Polymorphism
Polymorphism of MyoD1 and Myf6 genes and associations with carcass and meat quality traits in beef cattle
Authors: X.H. Du, Q.F. Gan, Z.R. Yuan, X. Gao, L.P. Zhang, H.J. Gao,J.Y. Li and S.Z. Xu1
Myogenic determination factor 1 (MyoD1) and myogenic factor 6 (Myf6) genes belong to the myogenic differentiation (MyoD) gene family, which play key roles in growth and muscle development. The study aimed to investigate the effects of variants in cattle MyoD1 and Myf6 on carcass and meat traits. We screened single nucleotide polymorphisms (SNPs) of both g.. Read More»
- Genet. Mol. Res. 12(4):
- dx.doi.org/2013.December.13.4
- DOI:
- dx.doi.org/10.4238/2013.December.13.4
Genetic polymorphisms of CCND1 and PTEN in progression of esophageal squamous carcinoma
Authors: Y. Jang1, S.A. Lu2, Z.P. Chen3, J. Ma3, C.Q. Xu3, C.Z. Zhang3 and J.J. Wang4
Cyclin D1 (CCND1) plays a significant role in G1-S transition of cell cycle, and phosphatase and a tensin homologue (PTEN) negatively regulate cell cycle through phosphatidylinositol 3-kinase (PI3K)/AKT signaling. CCND1 and PTEN genetic polymorphisms might induce susceptibility to the occurrence of esophageal squamous cell carcinoma (ESCC). Three hundred .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.13.2
- DOI:
- 10.4238/2013.December.13.2
Thirty-four Musa (Musaceae) expressed sequence tag-derived microsatellite markers transferred to Musella lasiocarpa
Authors: W.J. Li, H. Ma, Z.H. Li, Y.M. Wan, X.X. Liu and C.L. Zhou
We assembled 31,308 publicly available Musa EST sequences into 21,129 unigenes; 4944 of them contained 5416 SSR motifs. In all, 238 unigenes flanking SSRs were randomly selected for primer design and then tested for amplification in Musella lasiocarpa. Seventy-eight primer pairs were found to be transferable to this species, and 49 displayed polymorphism... Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.6.13
- DOI:
- 10.4238/2012.August.6.13
Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population
Authors: J.M. Moreno-Ortiz, M. GutiÃ?©rrez-Angulo, M. Partida-PÃ?©rez, J. Peregrina-Sandoval, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz- endoza, S. SuÃ?¡rez-Villanueva, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, J.E. Cabrales-Vazquez and M.L. Ayala-Madrigal
Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.1
- DOI:
- 10.4238/2014.February.14.1
Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women
Authors: Y.P. Liu, D.W. Zhao, W.M. Wang, B.J. Wang, Y. Zhang and Z.G. Li
Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.9
- DOI:
- 10.4238/2014.February.14.9
Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women
Authors: W.G. Zhong, Y. Wang, H. Zhu and X. Zhao
Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. Inappropriate activation of the renin-angiotensin system may play a role in the development of preeclampsia. An insertion/deletion polymorphism in the angiotensin-converting enzyme gene (ACE-I/D) has been associated with differences i.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.21.1
- DOI:
- 10.4238/2012.May.21.1
Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility
Authors: L.Z. Zhang, Y.S. Li and H.Z. Liu
Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.48
- DOI:
- 10.4238/2015.November.18.48
Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians
Authors: Y. Zhang, Z.T. Wang and J. Zhong
The association between the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and gastric cancer has been widely evaluated, yet with conflicting results. Data were available from seven study populations involving 2600 subjects. Overall, comparison of alleles 609T and 609C indicated a significantly increased risk (46%) for gastric cancer (95.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.13.6
- DOI:
- 10.4238/2012.August.13.6
Microdeletion on 17p11.2 in a Smith-Magenis syndrome patient with mental retardation and congenital heart defect: first report from China
Authors: C. Huang, Y.-F. Yang, H. Zhang, L. Xie, J.-L. Chen, J. Wang, Z.-P. Tan and H. Luo
Smith-Magenis syndrome (SMS) is a rare syndrome with multiple congenital malformations, including development and mental retardation, behavioral problems and a distinct facial appearance. SMS is caused by haploinsufficiency of RAI1 (deletion or mutation of RAI1). We describe an eight-year-old female Chinese patient with multiple malformations, congenital .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.13.5
- DOI:
- 10.4238/2012.August.13.5
Discovery of a large set of SNP and SSR genetic markers by high-throughput sequencing of pepper (Capsicum annuum)
Authors: M. Nicola�¯, C. Pisani, J.-P. Bouchet, M. Vuylsteke and A. Palloix
Genetic markers based on single nucleotide polymorphisms (SNPs) are in increasing demand for genome mapping and fingerprinting of breeding populations in crop plants. Recent advances in high-throughput sequencing provide the opportunity for whole-genome resequencing and identification of allelic variants by mapping the reads to a reference genome. However.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.13.3
- DOI:
- 10.4238/2012.August.13.3