Polymorphism
Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer
Authors: J.Y. Liu, Q.M. Liu and L.R. Li
We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.19
- DOI:
- 10.4238/2015.August.28.19
Correlation between polymorphisms in the visfatin gene and its expression in the serum and coronary artery calcification
Authors: L.W. Jin, S.B. Zheng, Z.H. Zhou, S.F. Pan and Y. Zheng
We investigated the association between serum visfatin levels and single nucleotide polymorphisms (SNPs; rs61330082, rs2058539) in the visfatin gene and coronary artery calcification (CAC) in patients from Wenzhou, China. CAC patients (N = 206) were divided into two groups: mild CAC (MCAC) and moderate and severe CAC (MSCAC). .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028217
- DOI:
- 10.4238/gmr.15028217
Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk
Authors: G. Nie, C.L. Xie, Y.J. Cao, M.M. Xu, X. Shi, A.L. Zou and J.H. Qi
Previous studies examining the association between interleukin-6 (IL-6) -174G/C polymorphism and psoriasis risk have produced inconsistent results. The aim of this study was to offer a comprehensive review of the association between IL-6 -174G/C polymorphism and psoriasis risk through a meta-analysis. Literature search of PubM.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028255
- DOI:
- 10.4238/gmr.15028255
A comprehensive review of microRNA-related polymorphisms in gastric cancer
Authors: B.W. Han Z.H. Li, S.F. Liu, H.B. Han, S.J. Dong, H.J. Zou,R.F. Sun and J. Jia
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028289
- DOI:
- 10.4238/gmr.15028289
Association between monoamine oxidase B A644G polymorphism and Parkinson�s disease risk: a meta-analysis in the Chinese population
Authors: J.J. Liu, W. Wang, M. Meng, C.S. Liang and J.W. Zhang
Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphi.. Read More»
- Genet. Mol. Res. 15(2):
Association between atopic dermatitis-related single nucleotide polymorphisms rs4722404 and psoriasis vulgaris in a southern Chinese cohort
Authors: G. Shi, C.M. Cheng, T.T. Wang, S.J. Li, Y.M. Fan and K.J. Zhu
Genome-wide association studies have identified a single nucleotide polymorphism (SNP), rs4722404, in the caspase recruitment domain family member 11 (CARD11) gene, which is associated with atopic dermatitis. Previous genetic studies have also reported genomic similarities between psoriasis and atopic dermatitis. However, little is known regarding the ass.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028356
- DOI:
- 10.4238/gmr.15028356
Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis
Authors: Y.-F. Yu, Z.-G. Han, W.-B. Guo, G.-J. Zhang, J.-K. Yang, F.-L. Wu, Q.-Y. Ou, Y.-H. Li, X.-Y. Cai, Z.-N. Zhan, J.-H. Chen, W.-L. Xie, L. Tang and C.-D. Liu
It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.1
- DOI:
- 10.4238/2015.December.29.1
ORMDL3 variants associated with bronchiolitis susceptibility in a Chinese population
Authors: X.T. Liu, L. Ren, L.L. Zhou, Q.Y. Xiao, Y. Deng and E.M. Liu
Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibil.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.25
- DOI:
- 10.4238/2015.December.29.25
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer
Authors: J.P. Kleine, C.M. Camargo-Kosugi, C.V. Carvalho, F.C. Silva and I.D.C.G. Silva
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.3
- DOI:
- 10.4238/2015.December.29.3
Association of TNF-�± G308A gene polymorphism in essential hypertensive patients without type 2 diabetes mellitus
Authors: N. Ghodsian, M. Akhlaghi, V. Ramachandran, F. Heidari, P. Haghvirdizadeh, S.A. Eshkoor, A. Etemad, J.A. Jamaluddin and P. Ismail
This study aims to investigate the effects of tumor necrosis factor alpha (TNF-α) G308A gene polymorphism on essential hypertension (EHT) with or without type 2 diabetes mellitus (T2DM). The project was conducted on buccal epithelial and blood cells for case and control patients, respectively. Epithelial cells were obtained from the inner part of th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.4
- DOI:
- 10.4238/2015.December.29.4