Mitochondria
Application of 16S rRNA, cytochrome b and control region sequences for understanding the phylogenetic relationships in Oryx species
Authors: H.A. Khan, I.A. Arif, A.A. Al Homaidan and A.H. Al Farhan
The present study reports the application of mitochondrial markers for the molecular phylogeny of Oryx species, including the Arabian oryx (AO), scimitar-horned oryx (SHO) and plains oryx (PO), using the Addax as an outgroup. Sequences of three molecular markers, 16S rRNA, cytochrome b and a control region, for the above four taxa were aligned and the top.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr514
- DOI:
- 10.4238/vol7-4gmr514
Mitochondrial DNA haplogroups and somatic mutations are associated with lung cancer in patients from Southwest China
Authors: Y. Fang, H.Y. Yang, Y.H. Shi, J.H. Cui, L.Y. Li, Y.C. Xu and J.L. Shao
Mitochondrial DNA mutations play crucial roles in the pathogenesis and progression of human malignancies. Therefore, to determine whether maternal background or mitochondrial DNA somatic mutations were essential cofactorsin the lung cancer of Chinese patients as well, the complete mitochondrial DNA displacement loop of the primary cancerous, matched para-.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.12.6
- DOI:
- 10.4238/2015.May.12.6
Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway
Authors: Y.B. Ji, G.S. Xin, Z.Y. Qu, X. Zou and M. Yu
This study investigated the nature and mechanism of juglone-induced apoptosis in the human breast cancer cell line MCF-7. The inhibitory effect of juglone on MCF-7 cell growth was evaluated by the dimethylthiazol tetrazolium assay. Morphological apoptotic changes were characterized using an inverted microscope, Hoechst 33258 fluorescence staining, and Gie.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038785
- DOI:
- 10.4238/gmr.15038785
Complete mitochondrial genome sequence of Cheirotonus jansoni (Coleoptera: Scarabaeidae)
Authors: L.L. Shao, D.Y. Huang, X.Y. Sun, J.S. Hao, C.H. Cheng, W. Zhang and Q. Yang
We sequenced the complete mitochondrial genome (mitogenome) of Cheirotonus jansoni (Coleoptera: Scarabaeidae), an endangered insect species from Southeast Asia. This long legged scarab is widely collected and reared for sale, although it is rare and protected in the wild. The circular genome is 17,249 bp long and contains a ty.. Read More»
- Genet. Mol. Res. 13(1):
- 2014.February.20.6
- DOI:
- 10.4238/2014.February.20.6
Expression profiles of genes associated with mitochondria-mediated apoptosis and their roles in liver regeneration
Authors: X.K. Xing, M.H. Li, Z.W. Guo and C.S. Xu
Mitochondria are closely associated with cell survival, and it is of interest to determine whether apoptosis pathways, which are mediated by mitochondria, are involved in liver regeneration (LR). To identify the mechanisms underlying mitochondria-mediated apoptosis during rat LR, we used the Rat Genome 230 2.0 Array to investigate changes in gene expressi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038101
- DOI:
- 10.4238/gmr.15038101
Molecular phylogenetics of the white-lipped peccary (Tayassu pecari) did not confirm morphological subspecies in northwestern South America
Authors: M. Ruiz-GarcÃ?Âa, M. Pinedo-Castro, K. Luengas-Villamil, C. VergaraJ.A. Rodriguez and J.M. Shostell
We sequenced the mitochondrial DNA (mtDNA) control region of 59 peccaries (44 white-lipped peccaries, Tayassu pecari, and 15 collared peccaries, Pecari tajacu). We also genotyped 3 DNA microsatellites from 78 white-lipped peccaries representing the 4 putative morphological subspecies (i.e., spiradens, aequatoris, pecari, and albirostris) present in northw.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.6
- DOI:
- 10.4238/2015.May.22.6
Effect of melatonin on oncosis of myocardial cells in the myocardial ischemia/reperfusion injury rat and the role of the mitochondrial permeability transition pore
Authors: L.F. Liu, Z.H. Qian, Q. Qin, M. Shi, H. Zhang, X.M. Tao and W.P. Zhu
We aimed to evaluate the effect of melatonin on myocardial cell oncosis in the myocardial ischemia/reperfusion injury rat, and the role of the mitochondrial permeability transition pore (MPTP) therein. Sprague Dawley rats (N = 60) were randomly divided into five groups of 12 rats each: control, ischemia/reperfusion (I/R), melatonin treatment (MT), melaton.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.3.24
- DOI:
- 10.4238/2015.July.3.24
Quantitative changes in mitochondrial DNA copy number in various tissues of pigs during growth
Authors: Y.M. Xie, L. Jin, X.J. Chen, M.N. He, Y. Wang, R. Liu, M.Z. Li and X.W. Li
Mitochondrial DNA (mtDNA) content is dependent on the energy requirements of tissues. To date, no comprehensive study has been conducted to examine mtDNA copy number variations in pigs. In the current study, quantitative polymerase chain reaction was performed to quantify the mtDNA copy number in 15 pig tissue types at 5 growth stages from embryo to adult.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.6.12
- DOI:
- 10.4238/2015.March.6.12
Sex-biased gene flow in African Americans but not in American Caucasians
Authors: Goncalves VF, Prosdocimi F, Santos LS, Ortega JM and Pena SDJ
We have previously shown evidence of strong sex-biased genetic blending in the founding and ongoing history of the Brazilian population, with the African and Amerindian contribution being highest from maternal lineages (as measured by mitochondrial DNA) and the European contribution foremost from paternal lineages (estimated f.. Read More»
- Genet. Mol. Res. 6(2):
Phylogeny of major lineages of galliform birds (Aves: Galliformes) based on complete mitochondrial genomes
Authors: X.-Z. Kan, J.-K. Yang, X.-F. Li, L. Chen1, Z.-P. Lei, M. Wang, C.-J. Qian, H. Gao and Z.-Y. Yang
Complete mitochondrial DNA sequences have been used successfully to estimate phylogenetic relationships among animal taxa, and for studies of population genetics and molecular evolution. We made phylogenetic analyses of 22 species of Galliformes, with two species of Anseriformes as outgroups, using maximum likelihood (ML), max.. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr898
- DOI:
- 10.4238/vol9-3gmr898