Polymorphism
Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study
Authors: Y.N. Zhang, Y.J. Li, H. Li, H. Zhou and X.J. Shao
CD14 is involved in primary immune and inflammatory responses. The -159 C/T variation in the CD14 gene plays an important role in regulating CD14 expression and has been associated with the susceptibility to various diseases, including allergies. In this study, we examined the association between the C-159T polymorphism and atopic asthma susceptibility in.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.3
Association between RAGE gene polymorphisms and ulcerative colitis susceptibility: a case-control study in a Chinese Han population
Authors: Z.T. Wang, L.Y. Wang, L. Wang, S. Cheng, R. Fan, J. Zhou and J. Zhong
Ulcerative colitis (UC) is an immune-related disease with genetic predisposition. The aim of this study was to investigate the association of three polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with UC risk in a Chinese population. This case-control study involved 72 UC patients and 479 age- and gender-matched healthy contr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.34
- DOI:
- 10.4238/2015.December.29.34
Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia
Authors: Q.Y. Liu, F.Y. Gao, X.R. Liu, J. Li, M. Ji, J. Dong and X.T. Wang
In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.42
- DOI:
- 10.4238/2015.December.29.42
Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis
Authors: H.S. Zhu, J.F. Zhang, J.D. Zhou, M.J. Zhang and H.X. Hu
Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independent.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.43
- DOI:
- 10.4238/2015.December.29.43
Relationship between rs1047763 polymorphism of the C1GALT1 gene and susceptibility to immunoglobulin A nephropathy in Xinjiang Uyghur people
Authors: J.N. Xue, Y. Guo, X. Song, F. Xue, S.F. Yang, H. Jiang, R.Z.W.A. Bu-La and C. Lu
We explored the relationship between rs1047763, a single-nucleotide polymorphism (SNP) of the C1GALT1 gene, and genetic susceptibility to immunoglobulin A nephropathy (IgAN) in Xinjiang Uyghur people. The study comprised 90 patients with IgAN and 90 normal controls recruited from Uyghur people. The distribution of the rs1047763 polymorphism of C1GALT1 in .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.17
- DOI:
- 10.4238/2015.December.28.17
Y-STR INRA189 polymorphisms in Chinese yak breeds
Authors: Z.J. Ma, S.M. Chen, Y.G. Sun, Y.L. Xi, R.Z. Li, J.T. Xu and C.Z. Lei
To further explore Y-STR INRA189 polymorphisms in the yak, and to determine the genetic differences among yak breeds, genotyping analysis of INRA189 in 102 male yak individuals from three yak breeds in Qinghai Province of China was performed. Genotyping revealed the presence of four alleles, with sizes of 149, 155, 157, and 159 bp, respectively. Of these,.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.35
- DOI:
- 10.4238/2015.December.28.35
Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis
Authors: P.L. Chen, W.T. Li, J. Wang, Y.D. Jiang, P. Wu, T. Chen and S.B. Zheng
Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial. We performed a meta-analysis of previous studies and quantitatively estimated these associations. Pubmed, Embase, and Cochrane Library Database were searched f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.29
- DOI:
- 10.4238/2015.December.29.29
Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis
Authors: L. Yan, R. Hu, S. Tu, W.J. Cheng, Q. Zheng, J.W. Wang, W.S. Kan and Y.J. Ren
Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.32
- DOI:
- 10.4238/2015.December.29.32
Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis
Authors: J.M. Xu, X. Song, F. Gao and R. Wang
Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a meta-analysis. Articles.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.47
- DOI:
- 10.4238/2015.December.29.47
PPAR�³ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimerâ��s disease: a meta-analysis
Authors: Y.H. Lee and G.G. Song
We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferatoractivated receptor gamma (PPARg) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a metaanalysis of the associations between the PPARg Pro12Ala and His447His polymorphisms and AD in subjects. The meta-anal.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.18
- DOI:
- 10.4238/2015.June.29.18