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Lung Cancer

Human Genetics   Research Article

Erlotinib enhances the CIK cell-killing sensitivity of lung adenocarcinoma A549 cells

Authors: J.Z. Mei, G.J. Liu, X.J. Zhang, J.Z. Zhao and R.T. Feng

We examined the effects and molecular mechanism of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib on NKG2D ligand expression in human lung adenocarcinoma A549 cells and the cytotoxicity of cytokine-induced killer cells. Flow cytometry was used to detect NKG2D ligand expression in A549 cells under effects of erlotinib and E.. Read More»

Genet. Mol. Res. 14(2):
http://dx.doi.org/2015.April.10.18
DOI:
http://dx.doi.org/10.4238/2015.April.10.18
Human Genetics   Research Article

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis

Authors: X.L. Zhang, X.J. Zhang, Y. Chen, Y.M. Zhang, Q. Zhang,C.X. Cao, D.Y. Gu, J.F. Shi, Y.L. Gong, J.F. Chen and C.J. Tang

A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was signifi cantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this p.. Read More»

Genet. Mol. Res. 13(1):
http://dx.doi.org/2014.February.28.10
DOI:
http://dx.doi.org/10.4238/2014.February.28.10
Human Genetics   Research Article

Study of the radiotherapy sensitization effects and mechanism of capecitabine (Xeloda) against non-small-cell lung cancer cell line A549

Authors: J.J. Zhu, J.J. Shan, L.B. Sun1 and W.S. Qiu

The purpose of this study was to explore the radiotherapy sensitization effects and the mechanism of capecitabine (Xeloda) against the non-small-cell lung cancer cell line, A549. γ-[60Co] radiation was used as the intervention method. Proliferative inhibition of capecitabine on A549 cells was determined by the CCK-8 method. The effects of capecitabi.. Read More»

Genet. Mol. Res. 14(4):
2015
DOI:
10.4238/2015
Human Genetics   Research Article

Relationship between genetic polymorphism of MCP-1 and non-small-cell lung cancer in the Han nationality of North China

Authors: L. Yang, G.L. Shi, C.X. Song and S.F. Xu

Monocyte chemoattractant protein 1 (MCP-1) is an important chemokine that has a dose-dependent anti-tumoral effect. Polymorphism in the MCP-1 distal regulatory region (-2518A/G) can affect the level of MCP-1 expression. We examined the polymorphisms of 112 unrelated patients with non-small-cell lung cancer (NSCLC) and 82 unrel.. Read More»

Genet. Mol. Res. 9(2):
vol9-2gmr740
DOI:
10.4238/vol9-2gmr740
Human Genetics   Research Article

Correlation of spicule sign on computed tomography scans with peripheral lung cancers associated with interstitial lung disease and chronic obstructive pulmonary disease

Authors: L. Chen, L. Gao and W.L. Wu

The objective of this study was to investigate the correlation between spicular signs on computed tomography (CT) scans and peripheral lung cancer (PLC) that is associated with interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). We analyzed clinical data from 96 PLC cases and grouped patients based on whether they had interst.. Read More»

Genet. Mol. Res. 14(1):
2015.March.27.9
DOI:
10.4238/2015.March.27.9
Human Genetics   Research Article

miR-129b suppresses cell proliferation in the human lung cancer cell lines A549 and H1299

Authors: L. Zheng, Y.X. Qi, S. Liu, M.L. Shi and W.P. Yang

Lung cancer is one of the most prevalent malignant tumors, and is one of the primary causes of cancer-associated deaths. In 2002, an estimated 1.18 million lung cancer-associated deaths were recorded, accounting for 18% of cancer-related deaths and 2% of total mortality. Despite the great progress that has been made in lung ca.. Read More»

Genet. Mol. Res. 15(4):
gmr15048367
DOI:
10.4238/gmr15048367
Human Genetics   Research Article

Serum microRNA-135a downregulation as a prognostic marker of non-small cell lung cancer

Authors: Y.K. Zhang, B. Sun and G. Sui

Abnormal expression of microRNA-135a (miR-135a) is closely associated with oncogenesis. However, the relationship between serum miR-135a levels and the clinical parameters and prognosis of non-small cell lung cancer (NSCLC) remain unclear. The study aimed to investigate the clinical significance of serum miR-135a expression in patients with NSCLC. miR-135.. Read More»

Genet. Mol. Res. 15(3):
gmr.15038252
DOI:
10.4238/gmr.15038252
Animal Genetics   Research Article

Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model

Authors: Q.-F. Gui, H.-F. Lu, C.-X. Zhang, Z.-R. Xu and Y.-M. Yang

The intestinal microflora affects inflammation and immunity, not only locally at the mucosal level but also systemically, raising the question of whether the microflora affects inflammatory processes that contribute to cancer and its therapy. Prebiotics have also been found to play an antitumor role that is not limited to the gut. We investigated the anti.. Read More»

Genet. Mol. Res. 14(2):
2015.May.25.16
DOI:
10.4238/2015.May.25.16
Human Genetics   Research Article

Combination of IL-6, IL-10, and MCP-1 with traditional serum tumor markers in lung cancer diagnosis and prognosis

Authors: Y.W. Pan, Z.G. Zhou, M. Wang, J.Q. Dong, K.P. Du, S. Li, Y.L. Liu, P.J. Lv and J.B. Gao

Early detection and treatment is critically important for lung cancer patients. Inflammatory mediators such as IL-6, IL-10, and MCP-1 participate in lung cancer regulation. CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. In this study, we assessed the sensitivity and specificity of CEA, CA125, and.. Read More»

Genet. Mol. Res. 15(4):
gmr15048949
DOI:
10.4238/gmr15048949
Human Genetics   Research Article

Correlation between gene polymorphisms of CYP1A1, GSTP1, ERCC2, XRCC1, and XRCC3 and susceptibility to lung cancer

Authors: H.X. Liu, J. Li and B.G. Ye

Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual’s genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308.. Read More»

Genet. Mol. Res. 15(4):
gmr15048813
DOI:
10.4238/gmr15048813