Migration
miR-133 inhibits pituitary tumor cell migration and invasion via down-regulating FOXC1 expression
Authors: D.S. Wang, H.Q. Zhang, B. Zhang, Z.B. Yuan, Z.K. Yu, T. Yang, S.Q. Zhang, Y. Liu and X.X. Jia
Many studies have shown that microRNA (miR)-133 functions as a tumor suppressor in a variety of metastatic cancers, including breast cancer, gastric cancer, and liver fibrosis. However, the influence of miR-133 on pituitary tumor malignancy has not yet been reported. The purpose of this study was to explore the role of miR-133.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017453
- DOI:
- 10.4238/gmr.15017453
Pivotal role of microRNA-9 in osteosarcoma tumorigenesis and tumor progression
Authors: X.J. Qi, J.F. Wang, G.D. Wang, Q. Xu and H.L. Sun
MicroRNA-9 (miR-9) has a well-established role in various tumors; the clinical significance and potential mechanism of miR-9 in human osteosarcoma (OS) has not been elucidated. The aim of this study was to investigate the mechanism and role of miR-9 expression in osteosarcoma cells. miR-9 expression in the OS cell line MG-63 and OS tissues was compared to.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017318
- DOI:
- 10.4238/gmr.15017318
Role of adiponectin in adipose tissue wound healing
Authors: C.E. Jin, L. Xiao, Z.H. Ge, X.B. Zhan and H.X. Zhou
The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.11
- DOI:
- 10.4238/2015.August.3.11
Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells
Authors: H.CH. Li, Y.X. Zhang, Y. Liu and Q.SH. Wang
We investigated the effect of the IL-17 monoclonal antibody Secukinumab combined with IL-35 in the blockade of the Notch signaling pathway on the invasive capability of hepatoma cells. We examined the effects of IL-17 antibody or IL-35 treatment alone or in combination on cell invasion and migration capabilities with Transwell.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028174
- DOI:
- 10.4238/gmr.15028174