Polymorphism
Correlation between the development of calcium oxalate stones and polymorphisms in the fibronectin gene in the Uighur population of the Xinjiang region of China
Authors: M. Murat, A. Aekeper, L.Y. Yuan, T. Alim, G.J. Du, A. Abdusamat,G.W. Wu and Y. Aniwer
Here, we have investigated the correlation between calcium oxalate stone formation and Fn gene polymorphisms in urinary calculi patients among the Uighur population (Xinjiang region). In this case control study, genomic DNA extracted from the peripheral blood of 129 patients with calcium oxalate stones (patient group) and 94 normal people (control group) .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.35
- DOI:
- 10.4238/2015.October.28.35
Association analysis of rs2275913G>A and rs763780T>C interleukin 17 polymorphisms in Chinese women with cervical cancer
Authors: L.X. Sun, X.B. Wang and X.J. Huang
We conducted a case-control study with a relatively large sample size, and investigated the association between rs2275913G>A and rs763780T>C and the risk of cervical cancer. Three hundred and six newly diagnosed patients with histologically confirmed cervical cancer and 354 cancer-free control subjects were recruited from the Forestry General Hospit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.22
- DOI:
- 10.4238/2015.October.28.22
rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients
Authors: J.M. RodrÃ?Âguez-PÃ?©rez1*, G. Vargas-AlarcÃ?³n1*, R. Posadas-SÃ?¡nchez2,T.X. Zagal-JimÃ?©nez1, R. OrtÃ?Âz-AlarcÃ?³n1, B. Valente-Acosta1, C. Tovilla-ZÃ?¡rate3, C. Nostroza-HernÃ?¡ndez1, O. PÃ?©rez-MÃ?©ndez1 and N. PÃ?©rez-HernÃ?¡ndez1,4
Several studies have demonstrated that matrix metalloproteinases (MMPs) play a major role in atherosclerotic plaque disruption and lead to myocardial infarction (MI). We investigated the association between the MMP1 -1607 1G/2G (rs1799750), MMP3 -1612 5A/6A (rs3025058), and MMP9 -1562 C/T (rs3918242) polymorphisms and the risk of developing MI in a Mexica.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017776
- DOI:
- 10.4238/gmr.15017776
Meta-analysis demonstrates association between TLR polymorphisms and rheumatoid arthritis
Authors: Y.H. Lee S.-C. Bae G.G. Song
We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis .. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.7.2
- DOI:
- 10.4238/2013.February.7.2
VEGF, eNOS, and ABCB1 genetic polymorphisms may increase the risk of osteonecrosis of the femoral head
Authors: Z.C. Zhou, S.Z. Gu, J. Wu and Q.W. Liang
We investigated the associations between vascular endothelial growth factors (VEGF), endothelial nitric oxide synthase (eNOS), and ATP-binding cassette subfamily B member 1 transporter (ABCB1) polymorphisms and the risk of osteonecrosis of the femoral head (ONFH). Published studies were reviewed and analyzed based on predefined selection criteria. The str.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.28.31
- DOI:
- 10.4238/2015.October.28.31
Polymorphisms of the bovine growth differentiation factor 9 gene associated with superovulation performance in Chinese Holstein cows
Authors: K.Q. Tang W.C. Yang S.J. Li L.-G. Yang
Growth differentiation factor 9 (GDF9) belongs to the transforming growth factor Ã?² superfamily and plays a critical role in ovarian follicular development and ovulation rate. We examined the bovine GDF9 gene polymorphism and analyzed its association with superovulation performance. Based on the sequence of the bovine GDF9 gene, six pairs of primers were d.. Read More»
- Genet. Mol. Res. 12(1):
- 2013.February.8.3
- DOI:
- 10.4238/2013.February.8.3
The role of smoking status and collagen IX polymorphisms in the susceptibility to cervical spondylotic myelopathy
Authors: Z.C. Wang, J.G. Shi, X.S. Chen, G.H. Xu, L.J. Li and L.S. Jia
We investigated a possible association of collagen IX tryptophan (Trp) alleles (Trp2 and Trp3) and smoking with cervical spondylotic myelopathy (CSM) in 172 Chinese patients and 176 age- and gender-matched controls. The smoking status was evaluated by smoking index (SI). The CSM cases had a significantly higher prevalence of T.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.9.2
- DOI:
- 10.4238/2012.May.9.2
Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors
Authors: Z.H. Chen, J.F. Xian and L.P. Luo
Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals’ susceptibility to cancers. We aimed to investigate the asso.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018877
- DOI:
- 10.4238/gmr16018877
Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population
Authors: J.D. Sun, H. Yuan, H.Q. Hu and H.M. Yu
We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People’s Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N =.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016954
- DOI:
- 10.4238/gmr.15016954
Genotypic and allelic frequencies of gene polymorphisms associated with meat tenderness in Nellore beef cattle
Authors: M.E. Carvalho, J.P. Eler, M.N. Bonin, F.M. Rezende, F.H. Biase, F.V. Meirelles, L.C.A. Regitano, L.L. Coutinho, J.C.C. Balieiro and J.B.S. Ferraz
The objectives of this study were to characterize the allelic and genotypic frequencies of polymorphisms in the µ-calpain and calpastatin genes, and to assess their association with meat tenderness and animal growth in Nellore cattle. We evaluated 605 Nellore animals at 24 months of age, on average, at slaughter. The pol.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16018957
- DOI:
- 10.4238/gmr16018957