Polymorphism
High polymorphism at microsatellite loci in the Chinese donkey
Authors: R.F. Zhang, W.M. Xie, T. Zhang and C.Z. Lei
To reveal the genetic diversity and phylogenetic relationships between Chinese donkey breeds, 415 individuals representing ten breeds were investigated using ten microsatellite markers. The observed number of alleles, mean effective number of alleles (NE), mean expected heterozygosity (HE), and polymorphic information content .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028291
- DOI:
- 10.4238/gmr.15028291
Association between TAP1 gene polymorphisms and alopecia areata in a Korean population
Authors: H.K. Kim, H. Lee, B.L. Lew, W.Y. Sim, Y.O. Kim, S.W. Lee, S. Lee, I.K. Cho, J.T. Kwon and H.J. Kim
The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways. Investigation of polymorphisms identified in these loci has revealed an association with several autoimmune disorders. Alope.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.31
- DOI:
- 10.4238/2015.December.28.31
Association between PAI-1 polymorphisms and plasma PAI-1 level with sepsis in severely burned patients
Authors: Y.F. Chi, J.K. Chai, Y.M. Yu H.M. Luo, Q.X. Zhang and R. Feng
We investigated the association between plasminogen activator inhibitor-1 (PAI-1) polymorphisms and plasma PAI-1 level with sepsis in severely burned patients. A total of 182 patients with burn areas lager than 30% of the body surface area were enrolled in this study. Peripheral blood samples were obtained from 103 patients with sepsis (sepsis group) and .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.15
- DOI:
- 10.4238/2015.August.21.15
Polymorphisms in GJA1 and their association with growth traits in chicken
Authors: M. Shahjahan, R.R. Liu, G.P. Zhao, J.J. Zhang, M.Q. Zheng, Q.H. Li and J. Wen
This study aimed to screen single nucleotide polymorphisms (SNPs) in the chicken gap junction protein alpha 1 (GJA1) gene, and to investigate their association with five growth traits measured in 269 chickens encompassing Chinese indigenous Beijing-You (BJY) and commercial Cobb broiler (CB) populations. Four variants were detected in the chicken GJA1 gene.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.33
- DOI:
- 10.4238/2015.December.28.33
Glutathione S-transferase polymorphisms in varicocele patients: a meta-analysis
Authors: B. Zhu, L. Yin and J.Y. Zhang
The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patien.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.34
- DOI:
- 10.4238/2015.December.28.34
Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma
Authors: Z.H. Cao, H.P. Yin, N. Jiang and B. Yu
We aimed to evaluate the influence of four SNPs in ERCC1 and ERCC2 on the response to cisplatin-based treatment and on clinical outcome in patients with osteosarcoma. We identified 186 patients with osteosarcoma diagnosed between April 2009 and April 2011 who were eligible for inclusion in our study. Genotyping of ERCC1 rs11615, rs3212986, and rs2298881; .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.21
- DOI:
- 10.4238/2015.August.21.21
Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population
Authors: Y. Yang, J.R. Xu, Y.J. Wang and X.M. Li
Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui popula.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.13
- DOI:
- 10.4238/2015.August.21.13
Predictive potential role of glutathione S-transferase polymorphisms in the prognosis of breast cancer
Authors: X. Wang and Z.H. Huang
The current study aimed at evaluating the association between GSTM1 null/present, GSTT1 null/present, and GSTP1 IIe105Val polymorphisms and clinical response to chemotherapy and treatment outcome of breast cancers patients. Genotyping of GSTP1 rs1695, GSTT1 deletion, and GSTM1 deletion was performed by Polymerase Chain Reaction Restriction Fragment Length.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.7
- DOI:
- 10.4238/2015.August.28.7
Investigation of single nucleotide polymorphisms in phosphodiesterase 4D gene in Mongol and Han patients with ischemic stroke in Inner Mongolia
Authors: J.P. Shi, W.D. Chen, J.Q. Zhou, M.M. Xue, F. Xue, H.Z. Li and Z.P. Xu
We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.13
- DOI:
- 10.4238/2015.August.28.13
HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women
Authors: S.M. Li, H. Guo, H.J. Yang, M.Q. Lv and D.X. Zhou
Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. P.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.18
- DOI:
- 10.4238/2015.August.28.18