Polymorphism
Association of the GSTM1 null polymorphism with breast cancer in a Mexican population
Authors: O. Soto-Quintana, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez, R. RamÃ?Ârez-PatiÃ?±o, A. Ramos-Silva, L.E. Figuera, D.I. Carrillo-Moreno, I.A. GutiÃ?©rrez-Hurtado, A.M. Puebla-PÃ?©rez, B. SÃ?¡nchez-Llamas and M.P. Gallegos-Arreola
The glutathione S transferase (GST) family plays an important role in the processing of carcinogens. Data on the null GSTM1 genotype has revealed associations with cancer, and has been suggested to affect carcinogen metabolism and to contribute to tumor promotion inthe mammary gland. We examined the role of the null GSTM1 genotype by comparing the genotyp.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.2
- DOI:
- 10.4238/2015.October.26.2
Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease
Authors: C.M. Yun and X.Y. Sang
We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.18
- DOI:
- 10.4238/2015.October.26.18
Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer
Authors: W.T. Qi, J.L. Gao and S.S. Zhang
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were collected between May 2012 and May 2014. The SNP genotyping of IL-17A rs2275913G>A .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.33
- DOI:
- 10.4238/2015.October.26.33
Genetic polymorphisms and retinal vein occlusion in an Italian population
Authors: L. De Polo, P.E. Maltese, E. Rigoni, M. Bertelli, S. Cecchin, G. Staurenghi and G. Stoppa
In this study, we assessed the prevalence of polymorphisms in genes involved in hyperhomocysteinemia or hemostasis to shed light on their role, if any, in retinal vein occlusion (RVO). We recruited 37 Italian patients (17 men and 20 women) with a diagnosis of central or branch RVO based on fundus examination and retinal fluorescein angiography, as well as.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.30
- DOI:
- 10.4238/2015.October.26.30
Differentiation of four strains of Chinese soft-shelled turtle (Pelodiscus sinensis) based on high-resolution melting analysis of single nucleotide polymorphism sites in mitochondrial DNA
Authors: H.Q. Zhang, C. Zhang, X.J. Xu, J.J. Zhu, Z.Y. He and J.Z. Shao
The Chinese soft-shelled turtle (Pelodiscus sinensis) has been one of the most economically important aquatic animals in China for thousands of years, and several breeding strains have been formed. Since the morphological characteristics of some strains are similar, a rapid and accurate molecular method to differentiate between strains is required. In thi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.10
- DOI:
- 10.4238/2015.October.26.10
Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: a meta-analysis
Authors: C.C. Guo, W.H. Huang, N. Zhang, F. Dong, L.P. Jing, Y. Liu, X.G. Ye, D. Xiao, M.L. Ou, B.H. Zhang, M. Wang, W.K. Liang, G. Yang and C.X. Jing
Celiac disease (CD) is a common autoimmune disorder characterized by heightened immunological response to ingested gluten. Certain gene polymorphisms of IL2/IL21 (rs6822844 and rs6840978) and SH2B3 (rs3184504) may influence susceptibility to CD, although the effects remain unclear. We performed a meta-analysis of the associations between rs6822844, rs6840.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.19
- DOI:
- 10.4238/2015.October.26.19
Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia
Authors: D.M. Fan, Y. Wang, X.L. Liu, A. Zhang and Q. Xu
Preeclampsia is a common condition unique to pregnant women. Previous studies have suggested that several cytokines may contribute to defective placental invasion and endothelial damage in this condition. We investigated the influence of four single nucleotide polymorphisms (SNPs) in the promoters of IL-6 (-572G/C, -597G/A, an.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018588
- DOI:
- 10.4238/gmr16018588
C3435T polymorphism of the MDR1 gene is not associated with blood levels of hypothalamus-pituitary-adrenal axis hormones in healthy male subjects
Authors: A. Suzuki, Y. Matsumoto, T. Shirata, K. Goto, M. Enokido, K. Otani
In vitro studies have shown that multidrug resistance protein 1 (MDR1) has an affinity for cortisol; however, in vivo association studies on the relationship between MDR1 gene polymorphisms and blood cortisol levels have produced inconsistent results. Therefore, we examined the effects of the C3435T polymorphism of the MDR1 ge.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019447
- DOI:
- 10.4238/gmr16019447
Changes on microsatellites of expressed sequence tag of sugarcane (Saccharum spp) during vegetative propagation
Authors: R. Augusto, R.C. Maranho, C.A. Mangolin, J.C. Bespalhok Filho and M.F.P.S. Machado
The reduction in sugarcane productivity in subsequent cutting stages may be related to a gradual decrease of the allele number and mean observed heterozygosity (HO) in the sugarcane ratoon. This hypothesis was tested assessing the number of alleles and HO values in 10 expressed sequence tag microsatellites (Est-SSR loci) of th.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019519
- DOI:
- 10.4238/gmr16019519
GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis
Authors: D.A. Rodrigues, J.V.M. Martins, K.S.F. e Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura
Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include h.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019101
- DOI:
- 10.4238/gmr16019101