Ovarian Cancer
Integrative omics of ovarian cancer
Authors: Yanisa Rattanapan and Takol Chareonsirisuthigul
Omics such as genomics, transcriptomics, proteomics, and metabolomics are gathering the study of entire characterization and molecular biology processes of organisms. The advancement in studying omics has become useful and widely applied to many human diseases. For ovarian cancer, pathogenic mechanisms at molecular levels resulting in the development of c.. Read More»
- Genet. Mol. Res. 18(4):
Steroid metabolism gene polymorphisms and their implications on breast and ovarian cancer prognosis
Authors: E.V.W. dos Santos, L.N.R. Alves and I.D. Louro
A role for estrogen in the etiology of breast and ovarian cancers has been suggested; therefore, genetic polymorphisms in steroid metabolism genes could be involved in the carcinogenesis of these tumors. We have aimed to investigate the role of GSTP1 and CYP17 polymorphisms and their correlation with MSI (microsatellite instab.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039691
- DOI:
- 10.4238/gmr16039691
Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice
Authors: G.H. Zhu, S.T. Wang, M.Z. Yao, J.H. Cai, C.Y. Chen, Z.X. Yang, L. Hong and S.Y. Yang
The objective of this study was to explore the feasibility and methods of screening the residual normal ovarian tissue adjacent to orthotopic ovarian carcinomas in nude mice. Human epithelial ovarian cancer cells (OVCAR3) were subcutaneously implanted for a tumor source and ovarian orthotopic transplantation. The cancer tissue.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.16.6
- DOI:
- 10.4238/2014.April.16.6
Tumor-associated fibroblast-conditioned medium promotes tumor cell proliferation and angiogenesis
Authors: L.N. Xu, B.N. Xu, J. Cai, J.B. Yang, N. Lin
This study aimed to explore how tumor-associated fibroblasts (TAFs) promote the proliferation and angiogenesis of tumor cells via the paracrine mechanism in vitro. Conditioned media (CM) of ovarian TAFs and normal fibroblasts (NFs) were collected. Ovarian cancer cells (OCCs) were treated with 2 mL TAFs-CM and NFs-CM in experim.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.14
- DOI:
- 10.4238/2013.November.22.14
Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells
Authors: H. Yan, J.Y. Xia and F.Z. Feng
The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019411
- DOI:
- 10.4238/gmr16019411
Arg188His polymorphism in the XRCC2 gene and the risk of ovarian cancer: a meta-analysis
Authors: M. Zhai, Y. Wang and M.F. Jiang
Numerous studies have evaluated the association between the Arg188His polymorphism of the X-ray repair cross-complementing group 2 (XRCC2) gene and ovarian cancer risk. However, the specific association is still controversial. This meta-analysis was therefore designed to clarify these controversies. Relevant case-control studies were enrolled in the meta-.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.19
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.19
Cumulative methylation alternations of gene promoters and protein markers for diagnosis of epithelial ovarian cancer
Authors: B.L. Xing, T. Li, Z.H. Tang, L. Jiao, S.M. Ge, X. Qiang and J. OuYang
DNA methylation plays an important role in carcinogenesis and cancer development. In this study, we examined gene methylation in epithelial ovarian cancer (EOC) using cationic conjugated polymer (CCP)-based fluorescence resonance energy transfer (FRET) to evaluate the application of cumulative methylation alternations of genes associated with cancer antig.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.11
- DOI:
- 10.4238/2015.May.4.11
Gene expression profiling of epithelial ovarian cancer reveals key genes and pathways associated with chemotherapy resistance
Authors: M. Zhang and S.C. Luo
The aim of this study is to analyze gene expression data to identify key genes and pathways associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer (EOC) and to improve clinical treatment strategies. The gene expression data set was downloaded from Gene Expression Omnibus and included 12 chemotherapy-resistant EOC samples an.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017496
- DOI:
- 10.4238/gmr.15017496
Prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis
Authors: Y.Y. Shi and H. Jiang
This meta-analysis study aimed to investigate the correlation between CD44-positive cancer stem cells (CSCs) and clinicopathological features and its effect on the survival of ovarian cancer patients. A comprehensive literature search in the electronic databases, including PubMed, EMBASE, and Wanfang (up to December 1, 2015), was conducted. Publications a.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038325
- DOI:
- 10.4238/gmr.15038325
Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro
Authors: Y.J. Tang, Z.L. Sun, W.G. Wu, J. Xing, Y.F. He, D.M. Xin and P. Han
The aim of the present study was to investigate the anti-ovarian cancer effect of the inhibitor of signal transducer and activator of transcription 3 (STAT3), WP1066. Western blot was used to detect the phosphorylation of STAT3 in ovarian cancer cell line SKOV3 and cisplatin-resistant ovarian cancer cell line SKOV3/DDP. MTT and colony-forming assays were .. Read More»
- Genet. Mol. Res. 14(1):
- http://dx.doi.org/2015.March.30.3
- DOI:
- http://dx.doi.org/10.4238/2015.March.30.3