Ovarian Cancer
MTHFR A1298C polymorphism and ovarian cancer risk: a meta-analysis
Authors: X.Y. Shi and Q. Shen
Numerous studies have evaluated the association between the MTHFR A1298C polymorphism and ovarian cancer risk. However, the specific association is still controversial. Therefore, we performed the present meta-analysis. A systematic literature search of PubMed and Embase databases was undertaken in August 2014, and the reference lists of articles were ret.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.8
- DOI:
- 10.4238/2015.July.27.8
Association of the genetic polymorphisms of NFKB1 with susceptibility to ovarian cancer
Authors: L.P. Chen, P.S. Cai and H.B. Liang
Nuclear factor-kB (NF-kB), a transcription factor that is activated by various stimuli, is associated with the pathogenesis of several cancers. One functional polymorphism, -94 insertion/deletion ATTG (rs28362491), in the human NFKB1 gene (one member of the NF-kB gene family) is associated with increased risk of various cancers. However, only one study ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.27.15
- DOI:
- 10.4238/2015.July.27.15
miR-146a and miR-196a2 polymorphisms in ovarian cancer risk
Authors: X.C. Sun, A.C. Zhang, L.L. Tong, K. Wang, X. Wang, Z.Q. Sun and H.Y. Zhang
We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of mi.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038468
- DOI:
- 10.4238/gmr.15038468
Downregulation of microRNA-630 inhibits cell proliferation and invasion and enhances chemosensitivity in human ovarian carcinoma
Authors: Y.T. Zou, J.Y. Gao, H.L. Wang, Y. Wang, H. Wang and P.L. Li
MicroRNAs (miRNAs) are a family of small non-coding RNAs (approximately 21-23 nt long) that can target genes for either degradation of mRNA or inhibition of translation. miRNAs have not been comprehensively studied in human epithelial ovarian carcinoma (EOC). MicroRNA-630 (miR-630) has been frequently observed to be aberrantly expressed in various types o.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.31.25
- DOI:
- 10.4238/2015.July.31.25
Roles of functional NFKB1 and �²-TrCP insertion/deletion polymorphisms in mRNA expression and epithelial ovarian cancer susceptibility
Authors: Z.H. Huo, H.J. Zhong, Y.S. Zhu, B. Xing and H. Tang
Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological cancers. Nuclear factor-kappa B (NF-κB) is involved in carcinogenesis and in the development of EOC. The β-transducin repeat-containing protein (β-TrCP) is a positive regulator of the NF-κB signaling pathway. Recent studies have indicated that the -.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.March.11.6
- DOI:
- 10.4238/2013.March.11.6
Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo
Authors: H. Wu, K. Wang, W. Liu and Q. Hao
Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) overexpression mediates the resistance-revers.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.1
- DOI:
- 10.4238/2015.June.18.1
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer
Authors: W. Pan and H. Liao
The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.8
- DOI:
- 10.4238/2015.December.14.8
Effects of the balance between type 1 and type 2 T helper cells on ovarian cancer
Authors: C.J. Hao, J. Li, P. Liu, X.L. Li, Y.Q. Hu, J.C. Sun and Y. Wei
The balance between type 1 and type 2 T helper cells (the Th1-Th2 balance) is closely correlated with cancer, but the correlation in ovarian cancer remains unconfirmed. We investigated the Th1-Th2 balance for the diagnosis, treatment, and prognostic evaluation of ovarian cancer. Fifty healthy subjects and 50 ovarian cancer pat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027936
- DOI:
- 10.4238/gmr.15027936
Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer
Authors: Q. Xu, Y.Y. Ding, L.X. Song andJ.F. Xu
The aim of this study was to define the genotypes of UGT1A1 and ERCC1 and to examine their relationship with the efficacy and toxicity of a combination therapy of irinotecan and cisplatin in patients with advanced ovarian cancer. The allelic frequencies of the UGT1A1 and ERCC1 variants in a group of 89 patients with advanced ovarian cancer were determined.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.17
- DOI:
- 10.4238/2015.June.29.17