Lung Cancer

STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer

Authors: B. Jiang, Z.Z. Zhu, F. Liu, L.J. Yang, W.Y. Zhang, H.H. Yuan, J.G. Wang, X.H. Hu and G. Huang

Signal transducer and activator of transcription protein 3 (STAT3) has been implicated in cancer development and is recognized as a type of oncogene. However, association studies of single nucleotide polymorphisms (SNPs) in the STAT3 gene with cancer risk are rare and not available for lung cancer. We examined whether STAT3 po.. Read More»

Genet. Mol. Res. 10(3):

vol10-3gmr1071

DOI:

10.4238/vol10-3gmr1071

RETRACTION of â�?�?Correlation analysis between an IL-6 genetic polymorphism and non-small cell lung cancer prognosisâ�?, by Zhao K, Xu J, Tian H published in Genetics and Molecular Research 15 (1): 15017021 (2016) DOI: 10.4238/gmr.15017021

Authors: Zhao K, Xu J and Tian H

Genet. Mol. Res. 15(4):

gmr150470211

DOI:

10.4238/gmr150470211

Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma

Authors: X.F. Chen, S. Cai, Q.G. Chen, Z.H. Ni, J.H. Tang, D.W. Xu and X.B. Wang

Recent studies have shown that 5p15.33 is one of the chromosomal regions that is most consistently altered in lung cancer; common variants that are located in this region have been genotyped in various populations. However, the genetic contribution of these variants to carcinogenesis is relatively unknown. A clinic-based case-.. Read More»

Genet. Mol. Res. 11(1):

2012.February.16.2

DOI:

10.4238/2012.February.16.2

Correlation of MSH3 polymorphisms with response and survival in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy

Authors: X.-L. Xu, Y.-L. Yao, W.-Z. Xu, J.-G. Feng and W.-M. Mao

Mismatch repair (MMR) genes, as well as the nucleotide excision repair genes, play an important role in removing cisplatin-DNA adducts, and the mutation of MMR genes in tumors can lead to a decreased response to platinum-based therapies. We examined MutS homolog 3 (MSH3), a mismatch repair gene, and whether polymorphisms of MSH3 were associated with respo.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.15.16

DOI:

http://dx.doi.org/10.4238/2015.April.15.16

Role of TGFB1 polymorphism in the development of metastatic brain tumors in non-small cell lung cancer patients

Authors: H.B. Wang, W.G. Song, H.Q. Liu, F. Fang and Y. Xiao

We conducted a case-control study to investigate the role of 3 single-nucleotide polymorphisms of the gene encoding transforming growth factor-b1 (TGFB1) in the development of metastatic brain tumors in non-small cell lung cancer patients. The polymorphisms in TGFB1 rs4803455, rs1800469, and rs1800470 were evaluated by polymerase chain reaction-restrictio.. Read More»

Genet. Mol. Res. 14(2):

http://dx.doi.org/2015.April.17.3

DOI:

http://dx.doi.org/10.4238/2015.April.17.3

Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population

Authors: W.Y. Gan, H.M. Li, Y.G. Zhang, C.M. Li and Y. Wang

Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression.. Read More»

Genet. Mol. Res. 15(4):

gmr15048822

DOI:

10.4238/gmr15048822

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Authors: Y.Q. Jiang, X.P. Xu, Q.M. Guo, X.C. Xu, Q.Y. Liu, S.H. An, J.L. Xu, F. Su and J.B. Tai

Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer c.. Read More»

Genet. Mol. Res. 15(3):

gmr.15038336

DOI:

10.4238/gmr.15038336

Quantitative assessment of the effects of the EPHX1 Tyr113His polymorphism on lung and breast cancer

Authors: X. Tan, Y.Y. Wang, X.Y. Chen, L. Xian, J.J. Guo1, G.B. Liang and M.W. Chen

The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-a.. Read More»

Genet. Mol. Res. 13(3):

2014.September.12.10

DOI:

10.4238/2014.September.12.10

MTHFR C677T and A1298C polymorphisms and risk of lung cancer: a comprehensive evaluation

Authors: Y. Yang, L.J. Yang, M.Z. Deng, Y.Y. Luo, S. Wu, L. Xiong, D. Wang,Y. Liu and H. Liu

Results from previous studies on the association between methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and lung cancer have been conflicting. The aim of this meta-analysis was to clarify the effect of MTHFR polymorphisms on the risk of lung cancer. An electronic search of PubMed, EMBASE, the Cochra.. Read More»

Genet. Mol. Res. 15(2):

gmr.15027615

DOI:

10.4238/gmr.15027615

A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer

Authors: Z.Y. Zhang, Y. Xuan, X.Y. Jin, X. Tian and R. Wu

The caspase (CASP) gene family is known to be involved in apoptosis, cytokine maturation, cell growth, and differentiation. A large number of single nucleotide polymorphisms (SNPs) in the CASP gene family have been increasingly recognized as important regulators in the development of lung cancer. However, this specific association is still controversial. .. Read More»

Genet. Mol. Res. 12(3):

2013.January.4.22

DOI:

10.4238/2013.January.4.22