Microrna
MicroRNA-338-3p inhibits glucocorticoid-induced osteoclast formation through RANKL targeting
Authors: X.H. Zhang, G.L. Geng, B. Su, C.P. Liang, F. Wang and J.C. Bao
The differentiation deficiencies of osteoclast precursors (pre-OCs) may contribute to osteoporosis. Research on osteoporosis has recently focused on microRNAs (miRNAs) that play crucial roles in pre-OC differentiation. In the current study, we aimed to analyze the expression and function of the glucocorticoid (GC)-associated miRNA-338-3p (miR-338-3p) in o.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037674
- DOI:
- 10.4238/gmr.15037674
MicroRNA variants and colorectal cancer risk: a meta-analysis
Authors: X.M. Pan, X. Xiao, H.J. Qin, Z. Zhang, Z.H. Li, L.B. Gao and J. Jia
Colorectal cancer (CRC) is a multi-factorial disease, and genetic background may contribute to its etiology. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may be used as specific markers of predisposition for CRC diagnosis and preventionIn this review, we summarize and discuss recent publications evaluating the .. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038478
- DOI:
- 10.4238/gmr.15038478
Identification of conserved microRNAs and their target genes in Nile tilapia (Oreochromis niloticus) by bioinformatic analysis
Authors: X.H. Li, J.S. Wu, L.H. Tang and D. Hu
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in posttranscriptional regulation of target genes. miRNAs are involved in multiple biological processes by degrading targeted mRNAs or repressing mRNA translation in various organisms. Their conserved nature in various organisms makes them a good source of new miRNA discovery usin.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.31.8
- DOI:
- http://dx.doi.org/10.4238/2015.March.31.8
Circulatory microRNA-145 expression is increased in cerebral ischemia
Authors: C.S. Gan, C.W. Wang and K.S. Tan
Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression .. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.27.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.27.1
Prediction and extraction of microRNA2target interactions associated with leukemia
Authors: L. Gong, Q. Yan, R. Yang and X. Sun
MicroRNAs are small, non-coding RNAs that regulate gene expression by suppressing mRNA translation or inducing mRNA degradation, and have been implicated in a growing number of diseases. To understand microRNAs’ function, it is vital to identify microRNA2target interactions. This work explores the prediction and extracti.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.19
- DOI:
- 10.4238/2014.March.24.19
Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis
Authors: Y.P. Gu, Q.Y. Yuan, H. Zhang, C.J. Wang and F. Zhou
Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.4
- DOI:
- 10.4238/2015.July.28.4
Downregulation of microRNA-630 inhibits cell proliferation and invasion and enhances chemosensitivity in human ovarian carcinoma
Authors: Y.T. Zou, J.Y. Gao, H.L. Wang, Y. Wang, H. Wang and P.L. Li
MicroRNAs (miRNAs) are a family of small non-coding RNAs (approximately 21-23 nt long) that can target genes for either degradation of mRNA or inhibition of translation. miRNAs have not been comprehensively studied in human epithelial ovarian carcinoma (EOC). MicroRNA-630 (miR-630) has been frequently observed to be aberrantly expressed in various types o.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.25
- DOI:
- 10.4238/2015.July.31.25
Drosha, DGCR8, and Dicer mRNAs are downregulated in human cells infected with dengue virus 4 - Genet. Mol. Res. 15 (2): gmr.15027891 Drosha, Dicer, and TRBP mRNA are downregulated in Vero cells with the 3 UTR of Dengue virus
Authors: J.A. Castillo and S. Urcuqui-Inchima
A recent paper (Casseb et al., 2016) published in the journal Genetics and Molecular Research described the interesting concept that dengue virus (DENV)-4 infection, in the human cell line A-549, leads to the downregulation of expression of key components of microRNA (miRNA) biogenesis, such as Drosha, Dicer, and DGCR8. For th.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15039050
- DOI:
- 10.4238/gmr.15039050
Identification and characterization of conserved microRNAs and their target genes in wheat (Triticum aestivum)
Authors: Z.J. Yin and F.F. Shen
MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression by translational repression or transcript degradation. A large number of miRNAs have been identified from model plant species; however, the character of conserved miRNAs is poorly understood. We studied 42 miRNA families that are conserved within the pl.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr805
- DOI:
- 10.4238/vol9-2gmr805
Association between a functional variant in microRNA-27a and susceptibility to colorectal cancer in a Chinese Han population
Authors: Y. Cao, J. Hu, Y. Fang, Q. Chen and H. Li
Polymorphisms in pri-, pre-, and mature-microRNAs (miRNAs) have been proposed to be associated with various human cancers. Common single nucleotide polymorphisms (SNPs) in miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Through genotyping the rs895819 SNP in 254 colorectal cance.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.8
- DOI:
- 10.4238/2014.September.12.8