Multiple Sclerosis
Investigation of the role of apoptosis, necroptosis and DNA damage signaling pathways in multiple sclerosis
Authors: Romina Dastmalchi, Arezou Sayad, Mir Davood Omrani, Soudeh Ghafouri-Fard, Shahram Arsang-Jang, Mehrdokht Mazdeh, Mohammad Taheri*
Multiple sclerosis (MS) as the most common autoimmune disorder in the central nervous system is a major health problem. MS is a complex disease with multiple environmental and genetic factors participating in it. In the present study, we evaluated the expression of 3 genes named BCL2, CASP2 and CASP8 in peripheral blood of 50 MS patients and 50 healthy co.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039937
- DOI:
- http://dx.doi.org/10.4238/gmr16039937
Polymorphism in the third intron of the interferon-�³ gene is associated with susceptibility to multiple sclerosis
Authors: X.L. Wang, F.R. Meng, X. Wang, S.H. Wang and L. Guo
The present study aims to examine the relationship between polymorphisms in the third intron of the IFN-γ gene and their influence on susceptibility to multiple sclerosis. A population-based case-control study was used for this purpose. Multiple sclerosis patients and healthy controls were interviewed. Genetic polymorphi.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16017538
- DOI:
- 10.4238/gmr16017538
Mitochondrial and nuclear genes as the cause of complex I deficiency
Authors: A.R. Rezaee, A. Azadi, M. Houshmand, F. Mahmoodi, Z. Purpak, S. Safaei, P. Karimi, M. Ghabaee and M.A. Sahraian
Multiple sclerosis (MS) is an immunological inflammatory disease of the central nervous system. The pathogenesis of MS is incompletely understood, but various studies have suggested that mitochondrial dysfunction is associated with the disease. Mitochondria are among the main cellular sources of reactive oxygen and nitrogen species, and they play a pivota.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.12.1
- DOI:
- 10.4238/2013.September.12.1