Polymorphism
Association between a functional genetic polymorphism (rs2230199) and age-related macular degeneration risk: a meta-analysis
Authors: M.X. Zhang, X.F. Zhao, Y.C. Ren, T.T. Geng, H. Yang, T. Feng, T.B. Jin and C. Chen
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results are not consistent among studies. The aim of this study was to perform a meta-analysis of all available studies on this SNP in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.24
- DOI:
- 10.4238/2015.October.16.24
Correlation between polymorphisms of hypoxia-inducible factor-1�± Pro582Ser and type 2 diabetic nephropathy
Authors: Y.X. Bi*, L. Yu* and G.X. Jin
We examined the correlation between gene polymorphisms in hypoxia-inducible factor-1α (HIF-1α) Pro582Ser and type 2 diabetic nephropathy (DN). A total of 244 subjects with type 2 diabetes were recruited. The 1285-bp locus polymorphism of HIF-1α exon was detected using polymerase chain reaction-restriction fragment length polymorphism. C/.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.13
- DOI:
- 10.4238/2015.November.18.13
Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma
Authors: G.L. Hu, G. Ma and J.H. Ming
We conducted a case-control study to assess the role of vascular endothelial growth factor (VEGF) -634G/C, +936C/T, and +1612G/A genetic variations in the development of osteosarcoma in a Chinese population. This hospital-based case-control study examined 130 patients with osteosarcoma and 130 age- and gender-matched healthy controls from March 2011 and M.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.19
- DOI:
- 10.4238/2015.November.18.19
Genomic selection for slaughter age in pigs using the Cox frailty model
Authors: V.S. Santos, S. Martins Filho, M.D.V. Resende, C.F. Azevedo, P.S. Lopes, S.E.F. Guimar�£es, L.S. Gl�³ria and F.F. Silva
The aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorph.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.19.5
- DOI:
- 10.4238/2015.October.19.5
Correlation between chromosomal polymorphisms and male infertility in a Northeast Chinese population
Authors: L.L. Li, D. Peng, R.X. Wang, H.B. Zhu, W.J. Wang, R.Z. Liu
The aim of this study was to evaluate the correlation between chromosomal polymorphisms and male infertility. The patients were diagnosed with azoospermia or oligospermiaby a semen analysis. Chromosomal analysis was performed on peripheral blood lymphocytes obtained from the patients, with standard G-banding and C-banding. Y c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.21
- DOI:
- 10.4238/2015.November.30.21
Association between alcohol dehydrogenase 1C gene *1/*2 polymorphism and pancreatitis risk: a meta-analysis
Authors: F. Fang, J. Pan, G.H. Su, L.X. Xu, G. Li, Z.H. Li, H. Zhao and J. Wang
Numerous studies have focused on the relationship between alcohol dehydrogenase 1C gene (ADH1C) *1/*2 polymorphism (Ile350Val, rs698, also known as ADH1C *1/*2) and pancreatitis risk, but the results have been inconsistent. Thus, we conducted a meta-analysis to more precisely estimate this associati.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.2
- DOI:
- 10.4238/2015.November.30.2
Association of interleukin gene polymorphisms with the risk of coronary artery disease
Authors: H.T. Yang, S.L. Wang, L.J. Yan, P. Qian and H.Y. Duanb
We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). A total of 410 individuals with CAD were enrol.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.16
- DOI:
- 10.4238/2015.October.16.16
Detection of a novel single nucleotide polymorphism and imprinted status analysis of the Ras protein-specific guanine nucleotide-releasing factor 1 gene in domestic pigs
Authors: Y.Y. Ding, L.Y. Liu*, J. Zhou, X.D. Zhang, L. Huang, S.J. Zhang and Z.J. Yin
The aim of this study was to determine the imprinting status of the Ras protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1) gene in domestic pigs. In this study, a 228-bp partial sequence located in exon 14 and a 193-bp partial sequence located in exon 1 of the Rasgrf1 gene in domestic pigs were obtained... Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.20
- DOI:
- 10.4238/2014.December.12.20
Association of a hypoxia-inducible factor-3�± gene polymorphism with superovulation traits in Changbaishan black cattle
Authors: Q. Deng, Y. Gao, H. Jiang, C.Z. Chen, C.H. Li, W.L. Yu, X. Chen and J.B. Zhang
This study was designed to examine a single nucleotide polymorphism (SNP) in the HIF-3α gene in three hundred Changbaishan black cattle using PCR-restriction fragment length polymorphism to determine whether there is an association between this SNP and superovulation. The cloning and sequencing results indicate that the polymorphism is due to a poin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.17
- DOI:
- 10.4238/2015.November.18.17
Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population
Authors: C.M. Wang, H.D. Ye, Y.R. Li, Q.X. Hong, L.L. Tang, A.N. Zhou, M.Q. Xu and S.W. Duan
Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.14
- DOI:
- 10.4238/2015.October.9.14