Polymorphism
Thymidylate synthase enhancer region polymorphism not related to susceptibility to acute lymphoblastic leukemia in the Kashmir population
Authors: F.H. Nazki, A. Masood, M.A. Banday, A. Bhat and B.A. Ganai
Thymidylate synthase (TS) is a crucial enzyme in folate metabolism and plays a vital role in DNA synthesis and repair. The most common polymorphism in TS is a unique double (2R) or triple (3R) 28-bp tandem repeat sequence in the enhancer region of the TS gene (TSER). This genetic variation in TSER has been widely investigated .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.10.6
- DOI:
- 10.4238/2012.April.10.6
Association of the CYP4F2 rs2108622 genetic polymorphism with hypertension: a meta-analysis
Authors: X.-H. Luo, G.-R. Li and H.-Y. Li
Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.1
- DOI:
- 10.4238/2015.November.25.1
Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of chromosome abnormalities or polymorphisms
Authors: Y. Dong, L.L. Li, R.X. Wang, X.W. Yu, X. Yun and R.Z. Liu
The subsequent reproductive outcomes in couples with a history of recurrent pregnancy loss (RPL) associated with chromosome abnormalities or polymorphisms are generally not reported in China. Many RPL carrier couples have decided not to have children. The present study recorded the subsequent delivery, miscarriage, and unpregn.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.17.4
- DOI:
- 10.4238/2014.January.17.4
GSTT1, GSTM1, and GSTP1 polymorphisms as a prognostic factor in women with breast cancer
Authors: A.L. Oliveira, F.F. Oliveira Rodrigues, R.E. dos Santos, R.L. Rozenowicz and M. Barbosa de Melo
The glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.January.22.9
- DOI:
- 10.4238/2014.January.22.9
A SNP in the 3'-UTR of HSF1 in dairy cattle affects binding of target bta-miR-484
Authors: Q.L. Li, Z.F. Zhang, P. Xia, Y.J. Wang, Z.Y. Wu, Y.H. Jia, S.M. Chang and M.X. Chu
The heat shock transcription factor 1 gene (HSF1) plays a key role in the heat stress response. We previously found a single nucleotide polymorphism (SNP) in the 3'-untranslated region (g.4693G>T) of HSF1 that was related to thermo tolerance in Chinese Holstein cattle through association analysis. However, it is not known w.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.18
- DOI:
- 10.4238/2015.October.19.18
Genetic polymorphisms in �²-defensin II gene in Amazon sheep from Brazil
Authors: B.B. Souza, E.M. Barbosa, J.S.N. Azevedo, J.E.G. Campelo,L.F.S. Rodrigues, L.M.L. Pinheiro, S.C.B Silva, A.S. Schierholt, P.H. Souza, E.C. Gon�§alves and E. Silva Filho
The northern region of Brazil produces a large number of sheep, with Pará being the largest sheep breeding state in the region. In the Amazon region, livestock production is a challenge due to the high diversity of pathogens affecting humans and animals. Defensins are antimicrobial peptides acting as a first barrier aga.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.24
- DOI:
- 10.4238/2015.October.19.24
Association of CD226 polymorphisms with the susceptibility to type 1 diabetes in Chinese children
Authors: J.S. Xi, C.L. Nie, J. Wang, Y. Ma and A.H. Ma
Polymorphisms in the CD226 gene have been reported to be associated with autoimmune diseases. The aim of our study was to investigate the association between two single nucleotide polymorphisms (SNPs) (rs763361 and rs727088) in the CD226 gene and the risk for developing type 1 diabetes (T1D) in Chinese Han children. This case-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.25.13
- DOI:
- 10.4238/2015.November.25.13
NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans
Authors: Q. Zhang, H.W. Fan, J.Z. Zhang, Y.M. Wang and H.J. Xing
Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.17
- DOI:
- 10.4238/2015.October.29.17
Angiotensin-converting enzyme gene I/D dimorphism does not play a major role in the susceptibility of Malaysian systemic lupus erythematosus patients
Authors: L.-H. Lian, T.-P. Lau, A.-S. Ching and K.-H. Chua
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes systemic damage, involving auto-reactive antibodies and over-deposition of immune complexes. Susceptibility to SLE is believed to be multifactorial, and genetics is one of the proven etiological factors; it can affect SLE development, severity and prognosi.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.10.2
- DOI:
- 10.4238/2012.April.10.2
Sex differential marker FD for rapid sex identification of Litsea cubeba
Authors: Q. Wu, Y. Chen, Y. Wang and L. Lin
Litsea cubeba is an important economic tree in China. Sex identification of the species is required to reduce breeding costs. Molecular biology is an ideal method to achieve this aim because of the lack of morphological differences between male and female plants, especially at the seedling stage. Sequence-related amplified pol.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.1
- DOI:
- 10.4238/2015.October.21.1