Polymorphism
Association of CRTC2 gene polymorphisms with growth and meat quality traits of Qinchuan cattle
Authors: H.C. Xu, L.S. Gui, N. Song, Y.Y. Zhang, H.C.Wang and L.S. Zan
Growth and meat quality traits play important roles in the evaluation of cattle productivity and are influenced by genetic and environmental factors. CRTC2 is a recently discovered gene related to obesity that may influence fat deposition. The aim of the current study was to detect polymorphisms of bovine CRTC2 and explore their relationships to growth an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.12
- DOI:
- 10.4238/2015.October.21.12
Effect of IL-1�², IL-8, and IL-10 polymorphisms on the development of myocardial infarction
Authors: S. Wang, Y.X. Dai, L.L. Chen, T. Jiang, M.Q. Zheng, C.G. Li, Y.P. Chen, W.H. Lin, J.F. Zhang and J. Jiang
Myocardial infarction (MI) is currently a leading cause of death worldwide, and is caused by various environmental and genetic factors. We therefore conducted a case-control study to investigate the association between polymorphisms in interleukins IL-1β, IL-8, and IL-10 and MI risk. This study recruited 260 MI patients a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.14
- DOI:
- 10.4238/2015.October.5.14
CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis
Authors: H.W. Lu, M. Huang, J.H. Wang, X.L. Sun and Y.Q. Ke
The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.5.20
- DOI:
- 10.4238/2015.October.5.20
Molecular characterization, tissue expression profile and SNP analysis of porcine GLP2R
Authors: Y.L. Chai, H.M. Ma and J. Jiang
Glucagon-like peptide-2 receptor (GLP2R), a member of the G-protein-coupled receptor family, plays an important role in intramuscular fat formation. Little is known, however, about porcine GLP2R. In the present study, GLP2R was cloned, and its expression in pig muscle characterized. By rapid amplification of cDNA ends, gene sequence was obtained from Shaz.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.14
- DOI:
- 10.4238/2015.October.21.14
Influence of ERCC2 gene polymorphisms on the treatment outcome of osteosarcoma
Authors: Z.F. Liu, A.L.J. Asila, K. Aikenmu, J. Zhao, Q.C. Meng and R. Fang
We conducted a prospective study to investigate the role of ERCC2 gene polymorphisms on the outcome of cisplatin-based treatment in patients with osteosarcoma. A total of 115 patients with osteosarcoma were included in our study. Genotyping of ERCC2 Asn312Asp (rs1799793) and Lys751Gln (rs13181) was performed using a matrix-assisted laser desorption/ioniza.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.17
- DOI:
- 10.4238/2015.October.21.17
Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population
Authors: J.Y. Li, F. Tao, X.X. Wu, Y.Z. Tan, L. He and H. Lu
Impaired antioxidant defense increases the oxidative stress and contributes to the development of type 2 diabetes mellitus (T2DM). MnSOD and eNOS are important antioxidant enzymes. This aim of this study was to verify the association of MnSOD and eNOS tagSNPs with T2DM in a Chinese Han population. Four tagSNPs of MnSOD and eight tagSNPs of eNOS were detec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.21.20
- DOI:
- 10.4238/2015.October.21.20
G-395A polymorphism in the promoter region of the KLOTHO gene and hypertension among elderly (90 years and older) Chinese individuals
Authors: L.L. Gao, X. Ding, D.M. Xie, M. Yang and B.R. Dong
The aim of this study was to examine the possible associations between the KLOTHO G-395A gene polymorphism and hypertension in Chinese nonagenarians and centenarians. The G-395A (rs1207568) in the promoter region of the KLOTHO gene was genotyped using a standard TaqMan allelic discrimination assay. We include.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.22
- DOI:
- 10.4238/2015.November.30.22
Association between the interleukin-6 -174 G/C polymorphism and risk of ischemic stroke: a meta-analysis
Authors: X.F. Jin, D.L. Wang2, Y. Zhou and H. Xiong
Numerous studies have evaluated the association between the -174 G/C polymorphism in the interleukin-6 (IL6) gene and ischemic stroke risk. However, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of the IL6 -174 G/C polymorphism with ischemic stroke. Published literatures from PubMed and Embase da.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.3
- DOI:
- 10.4238/2015.October.26.3
729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer
Authors: B. Wan, J. Tan, Q. Zeng, L.Y. He, Y. Gan, Y.B. Dai and K. Yao
In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 20.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.26
- DOI:
- 10.4238/2015.November.30.26
RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer
Authors: S. SuÃ?¡rez-Villanueva, M.L. Ayala-Madrigal, J. Peregrina-Sandoval, N. MacÃ?Âas-GÃ?³mez, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz-Mendoza, J.M. Moreno-Ortiz, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, E. Cabrales and M. GutiÃ?©rrez-Angulo
We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC). Genomic DNA samples were obtained from the peripheral blood of 176 Mexican patients with CRC at diagnosis and from 195 individuals that formed the control group. The polymorphisms were detected b.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.28
- DOI:
- 10.4238/2015.November.30.28