Microrna
Characterization and expression analysis of microRNAs in Qira black sheep and Hetian sheep ovaries using Solexa sequencing
Authors: H. Shen, H.Y. Chen, B. Jia, G.H. Han, Y.S. Zhang and X.C. Zeng
The role of microRNAs (miRNAs) in the regulation of mammalian reproduction has been demonstrated previously. However, only a few studies have assessed the role of miRNAs in the reproduction processes of sheep. The elucidation of miRNA expression profiles in the ovaries of different sheep breeds representing fecundity extremes will be useful in understandi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.11
- DOI:
- 10.4238/2015.July.3.11
Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis
Authors: T.-Y. Wang, S.-G. Liu, B.-S. Zhao, B. Qi, X.-G. Qin and W.-J. Yao
The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman® MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.25.12
- DOI:
- 10.4238/2014.July.25.12
Protein interaction and microRNA network analysis in osteoarthritis meniscal cells
Authors: M. Wang, C. Liu, Y. Zhang, Y. Hao, X. Zhang and Y.M. Zhang
Osteoarthritis is the most common form of arthritis among elderly adults. Herein, we performed protein-protein interaction (PPI) and miRNA network analysis to evaluate the global correlation between miRNA regulation and the PPI network in human osteoarthritis. Our results showed that desmoplakin (DSP), cystatin A (CSTA), calmodulin 1, tyrosine kinase endo.. Read More»
- Genet. Mol. Res. 12(1):
- 2013
- DOI:
- 10.4238/2013
Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma
Authors: D. Li, J.J. Peng, Y. Tan, T. Chen, D. Wei, M. Du and T. Zhang
We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were ge.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.20.2
- DOI:
- 10.4238/2015.March.20.2
Characterization and comparison of flower bud microRNAs from yellow-horn species
Authors: Y. Ao
An increasing number of microRNAs (miRNAs) are known to play crucial regulatory roles in floral organ differentiation and development. Yellow-horn (Xanthoceras sorbifolia Bunge) is an oil-rich seed shrub that has great potential for biodiesel production. To evaluate the roles of miRNAs in the regulation of flower development, .. Read More»
- Genet. Mol. Res. 15(4):
- gmr.15048899
- DOI:
- 10.4238/gmr.15048899
Expression of microRNA-106b and its clinical significance in cutaneous melanoma
Authors: N. Lin, Y. Zhou, X. Lian and Y. Tu
MicroRNA-106b (miR-106b) is overexpressed in various types of cancers and is associated with the regulation of carcinogenic processes. However, its clinical significance in cutaneous melanoma has not been reported. qRT-PCR was performed to examine the expression of miR-106b in 15 cases of dysplastic nevi, 17 cases of melanoma metastases, and 97 cases of p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population
Authors: K. Yu, Y. Ji, H. Wang, Q.K. Xuan, B.B. Li, J.J. Xiao, W. Sun and X.Q. Kong
We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs8.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048929
- DOI:
- 10.4238/gmr15048929
Reduced miRNA-218 expression in pancreatic cancer patients as a predictor of poor prognosis
Authors: B.-S. Li, H. Liu and W.-L. Yang
microRNA-218 (miR-218) is a vertebrate-specific miRNA that plays a crucial role in tumorigenesis and tumor progression. This study analyzed the miR-218 expression level and clinical significance in pancreatic cancer. One hundred and seven pairs of pancreatic cancer and adjacent normal tissues were analyzed by quantitative reverse-transcriptase polymerase .. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Gynophore miRNA analysis at different developmental stages in Arachis duranensis
Authors: Y. Shen, Y.H. Liu, X.J. Zhang, Q. Sha and Z.D. Chen
Peanut is one of the most important oilseed crops in the world that provides a significant amount of lipids and protein for many people. The gynophore plays an important role in gynophore development after fertilization of the peanut ovule. MicroRNAs (miRNAs) play an important role in numerous developmental and physiological p.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048691
- DOI:
- 10.4238/gmr15048691
Benchmark comparison of ab initio microRNA identification methods and software
Authors: L.L. Hu Y. Huang Q.C. Wang Q. Zou Y. Jiang
MicroRNAs (miRNAs) are short, non-coding RNA molecules that play an important role in the world of genes, especially in regulating the gene expression of target messenger RNAs through cleavage or translational repression of messenger RNA. Ab initio methods have become popular in computational miRNA detection. Most software tools are designed to distinguish m.. Read More»
- Genet. Mol. Res. 11(4):
- 2012.October.17.4
- DOI:
- 10.4238/2012.October.17.4