Obesity
Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet
Authors: Khadeejah Mesaid Al-Solami, Zainab Al-refaie, Hossam Awad, Mahmood Rasool
Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study.. Read More»
- Genet. Mol. Res. 18(1):
Roles of beta2-adrenergic receptor gene polymorphisms in a Turkish population with obstructive sleep apnea syndrome or obesity
Authors: �?°. G�?¶k1, �?°. �?�?elebi2, N. H�?¼seyino�?�?lu3 and C. �?�?zic1
We determined the distribution of the Arg16Gly and Gln27Glu polymorphisms of the beta-2 adrenergic receptor gene (ADRB2) in patients with obstructive sleep apnea syndrome as well as a control group in Northeastern Turkey. A total of 52 patients diagnosed with obstructive sleep apnea in a sleep laboratory and 78 control subjects were examined. Peripheral b.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.27
- DOI:
- 10.4238/2014.October.20.27
Association of the tumor necrosis factor-alpha -308G>A polymorphism with breast cancer in Mexican women
Authors: L. G�?³mez Flores-Ramos1,2, A. Escoto-De Dios1, A.M. Puebla-P�?©rez3, L.E. Figuera-Villanueva4, A. Ramos-Silva1,5, R. Ram�?rez-Pati�?±o1,2, J.I. Delgado-Saucedo3, E. Salas-Gonz�?¡lez6, G.M. Z�?º�?±iga-Gonz�?¡lez7, A. Alonzo-Rojo1,2, I. Guti�?©rrez-Hurtado1,2 and M.P. Gallegos-Arreola1
The tumor necrosis factor-alpha (TNF-α) gene plays an important role in cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, insulin resistance, and endothelial function. Polymorphisms of TNF-α have been associated with cancer. We examined the role of the -308G>A polymorphism in this gene by comparing the genotypes.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.17
- DOI:
- 10.4238/2013.November.18.17
Relationship between serum creatinine and obesity in children in Xinjiang, China
Authors: X.-M. Li, Y.-T. Ma, X. Xie, Y.-N. Yang, X.-M. Li and Y.-Y. Zheng
This study was designed to analyze the relationship between serum creatinine and body mass index in children in Xinjiang, China. We used a stratified sampling method to select 5222 children aged 6-17 years in 3 areas in Xinjiang and then measured serum creatinine with an enzymatic method. Our analysis showed that the mean seru.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.13
- DOI:
- 10.4238/2014.April.3.13
A family-based association study identified CYP17 as a candidate gene for obesity susceptibility in Caucasians
Authors: H. Yan, Y. Guo, T.-L. Yang, L.-J. Zhao and H.-W. Deng
The cytochrome P450c17α gene (CYP17) encodes a key biosynthesis enzyme of estrogen, which is critical in regulating adipogenesis and adipocyte development in humans. We therefore hypothesized that CYP17 is a candidate gene for predicting obesity. In order to test this hypothesis, we performed a family-based association t.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.22.1
- DOI:
- 10.4238/2012.May.22.1
Expression profiling based on coexpressed modules in obese prepubertal children
Authors: J.F. Zhang G.Y. Yao Y.H. Wu
The aim of this study was to identify related genes and the underlying molecular mechanisms in obese patients who show a series of clinical and metabolic abnormalities known as metabolic syndrome. We identified expression profiles through a coexpression network. In addition, a similarity matrix and expression modules were constructed based on domain and p.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.31.5
- DOI:
- 10.4238/2012.August.31.5
Microdeletions in 16p11.2 and 13q31.3 associated with developmental delay and generalized overgrowth
Authors: A.M. George J. Taylor D.R. Love
Chromosome microarray analysis of patients with developmental delay has provided evidence of small deletions or duplications associated with this clinical phenotype. In this context, a 7.1- to 8.7-Mb interstitial deletion of chromosome 16 is well documented, but within this interval a rare 200-kb deletion has recently been defined that appears to be assoc.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.3.1
- DOI:
- 10.4238/2012.September.3.1
Methylation profile of SNRPN gene and its correlation with weight and chronological age
Authors: N.V. Carobin, F.V.M. Rubatino, M.L. Freitas, V.T. de Oliveira, R.X. Pietra, A.A. Bosco and F.S. Jehee
Genomic imprinting is an important epigenetic phenomenon, wherein genes or gene clusters are marked by DNA methylation during gametogenesis. This plays a major role in several functions of normal cells, including cell differentiation, X chromosome inactivation, and the maintenance of chromatin structure, in mammalian development. The aim of this study was.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.41
- DOI:
- 10.4238/2015.October.28.41
Correlation analysis of serum obestatin expression with insulin resistance in childhood obesity
Authors: M.Y. Zhang, F. Li and J.P. Wang
Childhood obesity is a serious public health concern condition, as excess body fat can negatively affect a child's health. Obestatin is a hormone that regulates body weight by suppressing appetite and reducing food intake; fasting obestatin level is negatively correlated with basal insulin level. This study aims to investigate.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029210
- DOI:
- 10.4238/gmr16029210
Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays
Authors: Y.D. Apalasamy , F.M. Moy, S. Rampal, A. Bulgiba and Z. Mohamed
A genome-wide association study showed that the tagging single nucleotide polymorphism (SNP) rs7566605 in the insulin-induced gene 2 (INSIG2) was associated with obesity. Attempts to replicate this result in different populations have produced inconsistent findings. We aimed to study the association between the rs7566.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.July.4.4
- DOI:
- 10.4238/2014.July.4.4