Microrna
MicroRNAs as biomarkers of kidney allograft injuries ischemia reperfusion and acute rejection
Authors: Patricia Milhoransa, Carolina Caruccio Montanari, Mariane Dos Santos, Marina Sieber, Roberto Ceratti Manfro
Renal transplantation provides a significant increase in life expectancy for patients with end-stage kidney diseases. Despite the unequivocal progresses made in the last decades, many grafts injuries still jeopardize graft function leading to its loss. Currently, the allograft biopsy is the gold standard for diagnosing such conditions. However, it has man.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039933
- DOI:
- http://dx.doi.org/10.4238/gmr16039933
In silico identification and target prediction of micrornas in Sesame (sesamum indicum L.) expressed sequence tags
Authors: Halak Joshi and M. K. Mandavia
Sesame (Sesamum indicum L.), a member of the Pedaliaceae family, is one of the oldest oilseed crops. For its high oil content, it is known as the “queen of oilseeds”. MicroRNAs (miRNAs) represent a class of endogenous non-coding small RNAs that play important roles in multiple biological processes by degrading targ.. Read More»
- Genet. Mol. Res. 17(2):
- gmr16039911
- DOI:
- 10.4238/gmr16039911
Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological approaches for precision medicine
Authors: Fehmida Bibi, Peter Natesan Pushparaj, Muhammad I. Naseer, Muhammad yasir, Esam I. Azhar
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate the differential expression of genes. The expression of miRNAs is dysregulated in various types of cancers, including Gastric Cancer (GC), and has both prognostic and diagnostic potential. To interpret the role of miRNA expression in GC, we evaluated the expre.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039845
- DOI:
- 10.4238/gmr16039845
Suppression of the biological activity of neuroglioma cells by down-regulation of miR-1
Authors: Y.Q. Wang, Y. Cai and X.M. Zhong
Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regula.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039256
- DOI:
- 10.4238/gmr16039256
Bioinformatic analysis of miRNA expression patterns in TFF2 knock-out mice
Authors: Y. Yin, H.Q. Shan, W. Huang, Y.M. Wu, H. Lu and Y. Jin
Trefoil factors, which bear a unique 3-loop trefoil domain, are a family of small secretory protease-resistant peptides (7-12 kDa) discovered in the 1980s. Trefoil factor 2 (TFF2) is a unique member of trefoil factors family that plays important roles in gastrointestinal mucosal defense and repair. However, few studies have characterized the miRNA express.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.26
- DOI:
- 10.4238/2014.October.20.26
Prediction of potential novel microRNAs in soybean when in symbiosis
Authors: G.A. Barros-Carvalho1,2, A.R. Paschoal3, F.C. Marcelino-Guimar�£es1 and M. Hungria1
MicroRNAs (miRNAs) are small molecules, noncoding proteins that are involved in many biological processes, especially in plants; among these processes is nodulation in the legume. Biological nitrogen fixation is a key process, with critical importance to the soybean crop. This study aimed to identify the potential of novel miRNAs to act during the root no.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.28
- DOI:
- 10.4238/2014.October.20.28
Identification of UV-B-induced microRNAs in wheat
Authors: B. Wang*, Y.F. Sun*, N. Song, X.J. Wang, H. Feng, L.L. Huang and Z.S. Kang
MicroRNAs (miRNAs) play critical roles in post-transcriptional gene regulation and act as important endogenous regulators to various stressors. Ultraviolet-B (UV-B) radiation is a major factor influencing crop growth and development. In this study, we isolated a novel wheat miRNA, named Tae-miR6000, and confirmed its expression diversity after UV-B treatm.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.7.7
- DOI:
- 10.4238/2013.October.7.7
Inhibitory effect of microRNA-24 on fatty acid-binding protein expression on 3T3-L1 adipocyte differentiation
Authors: M. Kang1*, L.M. Yan2*, Y.M. Li3, W.Y. Zhang3, H. Wang3, A.Z. Tang1 and H.S. Ou3
We examined the effect of microRNAs on 3T3-L1 adipocyte differentiation and expression of adipocyte-specific gene fatty acid-binding protein 4 (FABP4). We screened and identified adipo-related microRNAs during 3T3-L1 adipocyte differentiation with a microRNA microarray. High expression plasmids of miR-24 and miR-21 were constructed and transfected into 3T.. Read More»
- Genet. Mol. Res. 13(4):
- 2013.November.7.1
- DOI:
- 10.4238/2013.November.7.1
MicroRNA expression profiling studies on bronchopulmonary dysplasia: a systematic review and meta-analysis
Authors: Y. Yang, J. Qiu, Q. Kan, X.-G. Zhou and X.-Y. Zhou
Over the past several years, several microRNA (miRNA) expression profiling studies have been carried out on bronchopulmonary dysplasia (BPD) in mammalian lung tissues. The most effective way to identify these important miRNAs is to systematically search for similar signatures identified in multiple independent studies. Accordingly, a meta-analysis was con.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.30.4
- DOI:
- 10.4238/2013.October.30.4
Predicting the target genes of microRNA based on microarray data
Authors: B. Cao, T. Ji, B. Zhou, J. Zou, G.Q. Jiao
MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides in length, which play important roles in regulating gene expression post-transcriptionally. Several computational methods and algorithms have been developed to predict miRNA targets. In this study, we described a method that can be used to integrate m.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.2.4
- DOI:
- 10.4238/2013.December.2.4