Microrna
New support vector machine-based method for microRNA target prediction
Authors: L. Li, Q. Gao, X. Mao and Y. Cao
MicroRNA (miRNA) plays important roles in cell differentiation, proliferation, growth, mobility, and apoptosis. An accurate list of precise target genes is necessary in order to fully understand the importance of miRNAs in animal development and disease. Several computational methods have been proposed for miRNA target-gene id.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.3
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.3
Isolation and expression analysis of four HD-ZIP III family genes targeted by microRNA166 in peach
Authors: C.H. Zhang, B.B. Zhang, R.J. Ma, M.L. Yu, S.L. Guo and L. Guo
MicroRNA166 (miR166) is known to have highly conserved targets that encode proteins of the class III homeodomain-leucine zipper (HD-ZIP III) family, in a broad range of plant species. To further understand the relationship between HD-ZIP III genes and miR166, four HD-ZIP III family genes (PpHB14, PpHB15, PpHB8, and PpREV) were isolated from peach (Prunus .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.37
- DOI:
- 10.4238/2015.October.29.37
Regulation of the expression of zinc finger protein genes by microRNAs enriched within acute lymphoblastic leukemia-derived microvesicles
Authors: L. Lu, X.M. Chen, H.M. Tao, W. Xiong, S.H. Jie and H.Y. Li
Microvesicles (MVs) are submicrometric membrane fragments that can “engulf” cytoplasmic contents such as microRNAs (miRNAs) from their cellular origin. The study of miRNAs carried within MVs might provide insights into the roles that miRNAs play in the underlying pathophysiologic processes of acute lymphoblastic le.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.2
- DOI:
- 10.4238/2015.October.5.2
Inhibition of invasion and migration of prostate cancer cells by miRNA-509-5p via targeting MDM2
Authors: X.M. Tian, Y.Z. Luo, P. He, J. Li, Z.W. Ma and Y. An
Prostate cancer is a common malignancy of the male reproductive-urinary system. MDM2 is an oncogene, whose expression can be regulated by microRNA (miRNA). The present study investigated the expression and correlation of miRNA-509-5p and MDM2 to determine the mechanism of their function in invasion and migration of prostate ca.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019195
- DOI:
- 10.4238/gmr16019195
MicroRNA expression profile of a Malaysian Bajau family with familial mitochondrial neurogastrointestinal encephalomyopathy
Authors: F.L. Yong, C.W. Wang and K.S. Tan
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare, autosomal recessive disorder associated with mutations in the thymidine phosphorylase (TYMP) gene. The main objective of this study was to characterize the genetic profiles of the deceased proband’s family members (N = 4) using DNA sequencing and to determine miRNA deregulation.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.13
- DOI:
- 10.4238/2015.October.26.13
MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice
Authors: L. Song, Z.R. Zhang, J.L. Zhang, X.B. Zhu, L. He, Z. Shi, L. Gao, Y. Li, B. Hu and F.M. Feng
Many studies have shown that the pathogenesis of liver injury includes oxidative stress. MicroRNA-122 may be a marker for the early diagnosis of drug-induced liver injury. However, the relationship between microRNA-122 and oxidative stress in anti-tuberculosis drug-induced liver injury remains unknown. We measured changes in tissue microRNA-122 levels and.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.22
- DOI:
- 10.4238/2015.October.26.22
Assessing potential miRNA targets based on a Markov model
Authors: Hao-Yue Fu1,2, Ding-Yu Xue2, Xiang-de Zhang1 and Pei-Ying Yang2
At present, studies on microRNA mainly focus on the identification of microRNA genes and their mRNA targets. Although researchers have identified many microRNA genes, relatively few microRNA targets have been identified by experimental methods. Computational programs designed for predicting potential microRNA targets provide numerous targets for expe.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr604
- DOI:
- 10.4238/vol8-3gmr604
MicroRNA-139 modulates Alzheimer�s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2
Authors: Y. Tang, J.S. Bao, J.H. Su and W. Huang
Alzheimer’s disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as we.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019166
- DOI:
- 10.4238/gmr16019166
Alpaca fiber growth is mediated by microRNA let-7b via down-regulation of target gene FGF5
Authors: T. Wang, Y. Zhang, H.D. Wang, Y. Shen, N. Liu, J. Cao, X.J. Yu, C.S. Dong and X.Y. He
MicroRNAs are very small endogenous RNA molecules that play a crucial role in an array of biological processes, including regulation of skin morphogenesis. The microRNA let-7b is thought to modulate animal hair growth, by binding target genes that encode growth factors. Fibroblast growth factor 5 (FGF5) has been previously reported to be involved in the i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.38
- DOI:
- 10.4238/2015.October.28.38
Expression of microRNA-210 in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion
Authors: T.Y. Liu1, H. Zhang2, S.M. Du3, J. Li1 and X.H. Wen1
This study investigated the expression of microRNA-210 (miR-210) in tissue and serum of renal carcinoma patients and its effect on renal carcinoma cell proliferation, apoptosis, and invasion. Thirty-two renal carcinoma patients in our hospital were selected as the study group and 32 people receiving a physical examination were selected as the control grou.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017746
- DOI:
- 10.4238/gmr.15017746