Macrophages
Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases
Authors: S.Q. Shen, R. Wang and S.G. Huang
Stem cell factor (SCF), an important stem cell cytokine, has multiple functions. Fibroblasts (FBs), mature mast cells, endothelial cells (ECs), and eosinophil granulocytes can produce SCF in the inflammatory process. Therefore, we aimed to observe SCF expression in FBs, ECs, and macrophages (MPs) in periapical tissues in human.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019394
- DOI:
- 10.4238/gmr16019394
Role of IL-10 and TNF-�± during Mycobacterium tuberculosis infection in murine alveolar macrophages
Authors: J. Shi, B.H. Sun, L.R. Zhou and X.S. Wang
Mycobacterium tuberculosis (Mtb) is known to be responsible for tuberculosis (TB), but the pathogenesis of this disease and the host defense mechanisms involved are, for the most part, poorly understood. In this study, we divided 30 male C57BL/6 mice into control and infection groups, and following injection with physiological saline or Mtb, respectively,.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037819
- DOI:
- 10.4238/gmr.15037819
Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway
Authors: Y.Q. Ren,Y.B. Zhou
This study aims to investigate the effects of andrographolide (AGP) on osteoclast formation in RAW 264.7 murine macrophage cells. The effects of AGP on cell viability were determined in RAW 264.7 cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The effects of AGP on osteoclast formation.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.7
- DOI:
- 10.4238/2015.December.7.7
Intracellular survival of virulence and low-virulence strains of Vibrio parahaemolyticus in Epinephelus awoara macrophages and peripheral leukocytes
Authors: X.J. Xu, B.H. Sang, W.B. Chen, Q.P. Yan, Z.Y. Xiong, J.B. Su and W.Z. Zou
In this study, we examined the virulence factors and pathogenesis of Vibrio parahaemolyticus in Epinephelus awoara. The chemotactic motility of V. parahaemolyticus for phagocytosis and intracellular survival in fish macrophages was determined using virulence strains and low-virulence strains of V. parahaemolyticus. We found that the intracellular mean num.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.14
- DOI:
- 10.4238/2015.January.30.14
Low polymorphism revealed in new microsatellite markers for Bemisia tabaci (Hemiptera: Aleyrodidae)
Authors: N. Jiang Y.H. Zheng X.J. Chen C. Qiu X.F. Zhang S.H. Wen G.X. Bian
Suppression subtractive hybridization was used to analyze differential expression of genes in rat peritoneal macrophages after granulocyte macrophage colony-stimulating factor treatment. We identified and cloned the mouse C10 analog gene in the rat, and named it as ccl6. The full-length cDNA of rat ccl6 was 467 bp, which contains a single-open reading frame .. Read More»
- Genet. Mol. Res. 11(4):
- 2012.November.12.6
- DOI:
- 10.4238/2012.November.12.6
LECT2 association with macrophage-mediated killing of Helicobacter pylori by activating NF-�ºB and nitric oxide production
Authors: H.X. Shen, L. Li, Q. Chen, Y.Q. He, C.H. Yu, C.Q. Chu, X.J. Lu and J. Chen
Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activa.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048889
- DOI:
- 10.4238/gmr15048889
Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases
Authors: Z.-Z. Liang, J. Li, S.-G. Huang
The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019329
- DOI:
- 10.4238/gmr16019329
Prognostic significance of tumor-associated macrophage infiltration in gastric cancer: a meta-analysis
Authors: X.L. Wang, J.T. Jiang and C.P. Wu
Tumor-associated macrophages (TAMs), which play a crucial role in the tumor microenvironment, can be divided into M1 and M2 phenotypes, these phenotypes may exert opposite effects on the prognoses of patients with gastric cancer (GC). The association between TAMs and GC is contentious. Thus, a meta-analysis of 12 studies (inco.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049040
- DOI:
- 10.4238/gmr15049040
Hemerythrin is required for Aeromonas hydraphlia to survive in the macrophages of Anguilla japonica
Authors: W.B. Zeng, W.B. Chen, Q.P. Yan, G.F. Lin and Y.X. Qin
Survival in host phagocytes is an effective strategy for pathogenic microbes to spread. To understand the mechanisms of Aeromonas hydrophila survival within host macrophages, a library of mini-Tn10 transposon insertion mutants was constructed. The M85 mutant, whose survival in host macrophages was only 23.1% of that of the wil.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028074
- DOI:
- 10.4238/gmr.15028074
Silencing effect of lentiviral vectors encoding shRNA of Herp on endoplasmic reticulum stress and inflammatory responses in RAW 264.7 macrophages
Authors: F.L. Chen, Q. Li, J.Y. Zhang1,, L.J. Lei, Z. Zhang, T.N. Mahmoud, X.G. Wang, P.F. Lin, Y.P. Jin and A.H. Wang
Herp, a mammalian protein with a ubiquitin-like domain, can be strongly upregulated by endoplasmic reticulum (ER) stress during ER-associated protein degradation. However, the other cellular functions of Herp remain unclear. We explored the effect of Herp on ER stress and inflammatory responses in RAW 264.7 macrophages that had been exposed to tunicamycin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.31
- DOI:
- 10.4238/2015.December.21.31