Polymorphism
Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphisms and Risk of Aneurysmal Subarachnoid Hemorrhage: An Updated Meta-Analysis
Authors: N. Manabesh, M. Shubham, K. Amit, S. Rakhee, K. Pradeep
Previously published studies have examined whether the polymorphisms (G894T, 4b/a, and T786C) in the Endothelial Nitric Oxide Synthase (eNOS) gene are associated with risk of Aneurysmal Subarachnoid Hemorrhage (aSAH), have reported conflicting results. Thus, we performed a meta-analysis to examine the potential association between these three single nucle.. Read More»
- Genet. Mol. Res. 19(5):
Synonymous Variant of ACE Gene (rs4343) is Coupled with Early Age at Onset and Diminished Diabetic Duration in South Indian Diabetic Nephropathy Patients
Authors: S. Babi Heera, Umme Najiya Mahwish, Fazul Rahman, Sayeeduddin S, Sree Bhushan Raju , Parveen Jahan
Diabetic nephropathy (T2DN) is a major micro vascular complication associated with type-2 diabetes (T2DM). Abnormally active Renin Angiotensin System pathway is shown to influence the development of T2DN and the inter-individual variation with respect to ACE levels, a key enzyme in this pathway partly dependent on the genetic variants of ACE.. Read More»
- Genet. Mol. Res. 19(5):
Possible association of proinflammatory cytokine IL-19 gene polymorphism with psoriasis
Authors: Wani Aadil, Bashir Ahmad Ganai, Tahseena Akhtar Tarun Narang, Rajinder Kaur
Background: Interleukin (IL-19) a member of the IL-10 family involved in abnormal keratinocyte differentiation and proliferation which is the hall mark of psoriasis. Aim: The aim of this study was to investigate the association between IL-19 gene polymorphism in patients with chronic plaque psoriasis as a factor in the susceptibility and developme.. Read More»
- Genet. Mol. Res. 18(1):
Relationship between melanoma-associated antigen 1 (MAGE-A1) gene polymorphisms and colorectal cancer development
Authors: Mikhlid Almutairi and Abdelhabib Semlali
In the Saudi population, colorectal cancer (CRC) is the first and third most common malignancy among males and females, respectively. The CRC risk is associated with the expression of certain genes, which can be used for prognoses and for finding screening-related biomarkers. One such gene is melanoma-associated antigen 1 (MAGE-A1); however, little is kno.. Read More»
- Genet. Mol. Res. 18(4):
Interleukin-7 receptor gene rs12516866 polymorphism decreases the susceptibility of estrogen receptor negative Saudi women to breast cancer
Authors: Mikhlid Almutairi, Rafa Almeer, Abdullah M Alhadeq and Abdelhabib Semlali
Background: Genetic polymorphisms in IL-7R are associated with the risk of development of multiple diseases, including breast malignancy. At present, no evidence exists for an influence of gene polymorphism of IL-7R on BC susceptibility in Saudi Arabian populations. The aim of the study was therefore to evaluate whether common polymorphisms in the IL-7R g.. Read More»
- Genet. Mol. Res. 17(4):
- http://dx.doi.org/gmr16039935
- DOI:
- http://dx.doi.org/10.4238/gmr16039935
CD40 rs4810485 T>G polymorphism and susceptibility to ankylosing spondylitis in the Latvian population
Authors: J. Zepa, L. Silami�·ele, I. Bulina, V. Lavrentjevs, I. Trapina, J. Klovins, D. Andersone, A. Lejnieks and L. Nikitina-Zake
Ankylosing spondylitis (AS) is a potentially disabling form of a systemic chronic inflammatory arthritis affecting mainly the axial skeleton, with or without extraspinal manifestations. The genetic basis of AS is partly known. Moreover, many autoimmunityrelated genes have pleiotropic effects. Multiple functional polymorphisms .. Read More»
- Genet. Mol. Res. 17(3):
- http://dx.doi.org/gmr18081
- DOI:
- http://dx.doi.org/10.4238/gmr18081
Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis
Authors: T.R. Santos, K.S.F. e Silva, R.C.P.C. Silva, K.K.V.O. Moura, L.A. Guillo, C.L. Ribeiro J�ºnior and I.R. Costa
Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tiss.. Read More»
- Genet. Mol. Res. 17(3):
- http://dx.doi.org/gmr18046
- DOI:
- http://dx.doi.org/10.4238/gmr18046
Interleukin-27�924A/G gene polymorphism is associated with Rheumatoid Arthritis in Egyptian population
Authors: A. Badawy, A.H. Mohamed, A.A. Enein, R. Qasem, E. Rizk, E. El-Masry , S. Abdellatif and M. Balata
Rheumatoid arthritis (RA) is an autoimmune disease with increasing activity of T lymphocytes and abnormal production of inflammatory cytokines. Interleukin-27 (IL-27), a multifunction cytokine with contradictory inflammatory effect. Polymorphism of IL-27 was reported to be predisposed to many inflammatory diseases and autoimmu.. Read More»
- Genet. Mol. Res. 17(2):
- gmr16039915
- DOI:
- 10.4238/gmr16039915
Scientometric analysis: Five years of genetic polymorphisms
Authors: A.M. Barbosa, K.S.F. De Silva, M.H. Lagares, D.A. Rodrigues, J.V.M. Martins, I.R. Da Costa, K.K.V.O. Moura
Scientometrics is a quantitative evaluation of scientific and technological activities. The main objective is to point the number of methodologies used in scientific studies or even the structure of several research centers. This type of metric study belongs to the area of sociology of scientific knowledge. It covers quantitat.. Read More»
- Genet. Mol. Res. 17(2):
- gmr16039913
- DOI:
- 10.4238/gmr16039913
Isolation and characterization of twenty-three microsatellite loci for the black rockfish, Sebastes schlegelii
Authors: F. Wang, H. B. Jiang, C. H. Han, G. P Cui, C. F. Jia, H.T. Ma
Twenty-three polymorphic microsatellite loci were developed from the black rockfish, Sebastes schlegelii, with an enriched partial genomic library by magnetic beads and polymorphism of these loci was assessed in 32 individuals from a wild population. The loci yielded 2-19 alleles per locus, the observed, expected heterozygosit.. Read More»
- Genet. Mol. Res. 17(2):
- gmr16039912
- DOI:
- 10.4238/gmr16039912