Polymorphism
Lack of association between the cyclooxygenase 2 -765G>C polymorphism and prostate cancer risk: a meta-analysis
Authors: Y.-Q. Feng, Y.U. Li, W.-D. Xiao, G.-X. Wang and Y.O. Li
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis. A systematic literature search was performed using the PubMed, Embase, Cochrane Library, and Google Scholar databases by using the terms “cyclooxygenase-2/COX-2/PTGs2”.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.1
- DOI:
- 10.4238/2015.October.28.1
Meta-analysis demonstrates lack of association of the hOGG1 Ser326Cys polymorphism with bladder cancer risk
Authors: D.Y. Zhong H.Y. Chu M.L. Wang L. Ma D.N. Shi Z.D. Zhang
The functional polymorphism Ser326Cys (rs1052133) in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in bladder cancer risk. However, reports of this association between the Ser326Cys polymorphism and bladder cancer risk are conflicting. In order to help clarify this relationship, we made a meta-analysis of seven case-control studi.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.4
- DOI:
- 10.4238/2012.September.26.4
Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis
Authors: F. Zhang Y. Yang D. Hu H. Lei Y. Wang
Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls. The .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.26.7
- DOI:
- 10.4238/2012.September.26.7
Implicating the H63D polymorphism in the HFE gene in increased incidence of solid cancers: a meta-analysis
Authors: L.L. Shen, D.Y. Gu, T.T. Zhao, C.J. Tang, Y. Xu and J.F. Chen
A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors. However, the clinical outcomes were inconsistent. Therefore, this meta-analysis was conducted.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.36
- DOI:
- 10.4238/2015.October.28.36
The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population
Authors: H. Wang Y. Zhao J. Ma G. Zhang Y. Mu G. Qi Z. Fang L. Wang Q. Fan Z. Ma
Although lung cancer (LC) is a highly environmentally associated disease, genetic factors are also thought to play a role in this disease. In recent years, genome-wide association studies have identified various susceptible genetic regions for LC. Herein, we used high-resolution melting analysis to genotype 2 significant single nucleotide polymorphisms pr.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.22.5
- DOI:
- 10.4238/2013.January.22.5
Genetic diversity in the germplasm of tropical maize landraces determined using molecular markers
Authors: D. Molin C.J. Coelho D.S. M�¡ximo F.S. Ferreira J.R. Gardingo R.R. Matiello
Maize landraces derived from tropical germplasm represent an important source of genetic variability, which is currently poorly understood and under-exploited by Brazilian crop breeding programs. The aims of our study were to a) estimate the genetic diversity across 48 varieties of maize landraces cultivated at different locations in the States of Rio Grande.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.22.8
- DOI:
- 10.4238/2013.January.22.8
Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran
Authors: G. Bahari M. Hashemi M. Taheri M. Naderi A. Moazeni-Roodi H.R. Kouhpayeh E. Eskandari-Nasab
Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.24.8
- DOI:
- 10.4238/2013.January.24.8
Association between angiotensin-converting enzyme insertion/deletion polymorphisms and the risk of heart disease: an updated meta-analysis
Authors: F.J. You and D.M. Shen
Insertion/deletion (I/D) polymorphisms of the gene encoding angiotensin converting enzyme (ACE) are a controversial risk factor for heart diseases (HDs). ACE I/D polymorphism has been reported to be associated with various cardiovascular diseases. However, some studies have presented conflicting results. In this study, we aim to explore the association be.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017194
- DOI:
- 10.4238/gmr.15017194
Association of T1740C polymorphism of L-FABP with meat quality traits in Junmu No. 1 white swine
Authors: Y.H. Zhang L.S. Dai T.H. Ma S.Z. Wang J. Guo F.J. Li S.M. Zhang B.X. Sun D.F. Liu Y. Gao J.B. Zhang
This study was designed to investigate a single nucleotide polymorphism in intron 1 of the liver fatty acid-binding protein (L-FABP) gene in 156 Junmu No. 1 white swine using PCR-single-strand conformational polymorphism. The association between the polymorphism and meat quality traits was also studied. The cloning and sequencing results indicated that th.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.January.30.9
- DOI:
- 10.4238/2013.January.30.9
Relationship between CYP17 gene polymorphisms and risk of prostate cancer
Authors: J. Song, Z.-H. Tao, X.-Y. Liu, S. Gong and L. Gan
Cytochrome P450 17a-hydroxylase (CYP17) plays a critical role in androgen biosynthesis. Polymorphisms of the CYP17 promoter have been proposed as risk factors for prostate cancer; however, some studies have produced inconclusive or controversial results. We investigated the relationship between polymorphisms of the CYP17 gene and the risk of prostate canc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017866
- DOI:
- 10.4238/gmr.15017866