Polymorphism
Heat shock protein 70 polymorphisms in Chinese patients with Graves� disease
Authors: Y.P. Wang, Z. Tang, B.K. Peng,Q. Zhen, S.L. Zhou and X.F. Jin
Graves’ disease (GD) is a common autoimmune disease mainly affecting the thyroid. However, the correlation between the development of GD and HSP70 alleles has not been reported in the Chinese population. Therefore, the aim of this study was to investigate the association between HSP70 polymorphisms and GD in the Chinese population. A total of 153 pa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.25
- DOI:
- 10.4238/2015.December.23.25
Genetic relatedness of artichoke (Cynara scolymus L.) hybrids using random amplified polymorphic DNA (RAPD) fingerprinting
Authors: M.A. Sharaf-Eldin, A. Al-Tamimi, P. Alam, S.F. Elkholy and J.R. Jordan
The artichoke (Cynara scolymus L.) is an important food and medicinal crop that is cultivated in Mediterranean countries. Morphological characteristics, such as head shape and diameter, leaf shape, and bract shape, are mainly affected by environmental conditions. A molecular marker approach was used to analyze the degree of polymorphism between artichoke .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.31
- DOI:
- 10.4238/2015.December.23.31
SLC2A9 and ZNF518B polymorphisms correlate with gout-related metabolic indices in Chinese Tibetan populations
Authors: X.Y. Zhang, T.T. Geng, L.J. Liu, D.Y. Yuan, T. Feng, L.L. Kang, T.B. Jin and C. Chen
Current evidence suggests that heredity and metabolic syndrome contribute to gout progression. SLC2A9 and ZNF518B may play a role in gout progression in different populations, but no studies have focused on the Tibetan Chinese population. In this study, wedetermined whether variations in these 2 genes were correlated with gout-related indices in Chinese-T.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.26
- DOI:
- 10.4238/2015.August.19.26
Aldehyde dehydrogenase 2 (ALDH2) polymorphism gene and coronary artery disease risk: a meta-analysis
Authors: L.L. Zhang, Y.Q. Wang, B. Fu, S.L. Zhao and Y. Kui
We studied the association between aldehyde dehydrogenase 2 (ALDH2) polymorphism and coronary artery disease (CAD) and clarified the mechanisms underlying this association. We searched the ISI, Medline (Ovid), PubMed, CNKI, Wanfang, and Weipu Databases. Statistical analysis was performed using Revman 5.0 and Stata12.0 softwares. A total of 3305 cases and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.38
- DOI:
- 10.4238/2015.December.23.38
APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease
Authors: Y. Sun, R.B. Zhou and D.M. Chen
The aim of this study was to investigate correlations between apolipoprotein A-V (APOA5) -1131T>C and apolipoprotein C-III (APOC3) -455T>C polymorphisms and coronary heart disease (CHD). PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched using combinations of keywords relating to thes.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.9
- DOI:
- 10.4238/2015.December.23.9
Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population
Authors: Q. Chen, X.D. Peng, C.Q. Huang, X.Y. Hu and X.M. Zhang
In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD). This case-control study examined the genotypes of apolipoprotein E (APOE e4) and BMAL1 rs2278749 T/C using restriction fragment length polymorphism and the TaqMan assay, respectively. A total of 296 unrel.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.39
- DOI:
- 10.4238/2015.December.23.39
Mitochondrial tRNA mutations may be infrequent in hepatocellular carcinoma patients
Authors: G. Li, Y.X. Duan, X.B. Zhang and F. Wu
Mitochondrial DNA mutations have been shown to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). In particular, genes encoding mitochondrial tRNA (mt-tRNA) are hotspots for pathogenic mutations associated with HCC. Recently, an increasing number of studies have reported the involvement of such mutatio.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027665
- DOI:
- 10.4238/gmr.15027665
Association of LT�²R gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population
Authors: S.H. Lee, S.K. Kim, K.H. Yoo, J.H. Chung and S.G. Chang
The lymphotoxin-β receptor (LTβR) gene is involved in autoimmune disease and inflammatory disorder development, but the relationship between LTβR and benign prostatic hyperplasia (BPH) is unclear. In total, 222 with BPH were examined for 3 single nucleotide polymorphisms [rs3759333 (-1387C/T), rs3759334 (-1326A/G), and rs2364480 (Ala172Ala).. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.9
- DOI:
- 10.4238/2015.December.28.9
Association of the PPAR�³2 Pro12Ala polymorphism with increased risk of cardiovascular diseases
Authors: Y. Li, J. Zhu and J.Q. Ding
This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of high-quali.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.15
- DOI:
- 10.4238/2015.December.28.15
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil
Authors: M.D. Ara�ºjo, B.N. Borges, S. Rodrigues-Antunes, R.M.R. Burbano and M.L. Harada
The folate metabolic pathway, which is involved in DNA synthesis and methylation, is associated with individual susceptibility to several diseases, including gastric tumors. In this study, we investigated four polymorphisms [thymidylate synthase enhancer region, single nucleotide polymorphism thymidylate synthase 5' (TS5'), TS3' untranslated region, and m.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.6
- DOI:
- 10.4238/2015.August.21.6