Polymorphism
Interaction of six candidate genes in essential hypertension
Authors: D.C. Hu, X.L. Zhao, J.C. Shao, W. Wang, J. Qian, A.H. Chen, H.Q. Zhang, H. Guo, J. Jiang and H.Y. Li
We explored the interaction of 6 candidate genetic mutations in essential hypertension (EH). The mutations AGT M235T, ACE I/D, eNOS Glu298Asp, ET-2 A985G, ANP T2238C, and NPRC A-55C were detected using a genechip microarray in 100 patients with EH and 97 controls from the Han population living in the Yunnan Province of China. Risks of EH were evaluated wi.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.October.20.14
- DOI:
- 10.4238/2014.October.20.14
MEF2A gene mutations and susceptibility to coronary artery disease in the Chinese population
Authors: J. Li1, H.-X. Chen2, J.-G. Yang3, W. Li3, R. Du3 and L. Tian3
We investigated mutations and polymorphisms of the coronary artery disease (CAD)-related myocyte enhancer factor 2A (MEF2A) gene in a Chinese population. Polymerase chain reaction-single-strand conformation polymorphism and DNA sequencing were used to detect exon 11 of the MEF2A gene in 210 Hubei patients with CAD and 190 healthy controls... Read More»
- Genet. Mol. Res. 13(4):
- /2014.October.20.15
- DOI:
- /10.4238/2014.October.20.15
R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran
Authors: H.-R. Kouhpayeh, M. Hashemi, S.-A. Hashemi, A. Moazeni-Roodi, M. Naderi, B. Sharifi-Mood, M. Taheri, M. Mohammadi and S. Ghavami
The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase, is considered an important regulator of T-cell activation. We investigated a possible association between the PTPN22 C1858T (R620W) polymorphism and pulmonary tuberculosis in an Iranian population... Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.6
- DOI:
- 10.4238/2012.April.27.6
Association analysis of IL-17A and IL-17F polymorphisms in Chinese women with cervical cancer
Authors: L. Li, Y.L. Tian, X.M. Lv, H.F. Yu, Y.Y. Xie, J.D. Wang and W. Shi
We selected six tagged single nucleotide polymorphisms (SNPs) in the interleukin 17A (IL-17A) and IL-17F genes, and evaluated the relationship between the six common SNPs and environmental factors in cervical cancer patients. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the IL-17A (rs22.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.6
- DOI:
- 10.4238/2015.October.9.6
Assessment of correlation between pre-miRNA-1757 polymorphism and chicken performance traits
Authors: H. Li, K.R. Jiang, S.H. Wang, X.J. Liu, X.T. Kang, R.R. Jiang,Z.J. Li and G.R. Sun
Single nucleotide polymorphism in microRNAs (miRNA) may influence their target gene selection and regulation efficiency, leading to animal phenotypic variation. The aim of this study was to evaluate the possible effect of single nucleotide polymorphisms in the miRNA-1757 gene precursor region (pre-mir-1757) on economic-related.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.7
- DOI:
- 10.4238/2015.October.9.7
Characterization and development of chloroplast microsatellite markers for Gossypium hirsutum, and cross-species amplification in other Gossypium species
Authors: X.Y. Cai, F. Liu, Z.L. Zhou, X.X. Wang, C.Y. Wang, Y.H. Wang and K.B. Wang
Cotton is an important economic crop worldwide; its fiber, commonly known as cotton lint, is the main natural source for the textile industry. Sixty chloroplast microsatellites were identified and characterized from the complete sequence of the Gossypium hirsutum chloroplast genome using a bioinformatic approach. Twenty chloro.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.6
- DOI:
- 10.4238/2015.October.5.6
Arylamine N-acetyltransferase 2 genotypes in a Mexican population..
Authors: L. Taja-Chayeb, J.A. Ag�ºndez, C. Miguez-Mu�±oz, A. Chavez-Blanco and A. Due�±as-Gonzalez
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican popu.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.7
- DOI:
- 10.4238/2012.April.27.7
Single nucleotide polymorphisms of Ã?Â?6-desaturase and Elovl5 segments and their associations with common carp (Cyprinus carpio) growth traits
Authors: H. Ren, J. Yu, P. Xu and Y. Tang
Highly unsaturated fatty acids (HUFAs) are crucial for the nutritional health, physiology, and reproduction of vertebrates. The Δ6-desaturase and Elovl5 elongase genes produce essential enzymes in the biosynthetic pathway of HUFAs. Single nucleotide polymorphism (SNP) analysis of genes functionally related to the growth traits of the common carp (Cy.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.4
- DOI:
- 10.4238/2015.October.21.4
DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma: a case-control study
Authors: X.M. Zhang, S. Li and Q.M. Zhang
A variety of molecular epidemiological studies have been conducted to examine the association between the DNMT3B -149C/T polymorphism and cancer susceptibility; however, there has been no study investigating the association between the DNMT3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma (LSCC) until now. To determine the role of .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.6
- DOI:
- 10.4238/2015.October.21.6
Association of A-20C polymorphism in the angiotensinogen gene with essential hypertension: a meta-analysis
Authors: R. Zeng, Q.P. Wang, M.X. Fang, J. Zhuang and R.X. Fan
The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. In this study, we performed a meta-analysis to assess the association between AGT A-20C polymorphism and essential hypertension. Published literature was retrieved .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.19
- DOI:
- 10.4238/2015.October.21.19