Polymorphism
Discovery and characterization of a first set of polymorphic microsatellite markers in Siganus oramin
Authors: Y.-X. Liu, C.-Y. Ma, H.-Y. Ma, C.-L. Feng, S.-J. Li and L.-B. Ma
Nine microsatellite DNA markers were developed and characterized for Siganus oramin by the 5'-anchored polymerase chain reaction technique. A total of 42 alleles were identified in 30 individuals, and the number of alleles per locus ranged from 3 to 7, with an average of 4.7. The observed and expected heterozygosity p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.8
- DOI:
- 10.4238/2015.November.30.8
Genome-wide association study of growth traits in the Jinghai Yellow chicken
Authors: G.X. Zhang, Q.C. Fan, T. Zhang, J.Y. Wang, W.H. Wang, Q. Xue and Y.J. Wang
Growth is one of the most economically important traits in the poultry industry. In this study, we identified single-nucleotide polymorphisms (SNPs) and candidate genes associated with growth traits of the Jinghai Yellow chicken. Genome-wide association studies were conducted using the Illumina 60 K SNP Chicken array to genoty.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.10
- DOI:
- 10.4238/2015.November.30.10
An let-7 KRAS rs712 polymorphism increases hepatocellular carcinoma risk
Authors: D. Xiong1*, Y.P. Song2*, W. Xiong3 and Y.D. Liang2
KRAS, also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, acts as an intracellular signal transducer. The oncogenic KRAS mutation is an essential step in the development of many types of human cancers, including hepatocellular carcinoma. Here we aimed to investigate the relationship between KRAS rs712 polymorphisms and hepatocellular carci.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.24
- DOI:
- 10.4238/2015.October.29.24
Rapid microsatellite development in Gekko japonicus using sequenced restriction-site associated DNA markers
Authors: L. Wei1, W.W. Shao1, H.B. Zhou2, J. Ping2, L.M. Li3 and Y.P. Zhang2
welve polymorphic microsatellite loci were isolated in the Japanese gecko, Gekko japonicus. We genotyped one population from Wenzhou, Zhejiang Province, China (N = 36). The mean number of observed alleles per locus was 7.3 (range 4 to 13). Observed and expected heterozygosity values ranged from 0.200 to 0.944 and from 0.395 to 0.797, respectively. One loc.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.32
- DOI:
- 10.4238/2015.October.29.32
Lack of association between rare mutations of the SIAE gene and rheumatoid arthritis in a Han Chinese population
Authors: D.D. Zhang1,2*, F. He3*, H.T. Liu4*, F. Hao1 and J. Zhu5
The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous. We determined whether mutations in the SIAE gene are responsible for RA in a Han Chinese population.DNA was prepared from the venous leukocytes of 444 RA patients and 647 normal con.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.38
- DOI:
- 10.4238/2015.October.29.38
Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk
Authors: J. Wang*, S. Yang*, F.H. Guo, X. Mao, H. Zhou, Y.Q. Dong, Z.M. Wang andF. Luo
The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.13
- DOI:
- 10.4238/2015.November.13.13
Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population
Authors: Y.K. Wei1, H.L. Ma2, Y.Z. Guo3, B.H. Yang1 and W.X. Pang3
The aim of our study was to conduct a case-control study in a Chinese postmenopausal population to evaluate the roles of the IGF-1 rs35767 and rs972936 polymorphisms on bone mineral density (BMD) levels and osteoporosis risk. A total of 272 consecutive postmenopausal women with a primary diagnosis of osteoporosis and 272 controls were enrolled in the stud.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.17
- DOI:
- 10.4238/2015.November.13.17
Development of transcript-associated microsatellite markers in Ancherythoculter nigrocauda and cross-amplification in Culter alburnus
Authors: Y. Sun1,2, Q. Li1, G. Wang1, D. Zhu1, J. Chen1 and P. Li1
Twenty-eight polymorphic microsatellite markers were developed from the transcriptome of Ancherythoculter nigrocauda. These loci were used to characterize the genotypes of 48 individuals. The observed number of alleles per locus ranged from 5 to 11, with an average of 7.7. Expected and observed heterozygosities ranged from 0.437 to 0.978 and from 0.373 to.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.13.12
- DOI:
- 10.4238/2015.November.13.12
Vascular endothelial growth factor gene polymorphisms and psoriasis susceptibility: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to explore whether vascular endothelial growth factor (VEGF) polymorphisms confer susceptibility to psoriasis. Meta-analyses were conducted to examine the associations between the +405 C/G, -460 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and psoriasis using allele contrast and recessive, dominant, and addi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.3
- DOI:
- 10.4238/2015.November.18.3
Molecular characterization, expression, polymorphism of NR5A2 and its relationship with litter size in Hu sheep
Authors: Y.X. Li, J. Zhang, Y. Qian, C.H. Meng, H.L. Wang, X.J. Tao, S. Zhong, S.X. Cao and Q.F. Li
NR5A2 has been implicated in processes as diverse as steroidogenesis, cellular proliferation, ovarian follicular development, ovulation, and fertility in mammals. However, data about the relationship between NR5A2 and prolificacy in mammals are lacking. In the present study, we identified and characterized NR5A2 of Hu sheep, a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.20
- DOI:
- 10.4238/2015.October.19.20