Polymorphism
In vitro effects of Ala16Val manganese superoxide dismutase gene polymorphism on human white blood cells exposed to methylmercury
Authors: T.D. Algarve1, F. Barbisan2, E.E. Ribeiro3, M.M.M.F. Duarte4, M.F. M�¢nica-Cattani1, C.P. Mostardeiro2, A.F. Lenz1 and I.B.M. da Cruz1,2,4
Environmental contamination by methylmercury (MeHg) is an enormous public health problem in world regions such as Amazonia. MeHg toxic effects seem to be influenced by environmental and genetic factors. However, few studies have evaluated the genetic influences of MeHg toxicity in humans. Therefore, the aim of this study was to evaluate the genetic influe.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.29.7
- DOI:
- 10.4238/2013.October.29.7
Polymorphism of SREBP1 is associated with beef fatty acid composition in Simmental bulls
Authors: L. Xu*, L.P. Zhang*, Z.R. Yuan, L.P. Guo, M. Zhu, X. Gao, H.J. Gao, J.Y. Li and S.Z. Xu
The sterol regulatory element binding factor 1 gene (SREBP1) plays an important role in the biosynthesis of fatty acids and cholesterol, and in lipid metabolism. The objective of this study was to investigate the effect of genetic polymorphisms of SREBP1 on the fatty acid composition of muscle and carcass traits in Simmental bulls and Snow Dragon black ca.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.7
- DOI:
- 10.4238/2013.November.22.7
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility
Authors: L.P. Ren, Y.S. Xian, D.M. Diao, Y. Chen, Q. Guo and C.X. Dang
BRCA1-interacting protein C-terminal helicase 1 (BRIP1) is a DNA helicase that influences the DNA repair ability and tumor suppressor function of BRCA1. Truncating BRIP1 mutations have been described as cancer susceptibility alleles. To evaluate BRIP1 polymorphisms as risk factors for breast cancer, we performed a detailed analysis of possible single nucl.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.22.6
- DOI:
- 10.4238/2013.November.22.6
Development and characterization of novel microsatellite markers in the rock bream fish Oplegnathus fasciatus
Authors: X.X. Sun, D.D. Xu, B. Lou, S.L. Li, W. Zhan, Y.R. Zhang and J. Xin
The rock bream fish Oplegnathus fasciatus is one of the most popular aquaculture species in China. In the present study, 15 novel polymorphic microsatellite loci were isolated and characterized from a wild population of O. fasciatus from the Zhoushan coast of China. The number of alleles per polymorphic locus ranged from 4 to 9 in a sample of 30 individua.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.10.7
- DOI:
- 10.4238/2013.December.10.7
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis
Authors: G. Lin, J. Zhao, J. Wu, R. Andreevich O, W.-H. Zhang, Y. Zhang and L. Yu
Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. Recent epidemiological studies have investigated the correlation of COMT Val158Met polymorphism with endometrial cancer risk; however, the results are inconsistent. To better.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.10.5
- DOI:
- 10.4238/2013.December.10.5
Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with C-reactive protein in Chinese Han patients with spontaneous basal ganglia hemorrhage
Authors: X.-Q. Dong, Q. Du, W.-H. Yu, Z.-Y. Zhang, Q. Zhu, Z.-H. Che, H. Wang, J. Chen, S.-B. Yang and J.-F. Wen
We examined a possible relationship -420C>G SNP of the resistin gene with plasma resistin and C-reactive protein concentrations in intracerebral hemorrhage. Three hundred and forty-four Chinese Han patients with intracerebral hemorrhage and 344 age- and gender-matched healthy controls were included in our study. Plasma resi.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.19.4
- DOI:
- 10.4238/2012.July.19.4
Association of RGA-SSCP markers with resistance to downy mildew and anthracnose in grapevines
Authors: P.A. Tantasawat, O. Poolsawat, T. Prajongjai, W. Chaowiset and A. Tharapreuksapong
Downy mildew (Plasmopara viticola) and anthracnose (Sphaceloma ampelinum) are two major diseases that severely affect most grapevine (Vitis vinifera) cultivars grown commercially in Thailand. Progress of conventional breeding programs of grapevine for improved resistance to these diseases can be speeded up by selection of mole.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.2.1
- DOI:
- 10.4238/2012.July.2.1
Genetic polymorphisms of the IGF-II gene intron 8 coding region and its association with growth and carcass traits in yak
Authors: Y.F. Zeng, X.Z. Ding, S.R. Cheng and S.J. Yu
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth and is involved in stimulating fetal cell division, differentiation, and metabolic regulation. IGF-II is considered a candidate gene for genetic markers of growth and carcass traits. Therefore, in this study, the associations of single nucleotide polymorphisms (SNPs) in the IGF-II.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.11.11
- DOI:
- 10.4238/2013.December.11.11
Frequencies of -308G/A (TNFA) and -509C/T (TGFB1) polymorphisms in sickle cell anemia patients from Brazil
Authors: L.S. Torres, E. Belini Junior, D.G. Silva, C.L. Lobo, M.A. Ruiz and C.R. Bonini-Domingos
Sickle cell anemia is an affection that causes chronic inflammation, with consequences for vaso-occlusion, oxidative stress and cytokine production. Genetic polymorphisms in markers involved in this process can modulate the inflammatory response, including polymorphisms -308G/A of TNFA (tumor necrosis factor alpha) and -509C/T of TGFB1 (transforming growt.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.16.1
- DOI:
- 10.4238/2013.December.16.1
Polymorphism in PGLYRP-2 gene by PCR-RFLP and its association with somatic cell score and percentage of fat in Chinese Holstein
Authors: H.L. Wang, Z.X. Li, L. Chen, J. Yang, L.J. Wang, H. He, F.B. Niu, Y. Liu, J.Z. Guo and X.L. Liu
Peptidoglycan recognition protein 2 (PGLYRP-2), which belongs to the PGRP family, is the only member that has no direct bactericidal activity but has N-acetylmuramoyl-l-alanine amidase activity. This feature of PGLYRP-2 indicates that it may play an important role in eliminating the pathogen associated molecular pattern (PAMP), such as peptidoglycan (PGN).. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.13.7
- DOI:
- 10.4238/2013.December.13.7