Lung Cancer
MicroRNA-154 functions as a tumor suppressor and directly targets HMGA2 in human non-small cell lung cancer
Authors: H.C. Zhuo, Y.F. Song, J. Ye, G.X. Lai and D.L. Liu
MicroRNA-154 (miR-154) is dysregulated in some human malignancies and is correlated with tumor progression. However, its expression and function in non-small cell lung cancer (NSCLC) remain unclear. Therefore, we explored the effects of miR-154 on NSCLC tumorigenesis and development. Using quantitative reverse transcription-po.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028173
- DOI:
- 10.4238/gmr.15028173
Association between survivin gene promoter -31G/C and -644C/T polymorphisms and non-small cell lung cancer
Authors: E. Aynaci, E. Coskunpinar, A. Eren, O. Kum, Y.M. Oltulu, N. Akkaya, A. Turna, I. Yaylim and P. Yildiz
Lung cancer is the most common cancer worldwide. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. The survivin gene is located on human chromosome 17q25, which is composed of 142 amino acids. A common polymorphism of the survivin gene promoter -31G/C has been shown to.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.February.28.9
- DOI:
- 10.4238/2013.February.28.9
Inhibitory effect of ursolic acid and oleanolic acid from Eriobotrya fragrans on A549 cell viability in vivo
Authors: Y.S. Gao, Y. Yuan, G. Song and S.Q. Lin
Loquat [Eriobotrya japonica (Lindl.)] is a traditional Chinese medicine, which has been used as an anti-inflammatory and for curing chronic bronchitis among other potential applications. Extracted ursolic acid (UA) and oleanolic acid (OA) from wild loquat were previously found capable of suppressing the proliferation of A549 c.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028642
- DOI:
- 10.4238/gmr.15028642
Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity
Authors: H. Tian, X. He, L. Yin, W.J. Guo, Y.Y. Xia and Z.X. Jiang
The aim of this study was to examine the relationship between genetic polymorphisms in DNA ligase 1 (LIG1) and nonsmall cell lung cancer (NSCLC) susceptibility and radiosensitivity in a Chinese population. This was a case-control study that included 352 NSCLC patients and 448 healthy controls. Polymerase chain reactionrestriction fragment length polymorph.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.14
- DOI:
- 10.4238/2015.June.26.14
Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299
Authors: G.M. Chen,R.F. Ding,Y.D. Tan,X.B. Pan,G.M. Jiang,J.F. He,S.H. Lin,C. Liu and Y. Jia
Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.15
Analyzing the association between XRCC1 c.1804C>A genetic variant and lung cancer susceptibility in the Chinese population
Authors: J.J. Jin, H.Q. Wang, H.P. Kuang, B.B. Kang, Y.H. Liu and J. Wang
Lung cancer is the most common cancer occurring worldwide. The human X-ray repair complementing group 1 (XRCC1) gene is one of the most important candidate genes that influence the susceptibility to lung cancer. The objective of this study was to analyze the potential association between the c.1804C>A genetic variant of XRC.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15024661
- DOI:
- 10.4238/gmr.15024661
Association between the XPG gene Asp1104His polymorphism and lung cancer risk
Authors: B. Zhou, X.M. Hu and G.Y. Wu
It has been suggested that the xeroderma pigmentosum complementation group G (XPG) gene Asp1104His polymorphism is linked to susceptibility to lung cancer. However, the results from the published studies are contradictory rather than conclusive. With this meta-analysis, we aimed to achieve a better understanding of the effects.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027395
- DOI:
- 10.4238/gmr.15027395
Changes in T-lymphocytes in lung cancer patients after hyperthermic intraperitoneal chemotherapy or radiotherapy
Authors: L. Yan, M. Wu, N. Ba, G. Shi, L. Wang and H. Zhang
We investigated dynamic changes in T-lymphocyte subsets after hyperthermic intraperitoneal chemotherapy (HIPEC) or radiotherapy using flow cytometry. A total of 1423 lung cancer patients admitted to our hospital between October 2012 and July 2015 were enrolled, and age-matched healthy individuals served as controls. Peripheral.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027865
- DOI:
- 10.4238/gmr.15027865
Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk
Authors: J. Ren, B.Z. He, T.S. Zhang, S.P. Lu and T. Yan
The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds rati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028353
- DOI:
- 10.4238/gmr.15028353
AGER genetic polymorphisms increase risks of breast and lung cancers
Authors: N.C. Yin, X.P. Lang, X.D. Wang and W. Liu
We evaluated the associations between three common polymorphisms in the AGER gene and the risks of breast (BC) and lung (LC) cancer using meta-analysis. A systematic electronic search of the literature was conducted to identify all potential correlation studies in Embase, Web of Science, Cochrane Library, CINAHL, PubMed, CISCOM, China BioMedicine (CBM), a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.2
- DOI:
- 10.4238/2015.December.22.2