
Authors: X.P. Huang, W.H. Zhou and Y.F. Zhang
Recent evidence suggests that genetic variations in the insulin-like growth factor (IGF)-IGF receptor (IGFR)-IGF binding proteins (IGFBP) axis may impact an individual’s susceptibility to lung and esophageal cancer, but individually published results are inconclusive. Our meta-analysis aimed at providing a more precise e.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.24.17
- DOI:
- 10.4238/2014.January.24.17