Polymorphism
Genetic Polymorphism in Endometriosis: Trends in Scientific Production
Authors: Maria Gabriela Machado Junqueira, Amanda Fernandes Costa, Felipe de Ara?ºjo Nascimento, K?¡tia Karina Verolli de Oliveira Moura, Fl?¡via Melo Rodrigues
Endometriosis is characterized by the presence of endometrial tissue located outside the uterine cavity. The prevalence is around 6 to 10%. Regarding etiopathogenesis, several theories are accepted, but alterations in the molecular biology of the endometrium seem to be fundamental for the development of endometriosis. Women wi.. Read More»
- Genet. Mol. Res. 17(1):
- gmr16039891
- DOI:
- 10.4238/gmr16039891
Genetic diversity assessment of Allium cepa L. cultivars from Bosnia and Herzegovina using SSR makers
Authors: Lutvija Kari??, Maryam Golzardi, Petar Glamo?lija, Jasmin ? utkovi??
The five most common cultivars from the genus Allium cepa L. in Bosnia and Herzegovina (BiH) were analysed, focusing on Konjic onion. Seven SSR markers for genetic similarity analysis were used to address the genetic backgrounds. The polymorphic relationship between the SSR markers was analyzed by using Polymorphic Informatio.. Read More»
- Genet. Mol. Res. 17(1):
- gmr16039870
- DOI:
- 10.4238/gmr16039870
Effect of genetic polymorphism of ?±S1- casein gene on qualitative and quantitative milk traits in native Bulgarian Rhodopean cattle breed
Authors: J Peter Hristov, Denitsa Teofanova, Ani Georgieva, Georgi Radoslavov
Milk protein genetic polymorphisms of the genus Bos provoke a significant scientific interest, mainly associated with their evolution, population structure, breeding and hybridization. The aim of present study is to investigate the influence of the genetic variants of αS1- casein gene with respect to milk production and .. Read More»
- Genet. Mol. Res. 17(1):
- gmr16039868
- DOI:
- 10.4238/gmr16039868
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Authors: R.S. Mascarenhas, F.R.B. Oliveira, J.F. Corr?ªa, K.S.F. e Silva, I.R. Costa, A.M. Barbosa, M.H. Lagares, F.L. Campedelli, M.P. de Morais, J.V.M. Martins, D.A. Rodrigues, e K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039836
- DOI:
- 10.4238/gmr16039836
Protein Z gene variants and risk of Idiopathic Recurrent Pregnancy Loss in Saudi Arabian women
Authors: Walid Zammiti, Sarra Said, Amani Shaman, Faisel Mohammed Abu-Duhier
Background: Protein Z (PZ) is a vitamin K-dependent plasma glycoprotein, it plays a key role in the physiologic inhibition of coagulation by acting as a cofactor in the inactivation of factor Xa. The relationship between PZ gene polymorphisms and pregnancy loss is controversial. To address this, we investigate the association .. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039834
- DOI:
- 10.4238/gmr16039834
The correlation analysis of polymorphisms of Prion-Related Doppel (PRND) with prion (PRNP) alleles in Gansu Alpine Merino sheep
Authors: Yuan-zi Liu, Chun-lin Zhao, Yu-Ze Yang, Run Wu, Chuan Wang, Xue-Rui Wan1, Yan Wang
The interaction between the ovine prion protein gene (PRNP) and Doppel (PRND) gene polymorphisms is essential for understanding the role of prion proteins in scrapie. In this study, the blood genomic DNA samples of 111 Gansu Alpine Merino sheep were used to define the PRNP alleles and the haplotypes of PRND by PCR-SSCP (single.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039832
- DOI:
- 10.4238/gmr16039832
Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features
Authors: J.T. Takamori, M. Santos, G. T. Peterle, L. Rossi, O. A. Curioni, D. Gazito, L. L. Maia, I. D. Louro, M. M. de Oliveira, J. G. dos Santos, R. A. Moyses, P. M. Cury, T. N. Toporcov, J. L. Kanda, A. M. A. da Silva, M. B. de Carvalho
Oral cancer incidence is higher in individuals between the fifth and seventh decades of life, but some studies indicate a decreasing age trend. From the epidemiological point of view, alcohol consumption is associated with the emergence of oral cancer by interfering with mechanisms of DNA synthesis and repair. From a genetic s.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039829
- DOI:
- 10.4238/gmr16039829
AluYb8 insertion in the WNK1 gene is not associated with hypertension in a Russian Caucasian population
Authors: Elmira Akhmedova, Svetlana Y. Nikulina, Alla B. Salmina, Anna Chernova, Marina Bazanova, Anna Ohapkina, Aleksey Semenchukov, Paolo E. Maltese, Elena Manara and Matteo Bertelli
WNK1 (With No-lysine Kinase 1), a serine-threonine kinase, regulates blood pressure by acting on various sodium transport-related ion channels. Several studies report a link between common variants of the WNK1 gene and hypertension. No data exists on Russian populations. Our aim was to evaluate the association between the WNK1.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039809
- DOI:
- 10.4238/gmr16039809
IGF2BP2 gene polymorphism in the pathogenesis of vitiligo
Authors: Kursat Kargun, Betul Demir, Demet Cicek, Ozge Sevil Karstarli
Vitiligo is a disorder of pigmentation presenting with loss of melanocytes in the epidermis and hair follicles. The gene for insulin-like growth factor binding protein 2 (IGF2BP2) is located on the third chromosome and it plays role in growth, development, cellular differentiation, and metabolism. In the present study, we aime.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039808
- DOI:
- 10.4238/gmr16039808
Assessment of the rs4340 ACE gene polymorphism in acute coronary syndrome in a Western Mexican population
Authors: A. Valdez-Haro, Y. Valle, E. Valdes-Alvarado, F. Casillas-Mu?±oz, J.F. Mu?±oz-Valle, G.L. Reynoso-Villalpando, H.E. Flores-Salinas and J.R. Padilla-Guti?©rrez
Acute coronary syndrome (ACS) is considered one of the main causes of death worldwide. Contradictory findings concerning the impact of the angiotensin-converting enzyme (ACE) gene on cardiovascular diseases have been reported. Previous conclusions point out that the variability in results depends on ethnicity and genetic polym.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039779
- DOI:
- 10.4238/gmr16039779