Microrna
Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma
Authors: Z.Y. Ni, F.O. Lin, D.F. Liu and J. Xiao
MicroRNA-143 serves as a tumor suppressor in many human malignancies. However, its involvement in oral squamous cell carcinoma (OSCC) is still unclear. In this study, we investigated the effects of miR-143 in OSCC tumorigenesis and development. Using real-time quantitative reverse transcription-polymerase chain reaction, we detected miR-143 expression in .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.2
- DOI:
- 10.4238/2015.June.26.2
Effects of conjugated linoleic acid on the expression levels of miR-27 and miR-143 inpig adipose tissue
Authors: R.L. Qi, Y. Chen, J.X. Huang andF.Y. Yang
In this study, we evaluated the effect and possible mechanism of action of dietary conjugated linoleic acid (CLA) on pig body fat deposition. Landrace piglets (N = 48) were randomly divided into three groups, which were fed diets containing 0% (control), 1%, or 2% CLA. Dorsal and abdominal subcutaneous adipose tissues were collected, and real-time polymer.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.7
- DOI:
- 10.4238/2015.June.26.7
Overregulation of microRNA-212 in the poor prognosis of esophageal cancer patients
Authors: B. Qi, S.G. Liu, X.G. Qin, W.J. Yao, J.G. Lu, L. Guo, T.Y. Wang, H.C. Li and B.S. Zhao
There have been few reports evaluating the expression and function of the microRNA miR-212 in esophageal cancer. The aim of this study was to investigate the relationship between miR-212 expression and clinicopathological factors and prognoses of esophageal cancer. MicroRNA was extracted from 46 esophageal cancer patients usin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.18
- DOI:
- 10.4238/2014.September.26.18
miR-204 suppresses non-small-cell lung carcinoma (NSCLC) invasion and migration by targeting JAK2
Authors: P. Wang, H.Y. Lv, D.M. Zhou and E.N. Zhang
Aberrant expression of microRNA is associated with the development and progression of cancers. MicroRNA-204 (miR-204) down-regulation has been previously demonstrated in non-small-cell lung carcinoma (NSCLC); however, the underlying mechanism by which miR-204 suppresses tumorigenesis in NSCLC remains elusive. In this study, mi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026415
- DOI:
- 10.4238/gmr.15026415
Upregulated microRNA-301a in osteosarcoma promotes tumor progression by targeting CDC14A
Authors: Z. Ni, X.F. Shang, Y.F. Wang, Y.J. Sun and D.J. Fu
MicroRNAs (miRs) are associated with tumor progression in various cancers, such as gastric and hepatic carcinomas, and lung cancer. miR-301a is overexpressed and displays oncogenic activity in cancers. We investigated the biological involvement of miR-301a in osteosarcoma (OS). Quantitative real-time polymerase chain reaction .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027807
- DOI:
- 10.4238/gmr.15027807
Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis
Authors: M. Zhang, L.J. Zhao, W.Q. Liang and Z.P. Mao
Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.3
- DOI:
- 10.4238/2015.December.11.3
Decreased microRNA-198 expression and its prognostic significance in human glioma
Authors: H.B. Man, W.P. Bi and H.H. Man
Previous evidence has shown the association of aberrant miR-198 expression with tumorigenesis and progression of many human malignancies. However, its involvement in human glioma is still unclear. Therefore, the aim of the current study was to investigate the expression and function of miR-198 in human gliomas. Using real-time.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027656
- DOI:
- 10.4238/gmr.15027656
Expression of miR-98 in myocarditis and its influence on transcription of the FAS/FASL gene pair
Authors: B.Y. Zhang, Z. Zhao and Z. Jin
Myocarditis is a common cardiovascular disease and frequently occurs in children and teenagers. It is believed to be caused by both endogenous and exogenous factors, among which FAS/FASL gene pair-induced cell apoptosis is a major mechanism of myocardial cell injury. A previous study has detected low expression of microRNA (mi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027627
- DOI:
- 10.4238/gmr.15027627
Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis
Authors: R.Q. Yang, H. Teng, X.H. Xu, S.Y. Liu, Y.H. Wang, F.J. Guo and X.J. Liu
We examined the aberrant microRNA (miRNA) expression profile responsible for the changes in angiogenesis observed in endometriotic lesions. This study revealed characteristic miRNA expression profiles associated with endometriosis in endometrial tissue and endometriotic lesions from the same patient, and their correlation with.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027826
- DOI:
- 10.4238/gmr.15027826
Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299
Authors: G.M. Chen,R.F. Ding,Y.D. Tan,X.B. Pan,G.M. Jiang,J.F. He,S.H. Lin,C. Liu and Y. Jia
Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.15