Migration
Effect of curcumin on the proliferation, apoptosis, migration, and invasion of human melanoma A375 cells
Authors: Y.P. Zhang, Y.Q. Li, Y.T. Lv and J.M. Wang
Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentratio.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.9
- DOI:
- 10.4238/2015.February.6.9
Expression of PAPPA2 in human fetomaternal interface and involvement in trophoblast invasion and migration
Authors: H.Y. Wang, Z. Zhang and S. Yu
Pregnancy-associated plasma protein-A 2 (PAPPA2) is a placental-enriched gene that is important for normal human placentation and defects in the gene can cause complications in pregnancy. Yet the exact expression pattern and role of PAPPA2 in the human fetomaternal interface are not clear. In this study, in situ hybridization (ISH) and immunohistochemistr.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038075
- DOI:
- 10.4238/gmr.15038075
Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an â??eye open at birthâ? phenotype
Authors: L.C. Wu, C. Liu, M.R. Jiang ,Y.M. Jiang, Q.H. Wang, Z.Y. Lu, S.J. Wang, W.L. Yang and Y.X. Shao
Development of the eyelid requires coordination of the cellular processes involved in proliferation, cell size alteration, migration, and cell death. C57BL/6J-corneal opacity (B6-Co) mice are mutant mice generated by the administration of N-ethyl-N-nitrosourea (100 mg/kg). They exhibit the eyelids open at birth phenotype, abnormal round cell shape from ti.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15036741
- DOI:
- 10.4238/gmr.15036741
Targeting effect of microRNA on CD133 and its impact analysis on proliferation and invasion of glioma cells
Authors: C. Zhao, Z.G. Ma, S.L. Mou, Y.X. Yang, Y.H. Zhang, W.C. Yao
MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the .. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019281
- DOI:
- 10.4238/gmr16019281
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma
Authors: Z.Z. Cai, L.B. Xu, J.L. Cai, J.S. Wang, B. Zhou and H. Hu
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pancreatic tissue samples (P = 0.007.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.31
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.31
Sodium valproate inhibits MDA-MB-231 breast cancer cell migration by upregulating NM23H1 expression
Authors: G.-F. Li, T.-L. Qian, G.-S. Li, C.-X. Yang, M. Qin, J. Huang, M. Sun and Y.-Q. Han
Breast cancer is a common cancer in women, with a highly variable course, from inoffensive to lethal. To find a more effective strategy for its treatment, sodium valproate has been tested as an anti-cancer drug; it is the only clinically available histone deacetylase inhibitor. However, data about the effects of sodium valproa.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.13.1
- DOI:
- http://dx.doi.org/10.4238/2012.January.13.1
Overexpression of the growth arrest-specific homeobox gene Gax inhibits proliferation, migration, cell cycle progression, and apoptosis in serum-induced vascular smooth muscle cells
Authors: H. Zheng, S. Xue, Z.L. Hu, J.G. Shan and W.G. Yang
The Gax gene has been implicated in a variety of cell-developmental and biological processes, and aberrant Gax expression is linked to many diseases. In this study, to provide important insights for Gax-based gene therapy in vein graft restenosis and its anti-restenotic mechanism, we used rabbit vascular smooth muscle cells (V.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.March.24.4
- DOI:
- 10.4238/2014.March.24.4
Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis
Authors: Y.L. Wang, W.G. Gong and Q.L. Yuan
Thyroid cancer is the most common type of endocrine tumor. MicroRNAs (miRNAs) play a critical role in a variety of diseases, especially cancer occurrence and progression. However, the specific mechanism by which miRNAs trigger disease states has not been fully elucidated. This study aims to investigate the role of miR-27a in t.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15049070
- DOI:
- 10.4238/gmr15049070
Inverted migration of rare whisker sheatfish in Nong-Han Lake, northeastern Thailand: Implications for conservation
Authors: P. Phongkaew, U. Arunyawat, A. Swatdipong and V. Hongtrakul
Nong-Han Lake, Thailand, sustains the whisker sheatfish (Micronema bleekeri Günther, 1864), which is a rare species of freshwater catfish. Wild-caught whisker sheatfish has been intensively harvested to meet market demand; yet, genetic information about this species remains unknown. To assist with the in situ.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.12.16
- DOI:
- 10.4238/2014.September.12.16
Genetic structure of Aedes aegypti populations determined using pairwise comparisons
Authors: T. de F. Patarro, M.M. Guirado, L.M. Ravazzi and H.E.M. de C. Bicudo
The biological characteristics of Aedes aegypti (Diptera, Culicidae), which is a vector of dengue and yellow fever, make this organism a good model for studying population structure and the events that may influence it under the effect of human activity. We assessed the genetic variability of five A. aegypti populations using RAPD-PCR technique and six pr.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.9
- DOI:
- 10.4238/2013.September.19.9