Microrna
Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population
Authors: P. Qi, L. Wang, B. Zhou, W.J. Yao, S. Xu, Y. Zhou and Z.B. Xie
Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide poly.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.11.2
- DOI:
- 10.4238/2015.June.11.2
Prognostic significance of microRNA-10b overexpression in breast cancer: a meta-analysis
Authors: N. Wang, P. Chen, L.P. Huang and T.Z. Wang
Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-10b involvement in human breast cancer and analyze the predicting role of miR-10b for survival. We searched, Embase, and Wanfang d.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027350
- DOI:
- 10.4238/gmr.15027350
Deep RNA sequencing elucidates microRNA-regulated molecular pathways in ischemic cardiomyopathy and nonischemic cardiomyopathy
Authors: X. Li, C.Y. Liu, Y.S. Li, J. Xu, D.G. Li, X.I. Li and D. Han
Deregulation of cardiac miRNA gene-regulatory networks is a feature of different heart diseases, including ischemic (ICM) and nonischemic (NICM) cardiomyopathy. Here, based on the paired miRNA and mRNA expression profiles in ICM and NICM, we identified the differentially expressed miRNAs and mRNAs and the expression signatures.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027465
- DOI:
- 10.4238/gmr.15027465
Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer
Authors: L. Liu, T. Meng, Q.S. Wang, H.Z. Jin, Z.Q. Sun, B. Jin, F. Fang and H.J. Wang
We investigated the associations between Beclin-1 and microRNA-30a (miR-30a) expression and the severity and treatment response in colorectal cancer (CRC). Our sample size consisted of 139 CRC patients who were treated with surgery alone. Immunohistochemistry was used to investigate the expression and prognostic significance o.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027704
- DOI:
- 10.4238/gmr.15027704
Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells
Authors: T.J. Xing, H.T. Xu, W.Q. Yu and D.F. Jiang
The regulation mechanism and significance of microRNA-122 (miRNA-122) expression are unclear. The aim of this study was to investigate the effects of DNA methylation on liver-specific miRNA-122 expression, cell proliferation, and apoptosis in hepatocellular carcinoma. Methylation of the miRNA-122 promoter region was detected through methylation sequencing.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.13.3
- DOI:
- 10.4238/2013.September.13.3
Identification of miRNAs and their targets in wheat (Triticum aestivum L.) by EST analysis
Authors: J. Han, M.L. Kong, H. Xie, Q.P. Sun, Z.J. Nan, Q.Z. Zhang and J.B. Pan
MicroRNAs (miRNAs) are a newly discovered class of noncoding small RNAs that regulate gene expression by directing target mRNA cleavage or translational inhibition. A large number of miRNAs have been identified in plants. Increasing evidence has shown that miRNAs play multiple roles in plant biological processes. So far, identification of miRNAs has been .. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.11
- DOI:
- 10.4238/2013.September.19.11
miRQuest: integration of tools on a Web server for microRNA research
Authors: R.R. Aguiar, L.A. Ambrosio, G. Sep�?ºlveda-Hermosilla, V. Maracaja-Coutinho and A.R. Paschoal
This report describes the miRQuest - a novel middleware available in a Web server that allows the end user to do the miRNA research in a user-friendly way. It is known that there are many prediction tools for microRNA (miRNA) identification that use different programming languages and methods to realize this task. It is diffic.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016861
- DOI:
- 10.4238/gmr.15016861
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
Authors: X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017318
- DOI:
- 10.4238/gmr.15017318
MicroRNA analysis in model species based on evolutionary rates
Authors: X.F. Mao and Y.C. Cao
MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression. In an attempt to gain insights into miRNAs at the macroevolutionary level, we performed a systematic analysis of miRNAs in six model organisms based on their evolutionary rates. First, we calculated their miRNA evolutionary rates, and found that they did not correlate with th.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017216
- DOI:
- 10.4238/gmr.15017216
Computational identification and characterization of conserved miRNAs and their target genes in beet (Beta vulgaris)
Authors: J.L. Li, J. Cui and D.Y. Cheng
Highly conserved endogenous non-coding microRNAs (miRNAs) play important roles in plants and animals by silencing genes via destruction or blocking of translation of homologous mRNA. Sugar beet, Beta vulgaris, is one of the most important sugar crops in China, with properties that include wide adaptability and strong tolerance to salinity and impoverished.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.19
- DOI:
- 10.4238/2015.August.7.19