Polymorphism
Genetic polymorphism at spinocerebellar ataxia 1 and 2 loci in Brazil
Authors: Stenio F.P. Duarte, Raquel S. Gestinari, M�¡rio Campos-Jr, M�¡rcia M.G. Pimentel, Marcelo A. Costa Lima
Dynamic mutation involves the expansion of a tandem arrayed DNA sequence that is polymorphic in the population. This mechanism is associated with neurological/neuromuscular disorders and the pathology depends on the extension of the repeated tract, with a specific threshold for each disease. We made a PCR-based characterizatio.. Read More»
- Genet. Mol. Res. 2(4):
Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in a Brazilian population
Authors: Ana Rossini, Davy C.M. Rapozo, LĂ?Âdia M.F. Amorim, Jacyara M.B. Macedo1, Raquel Medina, JosĂ?© F.N. Neto, ClĂ?¡udia V.M. Gallo and Luis F.R. Pinto
The glutathione S-transferase (GST) family of enzymes has a vital role in phase II of biotransformation of environmental carcinogens, pollutants, drugs and other xenobiotics. GSTs are polymorphic, with the type and frequency of polymorphism being ethnic dependent. Polymorphisms in GST genes have been shown to be associated wit.. Read More»
- Genet. Mol. Res. 1(3):
Transferrin polymorphism in Central Amazon populations of pescada, Plagioscion squamosissimus
Authors: Aylton Saturnino Teixeira, Alan Jamieson and Jos�© Carlos Paula Raposo
lood plasma of 253 specimens from eight population samples of the sciaenid fish, pescada (Plagioscion squamosissimus), caught from four sites in the Central Amazon, was tested for molecular variants of transferrin. Starch gel electrophoresis was used to distinguish six species of transferrin molecules; 12 of the 21 theoretical.. Read More»
- Genet. Mol. Res. 1(3):
Frequency of the hypervariable DNA loci D18S849, D3S1744, D12S1090 and D1S80 in a mixed ancestry population of Chilean blood donors
Authors: M. Acu�±a, H. Jorquera, L. Cifuentes and L. Armanet
Blood donors (N = 150) at San José Hospital (Santiago, Chile) were typed for one VNTR locus (D1S80) and three STR loci (D18S849, D3S1744, D12S1090). A questionnaire was used to determine the socioeconomic level of the donors, because it is known that some genetic markers (e.g., the ABO and Rh groups) are differentially .. Read More»
- Genet. Mol. Res. 1(2):
Rapid identification of single nucleotide polymorphisms by fluorescence-based capillary electrophoresis
Authors: Montse Bernat, Esther Titos and Joan Cl� ria
We describe the application of two different fluorescence- based techniques (ddNTP primer extension and single-strand conformation polymorphism (SSCP)) to the detection of single nucleotide polymorphisms (SNPs) by capillary electrophoresis. The ddNTP primer extension technique is based on the extension, in the presence of fluo.. Read More»
- Genet. Mol. Res. 1(1):
Detection of stabilizing selection in favor of the Santa Cruz homokaryotype in Drosophila pseudoobscura populations from the high plateau of the Colombian Andes
Authors: Diana Alvarez, Manuel Ruiz-Garcia, Jimena Guerrero and Juan P. Jaramillo
Chromosome 3 rearrangements were studied in five Drosophila pseudoobscura populations from the high plateau of the Colombian Andes. As in previous studies, the Santa Cruz and Tree Line rearrangements were predominant in these populations, but for the first time other rearrangements such as the Olympic, Cuernavaca and a rearran.. Read More»
- Genet. Mol. Res. 1(1):