Lung Cancer
Elevated expression of CXCR4 and correlation with clinicopathological features and prognosis of non-small cell lung cancer patients: a meta-analysis
Authors: H. Wang, F. Xie, Z. Hu and L. Chen
The specific correlation between CXCR4 expression and survival in non-small cell lung cancer (NSCLC) has been investigated independently; however, these have yielded inconsistent results. Therefore, we examined the exact relationship between CXCR4 expression and NSCLC in this meta-analysis. The bibliographic databases in English and Chinese were carefully.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.14
- DOI:
- 10.4238/2015.December.22.14
High expression of HIF-2�± and its anti-radiotherapy effect in lung cancer stem cells
Authors: J.C. Sun, F. He, W. Yi, M.H. Wan, R. Li, X. Wei, R. Wu and D.L. Niu
Hypoxia-inducible factor-2 alpha (HIF-2α) has been shown to regulate cell stemness, although the expression and effects of HIF-2α in lung cancer stem cells remained unclear. This study investigated HIF-2α expression in lung cancer stem cells, as well as the relationship between HIF-2α expression and radioresistance in lung cancer c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.37
- DOI:
- 10.4238/2015.December.22.37
Study of the methylation patterns of the EGFR gene promoter in non-small cell lung cancer
Authors: Z.Y. Pan, Z.S. Jiang and H.Q. Ouyang
We investigated the methylation state of the epidermal growth factor receptor (EGFR) gene promoter in non-small cell lung cancer (NSCLC) and analyzed its effect on tumor biology. We enrolled 120 patients with NSCLC who had been confirmed by pathologic diagnosis and had been operated on. The methylation states of the EGFR gene promoter were detected and an.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.14
- DOI:
- 10.4238/2015.August.19.14
Effects of microwave ablation or its combination with whole-body chemotherapy on serum vascular endothelial growth factor levels in patients with stage IIIB/IV NSCLC
Authors: Y.H. Sun, P.Y. Song, Y. Guo, M. Pang, W.-N. He, W.H. Zhang and L.J. Sheng
We aimed to analyze the changes of serum vascular endothelial growth factor (VEGF) before and after microwave ablation (MWA) in patients with stage IIIB-IV non-small cell lung cancer (NSCLC), and to observe the effects of MWA combined with chemotherapy on short-term therapeutic efficacy and long-term survival. Concentrations of serum VEGF in 20 healthy su.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.8
- DOI:
- 10.4238/2015.August.21.8
A clinical study evaluating dendritic and cytokine-induced killer cells combined with concurrent radiochemotherapy for stage IIIB non-small cell lung cancer
Authors: X.P. Zhu, Y.H. Xu, J. Zhou and X.F. Pan
To compare the efficacy of dendritic and cytokine-induced killer cells (DC-CIK) therapy combined with concurrent radiochemotherapy on stage IIIB non-small cell lung cancer. Sixty-three patients with stage IIIB non-small cell lung cancer were randomly divided into the study and control groups. The study group, comprising 30 patients, was treated with DC-CI.. Read More»
- Genet. Mol. Res. 14(3):
Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer
Authors: J.Y. Liu, Q.M. Liu and L.R. Li
We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.19
- DOI:
- 10.4238/2015.August.28.19