Obesity
TNF-�± G-308A polymorphism is associated with insulin resistance: a meta-analysis
Authors: H.G. Wang, J. Yang, H. Han, F. Xu, Y. Bian, H. Zhang and J.L. Wang
Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conflicting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE an.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.26.11
- DOI:
- 10.4238/2015.January.26.11
LEPR p.Q223R, �²3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects
Authors: Duarte SFP, Francischetti EA, Genelhu VA, Cabello PH and Pimentel MMG
Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complicat.. Read More»
- Genet. Mol. Res. 6(4):
Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis
Authors: Y. Liu, G. Wu, L. Han, K. Zhao, Y. Qu, A. Xu and Q. Huang
Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 43.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.February.6.19
- DOI:
- 10.4238/2015.February.6.19
�²3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects
Authors: V.A. Genelhu, E.A. Francischetti, S.F.P. Duarte, B.M.J. Celoria, R.C. Oliveira, P.H. Cabello and M.M.G. Pimentel
We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower .. Read More»
- Genet. Mol. Res. 9(3):
- vol9-3gmr819
- DOI:
- 10.4238/vol9-3gmr819
Prevalence of mutations in LEP, LEPR, and MC4R genes in individuals with severe obesity
Authors: B. Paolini, P.E. Maltese, I. Del Ciondolo, D. Tavian, S. Missaglia, C. Ciuoli, M. Zuntini, S. Cecchin, M. Bertelli and G. Pompucci
Obesity is a major public health concern; despite evidence of high heritability, the genetic causes of obesity remain unclear. In this study, we assessed the presence of mutations in three genes involved in the hypothalamic leptin-melanocortin regulation pathway (leptin, LEP; leptin receptor, LEPR; and melanocortin-4 receptor, MC4R), which is important fo.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038718
- DOI:
- 10.4238/gmr.15038718
Associations between genetic variants and the severity of metabolic syndrome in subjects with type 2 diabetes
Authors: Y.L. Chen, D. Pei, Y.J. Hung, C.H. Lee, F.C. Hsiao, C.Z. Wu,J.D. Lin, C.H. Hsu, J.B. Chang and C.H. Hsieh
Metabolic syndrome (MetS) includes obesity, dyslipidemia, elevated blood pressure, and dysglycemia. Subjects with type 2 diabetes (T2D) exhibit features of MetS. The etiology of MetS is complex, involving both environmental and genetic factors. In this study, we examined the role of specific candidate genetic variants on the severity of MetS in T2D subjec.. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.10
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.10
Apolipoprotein E polymorphism in elderly Japanese-Brazilian immigrants does not explain the reduced cardiovascular risk factor incidence
Authors: N. Terra, Y. Moriguchi, L. Bittencourt, R.S. Trois, J.E.C. Piccoli and I.B.M. Cruz
Study of immigrant populations may contribute to a better understanding of the epidemiology of diseases associated with the aging process. We examined the prevalence of cardiovascular risk factors, including apolipoprotein E (ApoE) polymorphism, in elderly subjects who were born in Japan, migrated to South Brazil and have live.. Read More»
- Genet. Mol. Res. 10(3):
Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease
Authors: A.I. Guney, D. Ergec, D. Kirac, H. Ozturhan, M. Caner, G. Koc, C. Kaspar, K. Ulucan and M. Agirbasli
Coronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk fa.. Read More»
- Genet. Mol. Res. 12(4):
- 2013
- DOI:
- 10.4238/2013
A novel missense mutation T101N in the melanocortin-4 receptor gene associated with obesity
Authors: S. Buchbinder, U. B�¤rtsch, M. M�¼ller, M. Zorn, P.P. Nawroth and T. Schilling
Mutations in the melanocortin-4 receptor (MC4R) are associated with severe obesity, independent of their effect on cortisol or thyroid-stimulating hormone levels. We examined a morbidly obese male (BMI = 62 kg/m2) with a binge-eating disorder and eight family members for mutations in the MC4R gene and potential differences in .. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2gmr948
- DOI:
- 10.4238/vol10-2gmr948
Association of serum adipose triglyceride lipase levels with obesity and diabetes
Authors: L. Yang, S.J. Chen, G.Y. Yuan, L.B. Zhou, D. Wang, X.Z. Wang and J.J. Chen
The aim of this study was to detect the serum adipose triglyceride lipase (ATGL) levels in obesity and newly diagnosed type 2 diabetes patients, and to explore the association between ATGL with glucose and lipid metabolism. We enrolled 66 patients with type 2 diabetes and 48 patients with normal glucose regulation, who were di.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.18
- DOI:
- 10.4238/2014.August.28.18