Mgmt
Glioblastoma in a 20-year-old female patient after Chikungunya infection
Authors: L.O. Mour�£o, L. Delmonico, A.S. Moreira, K.R. Bulsara, T. Da Luz, R.T. Silvestre, A.C.B. Koifman, L.C. Guida, G.N. Soares, M.G.C. Carvalho, M.H. Ornellas and G. Alves
We describe the case of a 20-year-old female patient who died 4 months after the diagnosis of a glioblastoma (GBM). The tumor emerged nearly a month after a Chikungunya (CHIKV) infection and displayed positivity to Citomegalovirus (CMV) DNA. The immunohistochemical studies revealed GFAP positivity in rare cells, IDH-1 positive, vimentin positive, ATRX pos.. Read More»
- Genet. Mol. Res. 18(1):
Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer
Authors: J. Jin, L. Xie, C.H. Xie and Y.F. Zhou
We aimed to explore the association between aberrant DNA methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) genes with gastric cancer. A total of 283 gastric cancer patients who were confirmed by pathological diagnosis were included in our study. Aberrant DNA methylation of MGMT.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.9
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.9
Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels
Authors: N. Liu1, J. Jiang1, Y.J. Song2, S.G. Zhao3, Z.G. Tong4, H.S. Song1, H. Wu1, J.Y. Zhu1, Y.H. Gu1, Y. Sun1, W. Hua1 and J.P. Qi1
Hypomethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter in glioma cells has been associated with temozolomide resistance. S-adenosylmethionine (SAM), which is produced during folate metabolism, is the main source of methyl groups during DNA methylation... Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.29.10
- DOI:
- 10.4238/2013.October.29.10
Production of human factor VIII-FL in 293T cells using the bicistronic MGMT(P140K)-retroviral vector
Authors: A.M. Fontes, F.U.F. Melo, L.J. Greene, V.M. Fa�§a, Y. Lin, S.L. Gerson and D.T. Covas
Hemophilia A is the most common X-linked bleeding disorder; it is caused by deficiency of coagulation factor VIII (FVIII). Replacement therapy with rFVIII produced from human cell line is a major goal for treating hemophilia patients. We prepared a full-length recombinant FVIII (FVIII-FL), using the pMFG-P140K retroviral vecto.. Read More»
- Genet. Mol. Res. 11(1):
- 2012.March.22.8
- DOI:
- 10.4238/2012.March.22.8