Polymorphism
Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle
Authors: A.B. Grisolia1,2, G.T. D�Angelo1, L.R. Porto Neto1, F. Siqueira3 andJ.F. Garcia1
The myostatin gene, also known as GDF8 (growth differentiation factor 8), is located on bovine chromosome 2 (BTA2); it has three exons and two introns. Myostatin is specifically expressed during embryonic development and in adult skeletal muscle, functioning as a negative regulatory protein. Several cattle breeds (Piedmontese, Belgian Blue .. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr548
- DOI:
- 10.4238/vol8-3gmr548
Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine �²-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes
Authors: F.M. Amaral, A.L. Miranda-Vilela, G.S. Lordelo, I.F. Ribeiro, M.B. Daldegan and C.K. Grisolia
High plasma homocysteine (Hcy) âÂ?Â?âÂ?Â?levels may be responsible for vaso-occlusive episodes and may have acquired and/or genetic causes. This cross-sectional study aimed to investigate the role of methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C) and cystathionine-β-synthase (CBS; T833C/844ins68, G919A) poly.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019374
- DOI:
- 10.4238/gmr16019374
Identification of ANAPC13 gene polymorphisms associated with body measurement traits in Bos taurus
Authors: B.J. Jiang X.L. Zhan C.Z. Fu H.B. Wang G. Cheng L.S. Zan
Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. There has been some indication that ANAPC13 influences adult height. We used PCR-SSCP and DNA sequencing technology to identify polymorphisms in the ANAPC13 gene. A polymorphism in intron 1 (A > G at.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.15.6
- DOI:
- 10.4238/2012.June.15.6
Single nucleotide polymorphisms from Theobroma cacao expressed sequence tags associated with witches� broom disease in cacao
Authors: L.S. Lima1, K.P. Gramacho1, N. Carels2, R. Novais1, F.A. Gaiotto2,U.V. Lopes1, A.S. Gesteira2, H.A. Zaidan1,2, J.C.M. Cascardo2,J.L. Pires1 and F. Micheli2,3
In order to increase the efficiency of cacao tree resistance to witches’ broom disease, which is caused by Moniliophthora perniciosa (Tricholomataceae), we looked for molecular markers that could help in the selection of resistant cacao genotypes. Among the different markers useful for developing marker-assisted selection, single nucleotide polymorp.. Read More»
- Genet. Mol. Res. 8(3):
- vol8-3gmr603
- DOI:
- 10.4238/vol8-3gmr603
Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population
Authors: G. Shi, M.F. Zhang, P.Y. Liao, T.T. Wang, S.J. Li, Y.M. Fan, K.J. Zhu
Previously, we determined that the CARD11 rs4722404 single nucleotide polymorphism (SNP) increases risk of early-onset psoriasis vulgaris (PsV). Moreover, the CARD14 gene polymorphism c.C2458T (p.Arg820Trp) is associated with clinical features of this disease. CARMA1/CARD11, CARMA2/CARD14, and CARMA3/CARD10 are conserved acros.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019025
- DOI:
- 10.4238/gmr16019025
Association between the interleukin-1�² C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population
Authors: H.F. Wang, F.Q. He, C.J. Xu, D.M. Li, X.J. Sun, Y.T. Chi and W. Guo
The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019315
- DOI:
- 10.4238/gmr16019315
Genetic polymorphisms of EGF 5'-UTR and NAT2 857G/A associated with glioma in a case control study of Malaysian patients
Authors: K.A. Muthusamy L.H. Lian N. Vairavan K.H. Chua V. Wara
Studies of genetic mutations that have been used in predicting glioma prognosis have revealed a complex relationship between clinical and genetic factors. Epidermal growth factor (EGF) and the NAT2 gene play a central role in carcinogenesis. An adenine (A) to guanine (G) single nucleotide polymorphism at position 61 in the 5'-untranslated region (5'-UTR) of .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.15.7
- DOI:
- 10.4238/2012.June.15.7
Arylamine N-acetyltransferase 2 genotypes in a Mexican population
Authors: L. Taja-Chayeb, J.A. Ag�ºndez, C. Miguez-Mu�±oz, A. Chavez-Blanco and A. Due�±as-Gonzalez
The acetylating activity of N-acetyltransferase 2 (NAT2) has critical implications for therapeutics and disease susceptibility. To date, several polymorphisms that alter the enzymatic activity and/or protein stability of NAT2 have been identified. We examined the distribution and frequency of NAT2 genotypes in the Mexican popu.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.27.7
- DOI:
- 10.4238/2012.April.27.7
IL-8 -251A/T polymorphism contributes to coronary artery disease susceptibility in a Chinese population
Authors: R.J. Zhang, X.D. Li, S.W. Zhang, X.H. Li and L. Wu
Interleukin-8 (IL-8) is a mediator of inflammation and plays an important role in regulating immune responses. To date, several studies have tested the association between IL-8 gene polymorphisms and development of coronary artery disease (CAD), but their results have proved to be inconsistent. We conducted an investigation to.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018224
- DOI:
- 10.4238/gmr16018224
Polymorphism in the third intron of the interferon-�³ gene is associated with susceptibility to multiple sclerosis
Authors: X.L. Wang, F.R. Meng, X. Wang, S.H. Wang and L. Guo
The present study aims to examine the relationship between polymorphisms in the third intron of the IFN-γ gene and their influence on susceptibility to multiple sclerosis. A population-based case-control study was used for this purpose. Multiple sclerosis patients and healthy controls were interviewed. Genetic polymorphi.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16017538
- DOI:
- 10.4238/gmr16017538