Microrna
Analysis and clinical significance of microRNA-499 expression levels in serum of patients with acute myocardial infarction
Authors: C.H. Zhao,G.-C. Cheng,R.L. He,Y. Hong,Q.L. Wan,Z.-Z. Wang and Z.-Y. Pan
The aim of this study was to investigate the expression level of microRNA-499 and its clinical significance in serum of patients with acute myocardial infarction (AMI). We recruited 59 patients with AMI and 60 healthy individuals undergoing physical examination in our hospital during the same period as controls. Peripheral blood was drawn in the morning o.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.17
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.17
MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG
Authors: J.J. Li,W.H. Chan,W.Y. Leung,Y. Wang and C.S. Xu
Rat liver regeneration (RLR) induced by partial hepatectomy involves cell proliferation regulated by numerous factors, including microRNAs (miRNAs). miRNA high-throughput sequencing has been established and used to analyze miRNA expression profiles. This study showed that 39 miRNAs were related to RLR through the analysis of miRNA high-throughput sequenci.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.30
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.30
MicroRNA profiling in cutaneous wounds of diabetic rats
Authors: Y.-F. Liu, M. Ding, D.-W. Liu, Y. Liu, Y.-G. Mao and Y. Peng
Despite years of effort, current therapies for diabetic wounds are still not fully efficacious. Emerging evidence has suggested that microRNAs (miRNAs) play key roles in multiple physiological and pathological processes in eukaryotes, and could potentially be powerful therapeutic tools. This study investigated the differential expression profiling of miRN.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.24
- DOI:
- 10.4238/2015.August.14.24
Characterization of microRNAs from goat (Capra hircus) by Solexa deep-sequencing technology
Authors: Y.H. Ling, J.P. Ding, X.D. Zhang, L.J. Wang, Y.H. Zhang, Y.S. Li, Z.J. Zhang and X.R. Zhang
MicroRNAs (miRNAs) are an important class of small noncoding RNAs that are highly conserved in plants and animals. Many miRNAs are known to mediate a myriad of cell processes, including proliferation and differentiation, via the regulation of some transcription and signaling factors, which are closely related to muscle development and disease. In this stu.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.4
- DOI:
- 10.4238/2013.June.13.4
miR-125a-5p expression is associated with the age of breast cancer patients
Authors: H. He, F. Xu, W. Huang, S.Y. Luo, Y.T. Lin, G.H. Zhang, Q. Du and R.H. Duan
Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NA.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.17
- DOI:
- 10.4238/2015.December.22.17
Diagnostic performance of microRNA-29a for colorectal cancer: a meta-analysis
Authors: M.L. Zhi, Z.J. Liu, X.Y. Yi, L.J. Zhang and Y.X. Bao
Previous studies have revealed that the expression level of microRNA-29a (miR-29a) was remarkably different in colorectal cancer (CRC) patients and healthy controls, indicating that miR-29a can be used as a diagnostic marker of CRC, but the results have been inconsistent. We conducted this meta-analysis to assess the diagnostic performance of blood-based .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.28
- DOI:
- 10.4238/2015.December.22.28
Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer
Authors: Y.B. Ma, G.X. Li, J.X. Hu, X. Liu and B.M. Shi
MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase cha.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.2
- DOI:
- 10.4238/2015.December.23.2
Analysis of the expression of HMGB-1, CXCL16, miRNA-30a, and TGF-�²1 in primary nephritic syndrome patients and its significance
Authors: W.J. Wang, X.Q. Qu, X.M. Yu, W. Lv and H.Y. Yu
We investigated the expression levels of high-mobility group box protein 1 (HMGB-1), CXC chemokine ligand 16 (CXCL16), microRNA (miRNA)-30a and transforming growth factor b1 (TGF-b1) in primary nephritic syndrome (PNS) patients and the clinical significance of this expression. A total of 56 patients with PNS were included in the PNS group, while 50 health.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.17
- DOI:
- 10.4238/2015.August.19.17
Identification of androgenic gland microRNA and their target genes to discover sex-related microRNA in the oriental river prawn, Macrobrachium nipponense
Authors: S.B. Jin, H.T. Fu, S.F. Jiang, Y.W. Xiong, H. Qiao, W.Y. Zhang, Y.S. Gong and Y. Wu
The oriental river prawn, Macrobrachium nipponense, is an important aquaculture species in China. The androgenic gland produces hormones that play crucial roles in the differentiation of crustaceans to the male sex. MicroRNA (miRNA) post-transcriptionally regulates many protein-coding genes, influencing important biological and metabolic processes. Howeve.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.27
- DOI:
- 10.4238/2015.December.23.27
Effect of Bifidobacterium on the mRNA expression levels of TRAF6, GSK-3�², and microRNA-146a in LPS-stimulated rat intestinal epithelial cells
Authors: W. Zhou, Y. Yuan, J. Li, W.M. Yuan, L.G. Huang and S.W. Zheng
We investigated the effect of inactivated Bifidobacterium on the mRNA expression of TRAF6, GSK-3β, and microRNA-146a in lipopolysaccharide (LPS)-stimulated rat small intestinal epithelial cells (IEC-6s). IEC-6s were randomly divided into an LPS group, a culture supernatant group, and an inactivated bacteria group. After stimulation with LPS for 5 h, .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.11
- DOI:
- 10.4238/2015.August.21.11