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Obesity

Human Genetics   Research Article

Lack of effect of maternal body mass index on anthropometric characteristics of newborns in twin gestations

Authors: Gloria M.D.D. Colletto and Concei�?§�?£o A.M. Segre

We examined the correlation between maternal prepregnancy body mass index (BMI) and newborn weight, length, BMI, and gestational order, in singleton and twin births. The sample comprised 381 mothers of multiple babies (562 twins), and 7979 singleton pregnancies, used as controls. The Mann-Whitney non-parametric test was used t.. Read More»

Genet. Mol. Res. 4(1):
Microbial Genetics   Research Article

Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome

Authors: V.R.A. Vargas, S.L. Bonatto, F.E. Macagnan, A.M.P. Feoli, C.S. Alho, N.D.V. Santos and V.M. Schmitt

We evaluated the response of individuals with metabolic syndrome to lifestyle modification intervention and examined the influence of the 48867A>C (Asp358Ala) IL6R (rs2228145) polymorphism on this response. Participants were randomly divided into two groups: NI, nutritional intervention; NIE, nutritional intervention and exercise practice. Intervention.. Read More»

Genet. Mol. Res. 12(3):
2013.February.28.8
DOI:
10.4238/2013.February.28.8
Animal Genetics   Research Article

Association between FTO polymorphism in exon 3 with carcass and meat quality traits in crossbred ducks

Authors: W. Gan, Q. Song, N.N. Zhang, X.P. Xiong, D.M.C. Wang and L. Li

The fat mass and obesity-associated gene (FTO) is an excellent candidate gene that affects energy metabolism. Single nucleotide polymorphisms (SNPs) in FTO are associated with carcass and meat quality traits in pigs, cattle, and rabbits. The aim of this study was to investigate the association between novel SNPs in the FTO coding region and carcass and me.. Read More»

Genet. Mol. Res. 14(2):
2015.June.18.14
DOI:
10.4238/2015.June.18.14
Microbial Genetics   Research Article

Association between rs155971 in the PCSK1 gene and the lipid profile of obese Thai children: a family-based study

Authors: S. Kulanuwat, J. Santiprabhob, B. Phonrat, C. Limwongse, A. Tungtrongchitr, N. Chongviriyaphan and R. Tungtrongchitr

Genetic variants of the POMC and PCSK1 genes cause severe obesity among patients in the early stages of childhood. This family-based study analyzed the links between single nucleotide polymorphisms (SNPs) in either the POMC or PCSK1 genes and obesity, as well as obesity-related traits among obese Thai children and their families. The variants rs1042571 an.. Read More»

Genet. Mol. Res. 14(3):
2015.August.7.23
DOI:
10.4238/2015.August.7.23
Microbial Genetics   Research Article

Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine

Authors: D.F. Jiang, X.G. Zhang, H.L. Yang and C. Sun

Evodiamine is the main active alkali of Wu Zhuyu, a widely distributed Chinese herb. It plays an important role in the regulation of body fat deposition. In this study, we aimed to investigate the effect of evodiamine administration on the expression of genes involved in lipid metabolism in the liver and adipose tissue. Fasted mice were subcutaneously inj.. Read More»

Genet. Mol. Res. 12(2):
2013.January.4.13
DOI:
10.4238/2013.January.4.13
Human Genetics   Research Article

Prader-Willi-like phenotypes: a systematic review of their chromosomal abnormalities

Authors: C.F. Rocha and C.L.A. Paiva

Prader-Willi syndrome (PWS) is caused by the lack of expression of genes located on paternal chromosome 15q11-q13. This lack of gene expression may be due to a deletion in this chromosomal segment, to maternal uniparental disomy of chromosome 15, or to a defect in the imprinting center on 15q11-q13. PWS is characterized by hyp.. Read More»

Genet. Mol. Res. 13(1):
2014.March.31.9
DOI:
10.4238/2014.March.31.9
Human Genetics   Research Article

Genetic variant screening of MC3R and MC4R genes in early-onset obese children and their relatives among a Thai population: family-based study

Authors: S. Wannaiampikul, B. Phonrat, A. Tungtrongchitr, C. Limwongse, N. Chongviriyaphan, J. Santiprabhob and R. Tungtrongchitr

MC3R (melanocortin-3 receptor) and MC4R (melanocortin-4 receptor) play important roles in energy homeostasis. Severe early-onset obesity, known as monogenic obesity when it is the consequence of a mutation in a single-gene product, may result when energy homeostasis is disrupted. The purpose of our study was to screen for variations of the MC3R and MC4R g.. Read More»

Genet. Mol. Res. 14(4):
2015.December.22.35
DOI:
10.4238/2015.December.22.35
Microbial Genetics   Research Article

Can Spirulina maxima reduce the mutagenic potential of sibutramine?

Authors: R.P. Araldi, N.P. Santos, T.B. Mendes, L.B. Carvalho, E.T. Ito, P.L. de-S�?¡-J�?ºnior and EB Souza

The worldwide obesity pandemic requires the use of anti-obesity drugs. Sibutramine is an anti-obesity drug that has been used worldwide but is indiscriminately consumed in Brazil. Several studies have demonstrated that sibutramine promotes weight loss and weight maintenance, but several side effects have been associated with its systematic consumption. Fo.. Read More»

Genet. Mol. Res. 14(4):
2015.December.23.33
DOI:
10.4238/2015.December.23.33
Human Genetics   Research Article

Exome sequencing in Thai patients with familial obesity

Authors: S. Kaewsutthi, J. Santiprabhob, B. Phonrat, A. Tungtrongchitr,P. Lertrit and R. Tungtrongchitr

Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of .. Read More»

Genet. Mol. Res. 15(2):